iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000007980.2	ENSLACT00000025110.1	ENSLACP00000023325.1
ENSLACG00000007980.2	ENSLACT00000009107.1	ENSLACP00000009038.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-120	402.0	2122	2580

Active Site

Position(s)	Description	Evidence
2549	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2122 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRKELGIWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglftapfpqdsde 2207
           6799****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2208 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliydsrgdrdfhytesqseasteeghdslsvgsldedsk 2294
           *************************************99999999999999999999999999999999999999988888777777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena........es..........................dieelgld 138
                          ++  l++ed+e v+ +++++lkeike+a        ++                          +ie+lgl+
   Q: 2295 sefildppkpkppawFHGILTWEDFELVNLHRARFLKEIKELAvkrrqilsNKalsedekntklqdlmlknpsgsgpplSIEDLGLN 2381
           7777666666666655558***********************97666665511666677788899999999999************* PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe..ee 223
           ++f++s+++ g ++++ Lkp+Ge++ Vt++N+eeYv+l++++++++gi++q+ afr+Gfn+v+p+e+ls+F++ee+++++cG+  ++
   Q: 2382 FQFCPSSKVHGFAAVD-LKPNGEDEVVTIDNAEEYVELMFDFCMHTGIQKQMGAFRDGFNRVFPMEKLSSFSHEEVQMILCGNqsPS 2467
           *******999988888.******************************************************************6666 PP
   S: 224  idvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLk 309
           +++ed+++ t+ k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++yLk
   Q: 2468 WTAEDITNYTEPKLGYTRDSPGFMRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVHYLK 2554
           777777777777*************************************************************************** PP
   S: 310  LPeYsskeilkekLlyAieetkgFels 336
           LPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2555 LPEYSSEEIMRERLLAATME-KGFHLN 2580
           ********************.****86 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSDNVDRCFE TCPPRTFLPA LCKIFLDESA PDNVLEVTAR AITYYLDVSA ECTRRIVGVD 60
GAIKALCNRL VVVELNNRTS RDLAEQCVKV LELICTRESG AVFEAGGLNC VLTFIRDSGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGCGCGC CCCCGTGATG AATCCTCCTC TTTGCTGGAG CACTGTGGTT AGAGAGCGAC 60
GGCTCGACTG TCTCATTTCC TGCAGCCTCT GCGCTGCAGC ACAATGGACT CGGCGGTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	92.33	0.00e+00	4235.00
IUUC-Apl-003493	Anas platyrhynchos	92.47	0.00e+00	4260.00
IUUC-Aca-004521	Anolis carolinensis	94.69	0.00e+00	2678.00
IUUC-Ame-011258	Astyanax mexicanus	91.09	0.00e+00	2299.00
IUUC-Bta-012835	Bos taurus	92.25	0.00e+00	4247.00
IUUC-Cel-018153	Caenorhabditis elegans	50.74	6.00e-162	566.00
IUUC-Cja-019174	Callithrix jacchus	91.34	0.00e+00	4158.00
IUUC-Cfa-021115	Canis familiaris	92.21	0.00e+00	4199.00
IUUC-Cpo-022382	Cavia porcellus	88.30	0.00e+00	3999.00
IUUC-Csa-023230	Chlorocebus sabaeus	92.40	0.00e+00	4246.00
IUUC-Cho-024711	Choloepus hoffmanni	88.36	0.00e+00	1518.00
IUUC-Cin-025342	Ciona intestinalis	52.28	0.00e+00	1314.00
IUUC-Csv-026031	Ciona savignyi	50.97	0.00e+00	1334.00
IUUC-Dre-027435	Danio rerio	90.59	0.00e+00	2552.00
IUUC-Dno-029954	Dasypus novemcinctus	92.33	0.00e+00	4220.00
IUUC-Dor-030734	Dipodomys ordii	92.03	0.00e+00	1394.00
IUUC-Dme-031739	Drosophila melanogaster	58.70	0.00e+00	1555.00
IUUC-Ete-033192	Echinops telfairi	87.90	0.00e+00	1087.00
IUUC-Eca-033434	Equus caballus	91.61	0.00e+00	4204.00
IUUC-Eeu-035031	Erinaceus europaeus	79.92	0.00e+00	978.00
IUUC-Fca-035998	Felis catus	90.81	0.00e+00	4135.00
IUUC-Fal-037468	Ficedula albicollis	93.47	0.00e+00	2657.00
IUUC-Gmo-038495	Gadus morhua	90.79	0.00e+00	1297.00
IUUC-Gga-040736	Gallus gallus	94.99	0.00e+00	2664.00
IUUC-Gac-041777	Gasterosteus aculeatus	90.98	0.00e+00	2320.00
IUUC-Ggo-044677	Gorilla gorilla	87.98	0.00e+00	3966.00
IUUC-Hsa-045879	Homo sapiens	92.40	0.00e+00	4246.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	92.25	0.00e+00	4247.00
IUUC-Loc-051986	Lepisosteus oculatus	89.42	0.00e+00	4120.00
IUUC-Laf-054230	Loxodonta africana	91.73	0.00e+00	4171.00
IUUC-Mcc-054787	Macaca mulatta	92.40	0.00e+00	4246.00
IUUC-Meu-056502	Macropus eugenii	84.65	0.00e+00	1246.00
IUUC-Mga-059409	Meleagris gallopavo	85.71	0.00e+00	1942.00
IUUC-Mmr-061667	Microcebus murinus	91.81	0.00e+00	4209.00
IUUC-Mdo-061960	Monodelphis domestica	92.56	0.00e+00	4246.00
IUUC-Mmu-063941	Mus musculus	91.23	0.00e+00	4180.00
IUUC-Mpu-065939	Mustela putorius furo	92.44	0.00e+00	4248.00
IUUC-Mlu-068112	Myotis lucifugus	92.21	0.00e+00	4214.00
IUUC-Nle-069001	Nomascus leucogenys	92.36	0.00e+00	4245.00
IUUC-Opr-071222	Ochotona princeps	91.53	0.00e+00	1975.00
IUUC-Ont-072101	Oreochromis niloticus	86.16	0.00e+00	2552.00
IUUC-Oan-072814	Ornithorhynchus anatinus	92.71	0.00e+00	4244.00
IUUC-Ocu-074011	Oryctolagus cuniculus	92.36	0.00e+00	4248.00
IUUC-Ola-086412	Oryzias latipes	91.21	0.00e+00	2315.00
IUUC-Oar-089668	Ovis aries	92.25	0.00e+00	4241.00
IUUC-Ptr-090517	Pan troglodytes	91.87	0.00e+00	4194.00
IUUC-Pan-091849	Papio anubis	89.73	0.00e+00	4073.00
IUUC-Psi-093390	Pelodiscus sinensis	91.76	0.00e+00	2563.00
IUUC-Pma-094628	Petromyzon marinus	83.09	0.00e+00	1565.00
IUUC-Pfo-097075	Poecilia formosa	92.06	0.00e+00	2369.00
IUUC-Pab-098176	Pongo abelii	92.40	0.00e+00	4246.00
IUUC-Pca-101123	Procavia capensis	83.29	0.00e+00	2178.00
IUUC-Pva-103008	Pteropus vampyrus	84.07	0.00e+00	1643.00
IUUC-Rno-105885	Rattus norvegicus	91.86	0.00e+00	4226.00
IUUC-Sha-107048	Sarcophilus harrisii	91.79	0.00e+00	4209.00
IUUC-Sar-113071	Sorex araneus	91.06	0.00e+00	1175.00
IUUC-Ssc-115963	Sus scrofa	91.59	0.00e+00	4237.00
IUUC-Tgu-117167	Taeniopygia guttata	88.31	0.00e+00	2476.00
IUUC-Tru-118626	Takifugu rubripes	85.50	0.00e+00	2550.00
IUUC-Tsy-119504	Tarsius syrichta	91.29	0.00e+00	2171.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.38	0.00e+00	2342.00
IUUC-Tbe-127602	Tupaia belangeri	87.69	0.00e+00	944.00
IUUC-Ttr-128394	Tursiops truncatus	88.34	0.00e+00	2816.00
IUUC-Vpa-130280	Vicugna pacos	91.18	0.00e+00	4004.00
IUUC-Xtr-131787	Xenopus tropicalis	85.46	0.00e+00	2492.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence