iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089323

Ensembl Protein ID

ENSOARP00000018181.1

UniProt Accession

W5Q641; W5Q641_SHEEP

Genbank Protein ID

ENSOARP00000018181

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AMGL01027638

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000016927.1	ENSOART00000018438.1	ENSOARP00000018181.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	445.00	IUUC-Dme-031700
E3 activity/RING/RING	96.81	0.00e+00	632.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.29	1.00e-167	586.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ovis aries

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTGKSPLPFL CSWRGILLTC LPASGTRKRK EMSRQTATAL PTGTSKCAPS QRVPALTGTT 60
ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCGGGA AGTCTCCCTT ACCTTTTCTG TGCTCCTGGA GAGGCATCTT GCTCACTTGT 60
TTACCAGCAT CTGGGACAAG GAAGAGAAAA GGTACTGCTA TTAAGAGACT GTGTTGCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101111116

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	36.68	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	98.40	0.00e+00	646.00
IUUC-Atr-002857	Amborella trichopoda	36.06	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	99.65	7.00e-170	589.00
IUUC-Aca-005014	Anolis carolinensis	99.65	1.00e-170	592.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	32.87	4.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	88.24	1.00e-169	588.00
IUUC-Bta-012887	Bos taurus	99.36	0.00e+00	650.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	4.00e-45	174.00
IUUC-Bol-016263	Brassica oleracea	33.45	7.00e-43	167.00
IUUC-Bra-016910	Brassica rapa	36.82	2.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	66.79	1.00e-114	406.00
IUUC-Cja-019796	Callithrix jacchus	96.81	0.00e+00	630.00
IUUC-Cfa-020642	Canis familiaris	99.65	7.00e-172	595.00
IUUC-Cpo-022348	Cavia porcellus	99.65	2.00e-169	587.00
IUUC-Csa-023974	Chlorocebus sabaeus	96.81	0.00e+00	632.00
IUUC-Cin-025674	Ciona intestinalis	78.01	1.00e-134	472.00
IUUC-Csv-026233	Ciona savignyi	84.25	4.00e-132	463.00
IUUC-Dre-028041	Danio rerio	87.62	9.00e-169	585.00
IUUC-Dno-029764	Dasypus novemcinctus	99.65	2.00e-170	591.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	1.00e-119	422.00
IUUC-Ete-032423	Echinops telfairi	99.25	1.00e-159	555.00
IUUC-Eca-033536	Equus caballus	99.65	7.00e-170	589.00
IUUC-Eeu-035314	Erinaceus europaeus	96.06	5.00e-160	556.00
IUUC-Fca-035362	Felis catus	98.40	0.00e+00	642.00
IUUC-Fal-037487	Ficedula albicollis	94.25	5.00e-177	612.00
IUUC-Gga-040269	Gallus gallus	99.65	7.00e-170	589.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	1.00e-166	578.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	159.00
IUUC-Ggo-045444	Gorilla gorilla	96.81	0.00e+00	632.00
IUUC-Hsa-046357	Homo sapiens	96.81	0.00e+00	632.00
IUUC-Hvu-047574	Hordeum vulgare	36.33	2.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.65	2.00e-169	587.00
IUUC-Lch-049504	Latimeria chalumnae	99.29	2.00e-169	587.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	167.00
IUUC-Loc-052191	Lepisosteus oculatus	97.92	1.00e-170	592.00
IUUC-Laf-053668	Loxodonta africana	99.65	7.00e-170	589.00
IUUC-Mcc-054640	Macaca mulatta	96.81	0.00e+00	632.00
IUUC-Mtr-058747	Medicago truncatula	34.81	4.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	97.26	9.00e-171	592.00
IUUC-Mmr-060794	Microcebus murinus	99.65	2.00e-169	587.00
IUUC-Mmu-064129	Mus musculus	99.29	5.00e-169	586.00
IUUC-Mac-065670	Musa acuminata	36.07	3.00e-42	165.00
IUUC-Mpu-066488	Mustela putorius furo	98.72	0.00e+00	647.00
IUUC-Mlu-067207	Myotis lucifugus	99.65	7.00e-171	592.00
IUUC-Nle-069706	Nomascus leucogenys	96.49	0.00e+00	630.00
IUUC-Ont-071849	Oreochromis niloticus	97.17	2.00e-167	580.00
IUUC-Ocu-074876	Oryctolagus cuniculus	97.44	0.00e+00	635.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.71	3.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	39.58	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	7.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.16	1.00e-166	578.00
IUUC-Oga-088399	Otolemur garnettii	99.65	2.00e-169	587.00
IUUC-Ptr-090692	Pan troglodytes	99.65	3.00e-170	590.00
IUUC-Pan-092012	Papio anubis	96.81	0.00e+00	632.00
IUUC-Psi-093687	Pelodiscus sinensis	95.56	1.00e-180	625.00
IUUC-Pma-094387	Petromyzon marinus	93.66	2.00e-160	557.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	7.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	97.16	1.00e-166	578.00
IUUC-Pab-097555	Pongo abelii	96.81	0.00e+00	632.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	172.00
IUUC-Ppe-101760	Prunus persica	36.10	5.00e-44	171.00
IUUC-Rno-104866	Rattus norvegicus	99.29	5.00e-169	586.00
IUUC-Sha-106547	Sarcophilus harrisii	97.12	0.00e+00	633.00
IUUC-Smo-109412	Selaginella moellendorffii	32.64	5.00e-39	154.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	3.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	36.76	2.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	99.65	7.00e-170	589.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	5.00e-163	566.00
IUUC-Tca-121228	Theobroma cacao	33.44	3.00e-41	162.00
IUUC-Tae-123647	Triticum aestivum	36.68	2.00e-44	172.00
IUUC-Tur-126259	Triticum urartu	34.88	8.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	7.00e-143	499.00
IUUC-Vvi-131233	Vitis vinifera	34.60	9.00e-43	167.00
IUUC-Xtr-132553	Xenopus tropicalis	98.94	3.00e-169	587.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	1.00e-166	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence