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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046403
Ensembl Protein ID ENSP00000328671.2
UniProt Accession P57081; A8KA58; B2RCA3; B4DNQ7; D3DSK3; Q9BVM5; Q9HCR3; WDR4_HUMAN
Genbank Protein ID CAB93144.1; CAB93145.1; BAG51684.1; BAF85612.1; BAG60319.1; BAG37500.1; BAB13726.1; EAX09528.1; EAX09529.1; AAH01074.1; AAH06341.1
Protein Name tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4
Genbank Nucleotide ID AJ243912; AJ243913; AK056343; AK292923; AK298015; AK315008; AB039887; AP001629; CH471079; BC001074; BC006341
Gene Name WDR4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160193.11 ENST00000330317.6 ENSP00000328671.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-07 31.9 186 225
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+ ++   +  +ll+s+s+Dgt+++W++r+g++l+
   Q: 186  GHTEFVSRISVvpTQpGLLLSSSGDGTLRLWEYRSGRQLH 225
           67777777776853369*******************9986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
 Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Protein Sequence
(Fasta)
MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN KGEDAPLDQG 60
SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046403|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGTCACCGA CCGGTGCGGA CAGGAAGAGG CTCTGGGCTG GCACATGTGT ATGGCGGTGA 60
GGCGGGCGGG TACATGGCGG GCTCTGTGGG ACTGGCGTTG TGCGGGCAGA CGTTGGTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046403|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0006400--P:tRNA modification
KEGG hsa:10785
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000556 Aegilops tauschii 33.74 5.00e-11 62.40
IUUC-Apl-003975 Anas platyrhynchos 60.18 4.00e-121 428.00
IUUC-Aca-005170 Anolis carolinensis 53.93 1.00e-103 370.00
IUUC-Aly-005769 Arabidopsis lyrata 30.45 3.00e-24 106.00
IUUC-Ath-006733 Arabidopsis thaliana 35.38 2.00e-23 103.00
IUUC-Acl-008151 Aspergillus clavatus 35.62 4.00e-15 76.30
IUUC-Afl-008518 Aspergillus flavus 34.25 3.00e-17 82.80
IUUC-Afu-009102 Aspergillus fumigatus 35.06 5.00e-13 69.30
IUUC-Ani-009442 Aspergillus nidulans 25.66 2.00e-15 77.00
IUUC-Aor-010133 Aspergillus oryzae 27.70 2.00e-20 93.60
IUUC-Ate-010465 Aspergillus terreus 37.29 3.00e-14 73.60
IUUC-Ame-010613 Astyanax mexicanus 45.63 3.00e-87 315.00
IUUC-Bgr-012067 Blumeria graminis 33.56 2.00e-18 87.40
IUUC-Bta-012788 Bos taurus 77.24 1.00e-180 625.00
IUUC-Bdi-014458 Brachypodium distachyon 37.44 2.00e-19 90.50
IUUC-Bol-015373 Brassica oleracea 36.41 2.00e-23 105.00
IUUC-Bra-016644 Brassica rapa 38.12 2.00e-23 105.00
IUUC-Cpo-021963 Cavia porcellus 78.84 2.00e-169 588.00
IUUC-Csa-024148 Chlorocebus sabaeus 96.36 0.00e+00 688.00
IUUC-Cne-026834 Cryptococcus neoformans 35.10 3.00e-19 90.10
IUUC-Dre-028427 Danio rerio 47.65 7.00e-90 324.00
IUUC-Dno-028881 Dasypus novemcinctus 69.14 3.00e-156 544.00
IUUC-Dor-030522 Dipodomys ordii 75.06 3.00e-165 574.00
IUUC-Dme-032136 Drosophila melanogaster 33.01 4.00e-25 109.00
IUUC-Fca-035833 Felis catus 73.21 2.00e-165 575.00
IUUC-Fal-037497 Ficedula albicollis 57.29 6.00e-119 420.00
IUUC-Gga-040547 Gallus gallus 58.54 1.00e-123 436.00
IUUC-Gac-041761 Gasterosteus aculeatus 44.68 8.00e-83 300.00
IUUC-Gma-043941 Glycine max 35.94 4.00e-26 112.00
IUUC-Ggo-045340 Gorilla gorilla 97.82 0.00e+00 756.00
IUUC-Hvu-047643 Hordeum vulgare 39.89 2.00e-20 93.60
IUUC-Itr-048103 Ictidomys tridecemlineatus 80.15 4.00e-178 617.00
IUUC-Kpa-049283 Komagataella pastoris 33.96 2.00e-18 86.70
IUUC-Lch-050682 Latimeria chalumnae 48.89 2.00e-106 379.00
IUUC-Lpe-050712 Leersia perrieri 36.32 3.00e-23 102.00
IUUC-Loc-052599 Lepisosteus oculatus 51.84 4.00e-115 408.00
IUUC-Laf-054390 Loxodonta africana 77.97 6.00e-177 613.00
IUUC-Mcc-054747 Macaca mulatta 96.12 0.00e+00 719.00
IUUC-Mtr-058600 Medicago truncatula 39.33 2.00e-24 107.00
IUUC-Mla-059129 Melampsora laricipopulina 26.15 7.00e-13 67.80
IUUC-Mga-059876 Meleagris gallopavo 56.96 2.00e-122 432.00
IUUC-Mvi-060359 Microbotryum violaceum 29.35 5.00e-13 69.70
IUUC-Mmr-061518 Microcebus murinus 82.32 0.00e+00 648.00
IUUC-Mac-065625 Musa acuminata 34.04 2.00e-20 94.00
IUUC-Nfi-068402 Neosartorya fischeri 27.37 2.00e-14 73.60
IUUC-Nle-069914 Nomascus leucogenys 95.15 0.00e+00 707.00
IUUC-Ont-071555 Oreochromis niloticus 41.78 9.00e-78 283.00
IUUC-Oan-072951 Ornithorhynchus anatinus 67.35 2.00e-151 528.00
IUUC-Ocu-074679 Oryctolagus cuniculus 81.18 1.00e-169 589.00
IUUC-Oba-075355 Oryza barthii 27.86 4.00e-11 62.80
IUUC-Obr-076769 Oryza brachyantha 32.44 1.00e-24 107.00
IUUC-Ogl-077168 Oryza glaberrima 33.71 4.00e-25 108.00
IUUC-Ogu-078275 Oryza glumaepatula 27.20 2.00e-11 63.90
IUUC-Oin-079207 Oryza indica 33.71 4.00e-25 108.00
IUUC-Oni-082437 Oryza nivara 28.69 1.00e-11 65.10
IUUC-Opu-084031 Oryza punctata 33.82 3.00e-23 103.00
IUUC-Oru-084380 Oryza rufipogon 28.05 5.00e-11 62.80
IUUC-Osa-085327 Oryza sativa 34.26 6.00e-25 108.00
IUUC-Ola-086716 Oryzias latipes 44.21 8.00e-79 287.00
IUUC-Olu-087708 Ostreococcus lucimarinus 29.10 1.00e-13 70.90
IUUC-Oar-090239 Ovis aries 80.59 3.00e-172 597.00
IUUC-Ptr-090851 Pan troglodytes 98.30 0.00e+00 759.00
IUUC-Pan-092558 Papio anubis 96.14 0.00e+00 688.00
IUUC-Psi-093792 Pelodiscus sinensis 59.51 1.00e-129 456.00
IUUC-Ppa-095757 Physcomitrella patens 40.59 3.00e-21 96.30
IUUC-Pfo-096465 Poecilia formosa 41.86 1.00e-84 306.00
IUUC-Pab-097722 Pongo abelii 96.60 0.00e+00 740.00
IUUC-Pop-098979 Populus trichocarpa 35.68 3.00e-20 93.20
IUUC-Pca-100753 Procavia capensis 74.05 4.00e-116 411.00
IUUC-Ppe-101515 Prunus persica 35.52 8.00e-20 91.70
IUUC-Sja-107780 Schizosaccharomyces japonicus 26.77 6.00e-15 75.50
IUUC-Spo-108251 Schizosaccharomyces pombe 30.04 1.00e-13 71.20
IUUC-Smo-108938 Selaginella moellendorffii 37.82 1.00e-24 107.00
IUUC-Sit-110020 Setaria italica 36.08 8.00e-23 101.00
IUUC-Sly-111543 Solanum lycopersicum 34.24 2.00e-22 100.00
IUUC-Stu-111925 Solanum tuberosum 32.99 1.00e-22 100.00
IUUC-Sbi-114061 Sorghum bicolor 39.23 9.00e-23 101.00
IUUC-Tgu-117321 Taeniopygia guttata 58.72 2.00e-112 399.00
IUUC-Tru-118454 Takifugu rubripes 44.50 6.00e-81 294.00
IUUC-Tni-119894 Tetraodon nigroviridis 44.82 7.00e-78 284.00
IUUC-Tca-121746 Theobroma cacao 35.15 9.00e-22 98.20
IUUC-Tae-124114 Triticum aestivum 39.33 8.00e-20 91.70
IUUC-Tur-126254 Triticum urartu 33.53 1.00e-12 67.80
IUUC-Tbe-127683 Tupaia belangeri 52.08 1.00e-58 220.00
IUUC-Ttr-129056 Tursiops truncatus 73.12 6.00e-161 560.00
IUUC-Vvi-131428 Vitis vinifera 36.27 1.00e-21 97.80
IUUC-Xma-133605 Xiphophorus maculatus 42.16 2.00e-85 309.00
Created Date 25-Jun-2017

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