iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010541.4	ENSGALT00000017157.4	ENSGALP00000017138.4
ENSGALG00000010541.4	ENSGALT00000046963.1	ENSGALP00000053027.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.10e-34	117.4	4577	4733

Active Site

Position(s)	Description	Evidence
4666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp....egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyen 78
           Rl++e+ +l+++ p    +++++++++e  l+ ++vli+Gp+dtpY++g+F+++++fp+dYP +PP v+++t+     +f+Pn+y++
   Q: 4577 RLAQEAVTLSTSLPlsssSSVFVRCDEE-RLDIMKVLITGPADTPYANGCFEFDVYFPQDYPNSPPLVNLETTgghsvRFNPNLYND 4662
           8999999999998877768899999999.6********************************************************* PP
   S: 79   GkvClsilk.....eeekWsp.alsvesvllsiqsll..aepnpesplneeaa...ellkknreeykkkvre 139
           GkvClsil+     +eekW+p ++s+ +vl+s+qsl+  aep++++p +e+++   + ++++re y+ ++r+
   Q: 4663 GKVCLSILNtwhgrPEEKWNPqTSSFLQVLVSVQSLIlvAEPYFNEPGYERSRgtpSGTQSSRE-YDGNIRQ 4733
           ********7788889******8899***********999***********99866555666655.9998875 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAAAAASCSA AAPAGPGPGP ASAGPGSCEW LLLRDGCLRC DADGLCSLCY HPALNAILAV 60
TARGAIKVID GTSGATLQAS ALNAKPGGRV KCQYISAVDK VIFVDDYAVG CRKDLNGILL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGCCTC CTGCTCCGCG GCGGCTCCCG CTGGGCCCGG ACCGGGGCCG 60
GCGTCGGCCG GGCCGGGCTC CTGCGAGTGG CTGCTGCTGC GGGACGGCTG CCTGCGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001370--BIR_rpt
IPR022103--BIRC6
IPR008979--Galactose-bd-like
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50143--BIR_REPEAT_2
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00653--BIR
PF12356--BIRC6
PF00179--UQ_con

SMART

SM00238--BIR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0016020--C:membrane
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0000922--C:spindle pole
GO:0005802--C:trans-Golgi network
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0032465--P:regulation of cytokinesis
GO:0009966--P:regulation of signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001583	Ailuropoda melanoleuca	92.24	0.00e+00	8294.00
IUUC-Apl-004144	Anas platyrhynchos	98.49	0.00e+00	5981.00
IUUC-Aca-005257	Anolis carolinensis	93.01	0.00e+00	8344.00
IUUC-Ame-011337	Astyanax mexicanus	78.96	0.00e+00	6769.00
IUUC-Bta-012501	Bos taurus	91.32	0.00e+00	8129.00
IUUC-Bdi-014931	Brachypodium distachyon	38.87	4.00e-47	182.00
IUUC-Bol-015976	Brassica oleracea	39.50	2.00e-45	176.00
IUUC-Bra-017967	Brassica rapa	39.50	9.00e-46	177.00
IUUC-Cel-018661	Caenorhabditis elegans	35.68	9.00e-79	288.00
IUUC-Cja-018746	Callithrix jacchus	92.12	0.00e+00	8231.00
IUUC-Cfa-020170	Canis familiaris	92.10	0.00e+00	8161.00
IUUC-Cpo-022138	Cavia porcellus	92.36	0.00e+00	5580.00
IUUC-Cre-022768	Chlamydomonas reinhardtii	44.13	2.00e-44	171.00
IUUC-Csa-023927	Chlorocebus sabaeus	92.76	0.00e+00	8287.00
IUUC-Cho-024890	Choloepus hoffmanni	90.22	0.00e+00	1879.00
IUUC-Cne-026995	Cryptococcus neoformans	42.62	2.00e-37	151.00
IUUC-Dre-027941	Danio rerio	81.13	0.00e+00	7169.00
IUUC-Dno-028913	Dasypus novemcinctus	90.55	0.00e+00	8118.00
IUUC-Dor-030715	Dipodomys ordii	89.86	0.00e+00	1861.00
IUUC-Dse-031232	Dothistroma septosporum	44.51	4.00e-38	153.00
IUUC-Dme-031592	Drosophila melanogaster	53.03	0.00e+00	679.00
IUUC-Ete-032587	Echinops telfairi	73.99	0.00e+00	1988.00
IUUC-Eca-033819	Equus caballus	92.12	0.00e+00	8206.00
IUUC-Eeu-034863	Erinaceus europaeus	82.65	0.00e+00	2445.00
IUUC-Fca-035505	Felis catus	89.72	0.00e+00	7945.00
IUUC-Fal-037318	Ficedula albicollis	97.81	0.00e+00	8695.00
IUUC-Gmo-039521	Gadus morhua	83.67	0.00e+00	1722.00
IUUC-Ggr-040040	Gaeumannomyces graminis	47.06	1.00e-33	138.00
IUUC-Gac-042251	Gasterosteus aculeatus	85.99	0.00e+00	1825.00
IUUC-Ggo-045562	Gorilla gorilla	92.49	0.00e+00	1535.00
IUUC-Hsa-046339	Homo sapiens	92.18	0.00e+00	8164.00
IUUC-Hvu-047441	Hordeum vulgare	47.25	7.00e-48	184.00
IUUC-Itr-048099	Ictidomys tridecemlineatus	92.06	0.00e+00	2597.00
IUUC-Lch-050164	Latimeria chalumnae	86.53	0.00e+00	7596.00
IUUC-Lpe-051294	Leersia perrieri	39.85	6.00e-47	181.00
IUUC-Loc-052800	Lepisosteus oculatus	86.77	0.00e+00	7675.00
IUUC-Laf-054034	Loxodonta africana	91.29	0.00e+00	8190.00
IUUC-Mcc-055267	Macaca mulatta	92.36	0.00e+00	8242.00
IUUC-Meu-056461	Macropus eugenii	91.81	0.00e+00	1224.00
IUUC-Mpo-057396	Magnaporthe poae	48.39	3.00e-34	140.00
IUUC-Mtr-057797	Medicago truncatula	39.92	5.00e-48	184.00
IUUC-Mla-059114	Melampsora laricipopulina	28.49	3.00e-41	163.00
IUUC-Mga-059594	Meleagris gallopavo	98.59	0.00e+00	8279.00
IUUC-Mmr-061179	Microcebus murinus	92.38	0.00e+00	8233.00
IUUC-Mdo-062990	Monodelphis domestica	93.56	0.00e+00	8222.00
IUUC-Mmu-063825	Mus musculus	90.21	0.00e+00	8037.00
IUUC-Mac-064881	Musa acuminata	43.41	6.00e-42	164.00
IUUC-Mpu-065908	Mustela putorius furo	92.75	0.00e+00	5341.00
IUUC-Mlu-067106	Myotis lucifugus	90.76	0.00e+00	8138.00
IUUC-Nle-069347	Nomascus leucogenys	92.28	0.00e+00	8218.00
IUUC-Opr-070799	Ochotona princeps	82.83	0.00e+00	2413.00
IUUC-Ont-072046	Oreochromis niloticus	79.81	0.00e+00	6817.00
IUUC-Oan-073415	Ornithorhynchus anatinus	93.80	0.00e+00	3434.00
IUUC-Ocu-074556	Oryctolagus cuniculus	92.35	0.00e+00	8198.00
IUUC-Oba-075870	Oryza barthii	39.31	9.00e-48	184.00
IUUC-Obr-076823	Oryza brachyantha	48.90	3.00e-46	178.00
IUUC-Ogl-077412	Oryza glaberrima	39.31	7.00e-48	184.00
IUUC-Ogu-077966	Oryza glumaepatula	39.31	8.00e-48	184.00
IUUC-Oin-080009	Oryza indica	39.46	2.00e-47	183.00
IUUC-Olo-080416	Oryza longistaminata	40.67	3.00e-40	160.00
IUUC-Oni-082326	Oryza nivara	39.46	2.00e-47	183.00
IUUC-Oru-085077	Oryza rufipogon	39.31	8.00e-48	184.00
IUUC-Osa-086014	Oryza sativa	39.31	1.00e-47	183.00
IUUC-Ola-087459	Oryzias latipes	83.93	0.00e+00	2940.00
IUUC-Oga-088251	Otolemur garnettii	89.89	0.00e+00	7827.00
IUUC-Oar-090367	Ovis aries	91.93	0.00e+00	8166.00
IUUC-Ptr-091512	Pan troglodytes	92.18	0.00e+00	8208.00
IUUC-Pan-092222	Papio anubis	91.67	0.00e+00	8172.00
IUUC-Pma-094574	Petromyzon marinus	61.87	0.00e+00	3013.00
IUUC-Ppa-095592	Physcomitrella patens	30.00	2.00e-56	213.00
IUUC-Pfo-097086	Poecilia formosa	78.80	0.00e+00	6900.00
IUUC-Pab-098390	Pongo abelii	90.69	0.00e+00	8000.00
IUUC-Pop-099284	Populus trichocarpa	37.75	3.00e-42	166.00
IUUC-Pca-101036	Procavia capensis	84.04	0.00e+00	3932.00
IUUC-Ppe-101722	Prunus persica	37.17	6.00e-44	172.00
IUUC-Pva-103053	Pteropus vampyrus	87.33	0.00e+00	3400.00
IUUC-Pte-104333	Pyrenophora teres	41.79	2.00e-44	174.00
IUUC-Pyt-104498	Pyrenophora triticirepentis	39.83	6.00e-45	175.00
IUUC-Rno-106049	Rattus norvegicus	90.38	0.00e+00	6573.00
IUUC-Sha-107483	Sarcophilus harrisii	90.47	0.00e+00	7780.00
IUUC-Smo-108915	Selaginella moellendorffii	42.59	2.00e-44	172.00
IUUC-Sly-110929	Solanum lycopersicum	38.37	4.00e-47	182.00
IUUC-Stu-112554	Solanum tuberosum	38.37	2.00e-46	180.00
IUUC-Sar-112965	Sorex araneus	81.45	0.00e+00	1709.00
IUUC-Ssc-115927	Sus scrofa	93.01	0.00e+00	5732.00
IUUC-Tgu-117132	Taeniopygia guttata	97.05	0.00e+00	8556.00
IUUC-Tru-118115	Takifugu rubripes	76.51	0.00e+00	6708.00
IUUC-Tsy-118899	Tarsius syrichta	89.12	0.00e+00	4778.00
IUUC-Tni-120891	Tetraodon nigroviridis	75.44	0.00e+00	6670.00
IUUC-Tae-125407	Triticum aestivum	47.80	5.00e-48	185.00
IUUC-Tur-126479	Triticum urartu	46.41	2.00e-43	169.00
IUUC-Tme-126930	Tuber melanosporum	42.15	1.00e-47	185.00
IUUC-Tbe-127630	Tupaia belangeri	88.93	0.00e+00	1465.00
IUUC-Ttr-128629	Tursiops truncatus	89.89	0.00e+00	7992.00
IUUC-Vpa-130310	Vicugna pacos	91.08	0.00e+00	7924.00
IUUC-Xtr-131861	Xenopus tropicalis	84.97	0.00e+00	7368.00
IUUC-Xma-133613	Xiphophorus maculatus	78.62	0.00e+00	6826.00
IUUC-Zma-135768	Zea mays	36.22	1.00e-45	179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence