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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046422
UUCD1 version UUC-HoS-00315
Ensembl Protein ID ENSP00000276893.5
UniProt Accession Q96PU4; Q5VYR1; Q5VYR3; Q659C8; Q8TAG7; UHRF2_HUMAN
Genbank Protein ID BAB68317.1; AAM33799.1; CAH74119.1; CAH74119.1; CAI13293.1; CAI13293.1; CAH74120.1; CAH74120.1; CAI13295.1; CAI13295.1; AAH28397.1; CAH56383.1
Protein Name E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2
Genbank Nucleotide ID AB071698; AF274049; AL353718; AL133480; AL133480; AL353718; AL353718; AL133480; AL133480; AL353718; BC028397; AL137728
Gene Name UHRF2; NIRF; RNF107
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000147854.16 ENST00000468435.6 ENSP00000434182.1
ENSG00000147854.16 ENST00000276893.9 ENSP00000276893.5
ENSG00000147854.16 ENST00000381373.3 ENSP00000370778.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19218238; 14741369; 18643997; 23404503
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 12176013; 12826399; 14741369
Classification
Family E-value Score Start End
E3 activity/RING/PHD 4.90e-08 34.7 346 393
E3 activity/RING/RING 0.062 15.5 733 772
ULD/UDP/UBQ/UBQ_PIM 7.80e-18 65.9 1 77
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vCg ++e + + + C++C+ ++H  Cl+++  +++p++e+w+Cp+C+
   Q: 346  SCRVCGGKHEPN-MQLLCDECNVAYHIYCLNPP-LDKVPEEEYWYCPSCK 393
           6*******9977.7889****************.***************8 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C  C +++ ++p+++ C H  ++dClq+      ++ + f+CP Cr
   Q: 733  CVCC-QELVYQPVTTECFHNVCKDCLQRS-----FKAQVFSCPACR 772
           5555.555566***************877.....8**********8 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgke.fel.evseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           m+++v+t +g++ +++ +vs++ t+eel+e++++ ++v pe+q+L y Gk+L++  tL ++++  ++++ l+v++++
   Q: 1    MWIQVRTIDGSKtCTIeDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDP 77
           89**********98887********************************************************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
 E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Protein Sequence
(Fasta)
MWIQVRTIDG SKTCTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD 60
YDVGLNDIIQ LLVRPDPDHL PGTSTQIEAK PCSNSPPKVK KAPRVGPSNQ PSTSARARLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046422|E3,RING;E3,PHD;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGATCCG GCTTGGCGCC GTGACCTCCA TGTGGGAGCT CCAGCTCTAT AAGTAAACAC 60
TCTGCGCGGC GCAGACATGG CCTCTTCCTA TCTTTGAGGC GGTGTCTGCG GCAGCGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046422|E3,RING;E3,PHD;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ
Gene Ontology

GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030154--P:cell differentiation
GO:0008283--P:cell proliferation
GO:0010216--P:maintenance of DNA methylation
GO:0071158--P:positive regulation of cell cycle arrest
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0051726--P:regulation of cell cycle
GO:0090308--P:regulation of methylation-dependent chromatin silencing
KEGG hsa:115426
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001401 Ailuropoda melanoleuca 91.92 0.00e+00 1475.00
IUUC-Aca-005287 Anolis carolinensis 69.19 0.00e+00 1165.00
IUUC-Aly-006276 Arabidopsis lyrata 32.76 5.00e-48 186.00
IUUC-Bta-012710 Bos taurus 90.32 0.00e+00 1371.00
IUUC-Bdi-014586 Brachypodium distachyon 34.90 3.00e-45 177.00
IUUC-Bol-015519 Brassica oleracea 31.53 3.00e-45 176.00
IUUC-Cja-019807 Callithrix jacchus 97.88 0.00e+00 1575.00
IUUC-Cfa-021096 Canis familiaris 91.29 0.00e+00 1439.00
IUUC-Cpo-022368 Cavia porcellus 92.04 0.00e+00 1492.00
IUUC-Csa-023951 Chlorocebus sabaeus 99.13 0.00e+00 1592.00
IUUC-Cho-024857 Choloepus hoffmanni 89.74 0.00e+00 966.00
IUUC-Dno-029950 Dasypus novemcinctus 91.55 0.00e+00 1442.00
IUUC-Ete-032375 Echinops telfairi 86.21 8.00e-145 507.00
IUUC-Eca-033272 Equus caballus 91.97 0.00e+00 1442.00
IUUC-Fca-035570 Felis catus 91.14 0.00e+00 1369.00
IUUC-Fal-037082 Ficedula albicollis 69.18 0.00e+00 1140.00
IUUC-Gmo-038826 Gadus morhua 60.22 0.00e+00 937.00
IUUC-Gga-041062 Gallus gallus 69.47 0.00e+00 1153.00
IUUC-Gac-041859 Gasterosteus aculeatus 62.72 0.00e+00 1014.00
IUUC-Ggo-045639 Gorilla gorilla 99.88 0.00e+00 1607.00
IUUC-Itr-048532 Ictidomys tridecemlineatus 94.40 0.00e+00 1052.00
IUUC-Lpe-050756 Leersia perrieri 31.77 2.00e-43 171.00
IUUC-Loc-052318 Lepisosteus oculatus 64.24 0.00e+00 1075.00
IUUC-Laf-053529 Loxodonta africana 92.41 0.00e+00 1482.00
IUUC-Mcc-055815 Macaca mulatta 99.13 0.00e+00 1594.00
IUUC-Meu-056189 Macropus eugenii 63.75 1.00e-141 497.00
IUUC-Mtr-057930 Medicago truncatula 32.32 3.00e-46 180.00
IUUC-Mmr-060646 Microcebus murinus 93.91 0.00e+00 1499.00
IUUC-Mdo-062659 Monodelphis domestica 71.10 0.00e+00 1176.00
IUUC-Mmu-064198 Mus musculus 90.67 0.00e+00 1489.00
IUUC-Mac-064697 Musa acuminata 32.10 1.00e-45 177.00
IUUC-Mlu-067256 Myotis lucifugus 79.88 0.00e+00 1234.00
IUUC-Nle-069901 Nomascus leucogenys 98.93 0.00e+00 1496.00
IUUC-Opr-070219 Ochotona princeps 90.53 4.00e-139 488.00
IUUC-Ont-072019 Oreochromis niloticus 56.79 0.00e+00 987.00
IUUC-Oan-073109 Ornithorhynchus anatinus 76.74 0.00e+00 722.00
IUUC-Ocu-074748 Oryctolagus cuniculus 89.79 0.00e+00 1325.00
IUUC-Oba-075108 Oryza barthii 32.27 6.00e-44 172.00
IUUC-Obr-076572 Oryza brachyantha 33.17 4.00e-43 169.00
IUUC-Ogl-077177 Oryza glaberrima 32.02 7.00e-44 172.00
IUUC-Ogu-078298 Oryza glumaepatula 32.02 7.00e-44 172.00
IUUC-Oin-079911 Oryza indica 32.27 6.00e-44 172.00
IUUC-Olo-080374 Oryza longistaminata 30.69 4.00e-37 149.00
IUUC-Ome-081137 Oryza meridionalis 30.45 7.00e-37 149.00
IUUC-Opu-083974 Oryza punctata 32.27 7.00e-44 172.00
IUUC-Osa-085339 Oryza sativa 32.02 7.00e-44 172.00
IUUC-Ola-086706 Oryzias latipes 61.79 0.00e+00 977.00
IUUC-Oga-088218 Otolemur garnettii 93.53 0.00e+00 1520.00
IUUC-Oar-090189 Ovis aries 90.92 0.00e+00 1477.00
IUUC-Ptr-091290 Pan troglodytes 99.75 0.00e+00 1605.00
IUUC-Pan-092391 Papio anubis 95.65 0.00e+00 1522.00
IUUC-Psi-093033 Pelodiscus sinensis 69.96 0.00e+00 1112.00
IUUC-Pab-098211 Pongo abelii 99.50 0.00e+00 1597.00
IUUC-Pop-099357 Populus trichocarpa 33.70 3.00e-47 183.00
IUUC-Pca-100531 Procavia capensis 86.36 0.00e+00 1285.00
IUUC-Ppe-101961 Prunus persica 31.99 9.00e-47 181.00
IUUC-Pva-102266 Pteropus vampyrus 91.55 0.00e+00 1484.00
IUUC-Pyt-104740 Pyrenophora triticirepentis 28.85 5.00e-11 63.50
IUUC-Rno-105552 Rattus norvegicus 90.17 0.00e+00 1458.00
IUUC-Sha-106687 Sarcophilus harrisii 70.08 0.00e+00 1069.00
IUUC-Sit-110588 Setaria italica 31.49 3.00e-43 170.00
IUUC-Sly-111415 Solanum lycopersicum 34.22 7.00e-46 179.00
IUUC-Sar-113546 Sorex araneus 83.83 2.00e-139 489.00
IUUC-Sbi-114726 Sorghum bicolor 33.33 2.00e-43 171.00
IUUC-Tgu-116945 Taeniopygia guttata 68.41 0.00e+00 998.00
IUUC-Tru-118292 Takifugu rubripes 62.05 0.00e+00 1003.00
IUUC-Tsy-119249 Tarsius syrichta 94.55 0.00e+00 1425.00
IUUC-Tni-120750 Tetraodon nigroviridis 60.61 0.00e+00 964.00
IUUC-Tbe-127823 Tupaia belangeri 86.54 0.00e+00 1006.00
IUUC-Ttr-128215 Tursiops truncatus 83.79 0.00e+00 1320.00
IUUC-Vpa-130073 Vicugna pacos 89.55 0.00e+00 1447.00
IUUC-Xtr-132771 Xenopus tropicalis 64.04 0.00e+00 1077.00
IUUC-Xma-133888 Xiphophorus maculatus 63.72 0.00e+00 833.00
Created Date 25-Jun-2017

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