iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059556

UUCD1 version

UUC-MeG-00851

Ensembl Protein ID

ENSMGAP00000005728.1

UniProt Accession

G1N296; G1N296_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP47

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005725.1	ENSMGAT00000006470.1	ENSMGAP00000005728.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-75	254.4	175	549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    +++e++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q
   Q: 175  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEESE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQ 257
           6******************************...5555443.5899*********************************9998..9*** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++ 
   Q: 258  HDVQELCRVMFDALEQKW--------------------------KQTEQADLINQLYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRP 320
           ******************..........................678999*************************************95 PP
   S: 179  k.eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
             ++++  s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f  
   Q: 321  YgSNQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSIFID 409
           41334678*****************************************************************************9998 PP
   S: 267  speekqke.....................................................kkkYeLiavvvHsGslssGHYvayvkn. 301
            ++ek+ +                                                     +  YeL++v+vHsGs+ +GHY+a++k+ 
   Q: 410  VEDEKSPQtesctdsgaenegschsdqmsndfsnddgvdegiclesnsaaeriakvgseknSSLYELFSVMVHSGSAAGGHYYACIKSf 498
           86666655777778888888888888888888888888888888888888888888888889**************************5 PP
   S: 302  ekgkWllfdDskVtevkeeevleetg................staYvlfYk 336
           ++++W+ f+D++V+++++e+++++ g                ++aY+l+Y+
   Q: 499  SDDQWYSFNDQHVSKITQEDIKKTYGgssgsrgyyssafassTNAYMLIYR 549
           5666*******************888************************8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

DMFWSCRQST FAEMKKKFSQ VESAAEEPRV LCIIQDTTNS KTVNERITLN VPASTPLKKL 60
FEDIASKVGY VNGTFDLVWG NGDNVTDMTP IDQNSDKSIL DAGFEPGKKN FLHLTDKDGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATATGTTTT GGAGTTGCAG ACAAAGTACC TTTGCTGAAA TGAAGAAGAA ATTTTCACAG 60
GTAGATAGAT GAAATCAACT TTATAAAATA ATTGAAATTC ACAGTAACAG CATGATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF14560--Ubiquitin_2
PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006284--P:base-excision repair
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	87.63	0.00e+00	2310.00
IUUC-Apl-003486	Anas platyrhynchos	95.67	0.00e+00	2505.00
IUUC-Aca-005061	Anolis carolinensis	90.10	0.00e+00	2410.00
IUUC-Ame-011206	Astyanax mexicanus	80.13	0.00e+00	2087.00
IUUC-Bta-012942	Bos taurus	88.33	0.00e+00	2364.00
IUUC-Cel-018600	Caenorhabditis elegans	37.79	2.00e-121	430.00
IUUC-Cja-018950	Callithrix jacchus	89.88	0.00e+00	2205.00
IUUC-Cfa-020299	Canis familiaris	89.63	0.00e+00	2347.00
IUUC-Cpo-021943	Cavia porcellus	88.70	0.00e+00	2350.00
IUUC-Csa-023285	Chlorocebus sabaeus	89.66	0.00e+00	2332.00
IUUC-Cho-025006	Choloepus hoffmanni	82.06	0.00e+00	2033.00
IUUC-Cin-025145	Ciona intestinalis	41.23	0.00e+00	701.00
IUUC-Csv-025839	Ciona savignyi	49.47	3.00e-162	565.00
IUUC-Dre-027959	Danio rerio	80.92	0.00e+00	2035.00
IUUC-Dno-030023	Dasypus novemcinctus	86.61	0.00e+00	2248.00
IUUC-Dor-030994	Dipodomys ordii	87.29	0.00e+00	861.00
IUUC-Dme-031604	Drosophila melanogaster	48.87	8.00e-146	511.00
IUUC-Ete-032596	Echinops telfairi	75.08	0.00e+00	756.00
IUUC-Eca-033913	Equus caballus	88.42	0.00e+00	2372.00
IUUC-Eeu-034518	Erinaceus europaeus	82.59	0.00e+00	1967.00
IUUC-Fca-035997	Felis catus	89.08	0.00e+00	2357.00
IUUC-Fal-037088	Ficedula albicollis	95.24	0.00e+00	2203.00
IUUC-Gmo-038920	Gadus morhua	77.34	0.00e+00	1995.00
IUUC-Gga-040953	Gallus gallus	98.17	0.00e+00	2543.00
IUUC-Gac-042400	Gasterosteus aculeatus	77.92	0.00e+00	1985.00
IUUC-Ggo-044820	Gorilla gorilla	87.67	0.00e+00	2283.00
IUUC-Hsa-046634	Homo sapiens	89.29	0.00e+00	2356.00
IUUC-Lch-050440	Latimeria chalumnae	85.03	0.00e+00	2268.00
IUUC-Loc-051904	Lepisosteus oculatus	83.83	0.00e+00	2215.00
IUUC-Laf-053760	Loxodonta africana	88.86	0.00e+00	2364.00
IUUC-Mcc-054637	Macaca mulatta	89.44	0.00e+00	2363.00
IUUC-Meu-056904	Macropus eugenii	89.57	0.00e+00	1585.00
IUUC-Mmr-061192	Microcebus murinus	89.36	0.00e+00	2358.00
IUUC-Mdo-061929	Monodelphis domestica	89.95	0.00e+00	2379.00
IUUC-Mmu-063726	Mus musculus	87.60	0.00e+00	2340.00
IUUC-Mpu-066014	Mustela putorius furo	89.67	0.00e+00	2338.00
IUUC-Mlu-067232	Myotis lucifugus	88.73	0.00e+00	2347.00
IUUC-Nle-069619	Nomascus leucogenys	89.51	0.00e+00	2328.00
IUUC-Opr-070224	Ochotona princeps	84.73	0.00e+00	1043.00
IUUC-Ont-071384	Oreochromis niloticus	79.61	0.00e+00	2037.00
IUUC-Oan-073208	Ornithorhynchus anatinus	84.62	0.00e+00	2257.00
IUUC-Ocu-074285	Oryctolagus cuniculus	89.07	0.00e+00	2355.00
IUUC-Ola-087051	Oryzias latipes	79.18	0.00e+00	1974.00
IUUC-Oga-088928	Otolemur garnettii	88.99	0.00e+00	2349.00
IUUC-Oar-090215	Ovis aries	88.43	0.00e+00	2372.00
IUUC-Ptr-091035	Pan troglodytes	89.29	0.00e+00	2359.00
IUUC-Pan-092377	Papio anubis	88.85	0.00e+00	2339.00
IUUC-Pfo-096722	Poecilia formosa	78.97	0.00e+00	2017.00
IUUC-Pab-098723	Pongo abelii	89.29	0.00e+00	2360.00
IUUC-Pca-100105	Procavia capensis	85.03	0.00e+00	2171.00
IUUC-Pva-102514	Pteropus vampyrus	89.38	0.00e+00	887.00
IUUC-Rno-105384	Rattus norvegicus	87.38	0.00e+00	2305.00
IUUC-Sha-106982	Sarcophilus harrisii	87.87	0.00e+00	2326.00
IUUC-Sar-113723	Sorex araneus	82.12	0.00e+00	887.00
IUUC-Ssc-115671	Sus scrofa	89.40	0.00e+00	1895.00
IUUC-Tgu-116722	Taeniopygia guttata	93.62	0.00e+00	2440.00
IUUC-Tru-118380	Takifugu rubripes	77.01	0.00e+00	2017.00
IUUC-Tsy-119646	Tarsius syrichta	83.05	0.00e+00	2150.00
IUUC-Tni-120762	Tetraodon nigroviridis	77.24	0.00e+00	2021.00
IUUC-Tbe-127861	Tupaia belangeri	87.38	0.00e+00	2184.00
IUUC-Ttr-129254	Tursiops truncatus	81.89	0.00e+00	1320.00
IUUC-Vpa-130141	Vicugna pacos	89.52	0.00e+00	1098.00
IUUC-Xtr-132700	Xenopus tropicalis	80.80	0.00e+00	2154.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence