iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000058317.11	ENSMUST00000176555.7	ENSMUSP00000134919.1
ENSMUSG00000058317.11	ENSMUST00000150727.7	ENSMUSP00000115738.1
ENSMUSG00000058317.11	ENSMUST00000175643.7	ENSMUSP00000135674.1
ENSMUSG00000058317.11	ENSMUST00000176843.7	ENSMUSP00000135622.1
ENSMUSG00000058317.11	ENSMUST00000151926.7	ENSMUSP00000118321.1
ENSMUSG00000058317.11	ENSMUST00000177259.7	ENSMUSP00000135573.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.00e-50	169.7	59	194

Active Site

Position(s)	Description	Evidence
139	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk  
   Q: 59   RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILK-- 144
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++Wspal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 145  DNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 194
           *********************************************99985 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Protein Sequence
(Fasta)

MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA AKLSTSAKRI 60
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGCTAGC AGCCCTGGAC AGGACTAGGC ACCGCAGGAC CTTCCCTGCA GCAGTTAAGG 60
GGTAAAATGT GGCTTCACCC GGGCCCACGC GAAGTTTTCC AACAGCGGTG CAGGTGGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0032020--P:ISG15-protein conjugation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

mmu:218793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005044	Anolis carolinensis	97.51	3.00e-97	347.00
IUUC-Ame-011419	Astyanax mexicanus	95.80	2.00e-82	298.00
IUUC-Cfa-020524	Canis familiaris	96.02	2.00e-89	321.00
IUUC-Cre-022791	Chlamydomonas reinhardtii	80.13	1.00e-71	261.00
IUUC-Cho-024986	Choloepus hoffmanni	89.05	2.00e-86	311.00
IUUC-Dre-027449	Danio rerio	89.05	9.00e-89	319.00
IUUC-Dno-029130	Dasypus novemcinctus	100.00	1.00e-74	271.00
IUUC-Dme-032042	Drosophila melanogaster	87.65	2.00e-84	305.00
IUUC-Eeu-034931	Erinaceus europaeus	95.52	5.00e-93	333.00
IUUC-Fca-035425	Felis catus	99.00	4.00e-85	306.00
IUUC-Fal-037043	Ficedula albicollis	98.01	2.00e-85	307.00
IUUC-Gmo-039645	Gadus morhua	90.64	2.00e-91	328.00
IUUC-Gga-040236	Gallus gallus	100.00	4.00e-85	306.00
IUUC-Gac-041661	Gasterosteus aculeatus	91.04	8.00e-91	325.00
IUUC-Hsa-046767	Homo sapiens	99.50	7.00e-86	309.00
IUUC-Loc-052673	Lepisosteus oculatus	94.03	6.00e-94	336.00
IUUC-Mcc-055072	Macaca mulatta	99.50	7.00e-86	309.00
IUUC-Meu-056612	Macropus eugenii	93.43	3.00e-81	294.00
IUUC-Mmr-060629	Microcebus murinus	99.50	7.00e-86	309.00
IUUC-Mlu-067897	Myotis lucifugus	99.00	7.00e-86	309.00
IUUC-Nle-069421	Nomascus leucogenys	99.50	7.00e-86	309.00
IUUC-Opr-071192	Ochotona princeps	82.88	2.00e-45	174.00
IUUC-Ont-071325	Oreochromis niloticus	91.54	1.00e-91	328.00
IUUC-Oan-073704	Ornithorhynchus anatinus	100.00	1.00e-74	270.00
IUUC-Pfo-097071	Poecilia formosa	86.89	2.00e-89	321.00
IUUC-Pab-098017	Pongo abelii	99.50	7.00e-86	309.00
IUUC-Pca-100367	Procavia capensis	92.04	3.00e-88	317.00
IUUC-Pva-102561	Pteropus vampyrus	99.00	7.00e-86	309.00
IUUC-Sar-112946	Sorex araneus	90.05	3.00e-74	270.00
IUUC-Tru-118527	Takifugu rubripes	95.77	2.00e-81	294.00
IUUC-Tsy-119002	Tarsius syrichta	95.63	4.00e-82	296.00
IUUC-Tni-119832	Tetraodon nigroviridis	73.11	2.00e-84	304.00
IUUC-Ttr-128358	Tursiops truncatus	99.50	7.00e-86	309.00
IUUC-Vpa-130232	Vicugna pacos	98.58	6.00e-81	293.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence