iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096142

Ensembl Protein ID

ENSPFOP00000018077.2

UniProt Accession

A0A087YJ74; A0A087YJ74_POEFO

Genbank Protein ID

ENSPFOP00000018077

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01022634

Gene Name

SMURF2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000017936.2	ENSPFOT00000018099.2	ENSPFOP00000018077.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-128	427.9	438	770

Active Site

Position(s)	Description	Evidence
739	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 438  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 525
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+  +eLkp+G++ipVt++ k+eYv+l+v+
   Q: 526  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIPHELKPNGKSIPVTEDTKKEYVRLYVN 610
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id+ d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 611  WRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIADWKSNTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 698
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da+ ++lP+++TCfn++++P+Y+s+++l++kLl+Aieet gF +
   Q: 699  TGSSRVPLQGFKALQgaagPRLFTIHQiDANANNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAV 770
           ***************************99999**************************************76 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

SAEPQARPKG HVSTFLFLVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVRNTLDP 60
KWNQHYDLYI GKSDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAINRLKD TGYQRLDLNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCGGAGC CACAGGCACG TCCAAAAGGT CACGTCTCCA CGTGCAGTTA ACAATAGTCA 60
CTCCACTGCT GCCGACTGGG TGTCTTTGTT GCTATATTTA GCAACTTTTC AGGGAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gac-041983	Gasterosteus aculeatus	93.55	0.00e+00	1465.00
IUUC-Ont-072243	Oreochromis niloticus	96.46	0.00e+00	1508.00
IUUC-Ola-087161	Oryzias latipes	88.38	0.00e+00	1306.00
IUUC-Spo-108171	Schizosaccharomyces pombe	39.90	8.00e-160	557.00
IUUC-Tru-118497	Takifugu rubripes	92.84	0.00e+00	1412.00
IUUC-Tni-120781	Tetraodon nigroviridis	91.64	0.00e+00	1240.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence