iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005272

UUCD1 version

UUC-AnC-00241

Ensembl Protein ID

ENSACAP00000017527.3

UniProt Accession

H9GPQ0; H9GPQ0_ANOCA

Protein Name

Uncharacterized protein

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000017797.3	ENSACAT00000017873.3	ENSACAP00000017527.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.50e-16	57.9	3	64
E3 adaptor/Cullin RING/DCX/DWD	1.30e-31	107.2	390	423
UBD/Beta-Prp	4.40e-53	180.3	231	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +Pv++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPVNNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++   +cv+++++he+ v+ ls++++gd
   Q: 231  PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPGVSCVQVVRAHESAVTGLSLHATGD 319
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l
   Q: 320  YLLSSSDDQYWAFSDIQTGRVLTKvTDETSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYL 407
           **********************997777777799************************************9.***************** PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           +++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +++i
   Q: 408  ATAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQVYI 461
           ***************999999999866527*******************99987 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PVNNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATTCCAGC CATGCAAGCC TTCGACAACA TGAGAATGAC ATTAACTGCC TCGGTTAAAC 60
GCTACAGAGG TCTGGGCTTC GCCTTCTTGT GAGAAATCCA CCATACTCTG CCAGAGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

KEGG

acs:100567086

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	40.78	2.00e-98	353.00
IUUC-Aml-001230	Ailuropoda melanoleuca	94.19	0.00e+00	946.00
IUUC-Atr-002594	Amborella trichopoda	44.32	1.00e-119	423.00
IUUC-Apl-003686	Anas platyrhynchos	87.15	0.00e+00	729.00
IUUC-Aly-005586	Arabidopsis lyrata	43.74	1.00e-117	416.00
IUUC-Ath-007696	Arabidopsis thaliana	44.04	2.00e-115	409.00
IUUC-Acl-008335	Aspergillus clavatus	36.34	6.00e-68	251.00
IUUC-Afl-008527	Aspergillus flavus	37.97	2.00e-72	266.00
IUUC-Afu-008957	Aspergillus fumigatus	38.74	5.00e-79	288.00
IUUC-Ani-009280	Aspergillus nidulans	38.66	6.00e-67	248.00
IUUC-Ang-009746	Aspergillus niger	36.50	4.00e-67	248.00
IUUC-Aor-009905	Aspergillus oryzae	37.76	5.00e-76	278.00
IUUC-Ate-010412	Aspergillus terreus	37.55	9.00e-66	244.00
IUUC-Ame-011561	Astyanax mexicanus	84.58	2.00e-110	391.00
IUUC-Bgr-012283	Blumeria graminis	32.85	2.00e-56	213.00
IUUC-Bta-013242	Bos taurus	97.62	0.00e+00	1003.00
IUUC-Bci-013901	Botrytis cinerea	34.59	5.00e-66	244.00
IUUC-Bdi-014277	Brachypodium distachyon	45.00	7.00e-124	437.00
IUUC-Bol-016207	Brassica oleracea	45.35	4.00e-118	418.00
IUUC-Bra-017650	Brassica rapa	43.70	1.00e-117	416.00
IUUC-Cel-018271	Caenorhabditis elegans	51.78	5.00e-152	530.00
IUUC-Cja-019879	Callithrix jacchus	97.03	0.00e+00	995.00
IUUC-Cfa-020175	Canis familiaris	97.22	0.00e+00	1000.00
IUUC-Cpo-022379	Cavia porcellus	97.82	0.00e+00	1004.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.55	8.00e-99	353.00
IUUC-Csa-023500	Chlorocebus sabaeus	97.42	0.00e+00	1001.00
IUUC-Cho-025065	Choloepus hoffmanni	85.21	8.00e-146	509.00
IUUC-Cin-025699	Ciona intestinalis	68.58	6.00e-175	606.00
IUUC-Csv-026128	Ciona savignyi	65.38	0.00e+00	677.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.60	6.00e-66	244.00
IUUC-Cne-026860	Cryptococcus neoformans	37.38	3.00e-93	335.00
IUUC-Dre-028187	Danio rerio	85.35	0.00e+00	865.00
IUUC-Dno-029453	Dasypus novemcinctus	97.22	0.00e+00	999.00
IUUC-Dor-030150	Dipodomys ordii	97.06	3.00e-126	444.00
IUUC-Dse-031220	Dothistroma septosporum	31.94	3.00e-58	219.00
IUUC-Dme-031906	Drosophila melanogaster	65.94	0.00e+00	664.00
IUUC-Ete-033035	Echinops telfairi	84.92	0.00e+00	849.00
IUUC-Eca-033478	Equus caballus	97.42	0.00e+00	1001.00
IUUC-Eeu-034974	Erinaceus europaeus	97.87	0.00e+00	674.00
IUUC-Fca-036194	Felis catus	96.41	0.00e+00	989.00
IUUC-Fal-037417	Ficedula albicollis	97.02	0.00e+00	998.00
IUUC-Fox-037922	Fusarium oxysporum	34.82	3.00e-64	239.00
IUUC-Fso-038256	Fusarium solani	33.94	4.00e-65	241.00
IUUC-Gmo-038713	Gadus morhua	86.73	0.00e+00	878.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.82	2.00e-54	206.00
IUUC-Gga-041143	Gallus gallus	96.63	0.00e+00	995.00
IUUC-Gac-042129	Gasterosteus aculeatus	85.54	0.00e+00	893.00
IUUC-Gma-044273	Glycine max	45.19	7.00e-121	427.00
IUUC-Ggo-045262	Gorilla gorilla	97.42	0.00e+00	1001.00
IUUC-Hsa-046036	Homo sapiens	97.42	0.00e+00	1001.00
IUUC-Hvu-047442	Hordeum vulgare	43.75	3.00e-68	251.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	97.02	0.00e+00	963.00
IUUC-Lch-050105	Latimeria chalumnae	89.88	0.00e+00	939.00
IUUC-Lpe-050976	Leersia perrieri	44.81	4.00e-120	424.00
IUUC-Loc-052042	Lepisosteus oculatus	74.63	0.00e+00	666.00
IUUC-Lma-053143	Leptosphaeria maculans	34.58	9.00e-64	238.00
IUUC-Laf-053451	Loxodonta africana	93.86	0.00e+00	988.00
IUUC-Mcc-055786	Macaca mulatta	97.42	0.00e+00	1001.00
IUUC-Meu-056161	Macropus eugenii	97.51	5.00e-139	487.00
IUUC-Mor-057215	Magnaporthe oryzae	33.66	2.00e-56	213.00
IUUC-Mpo-057419	Magnaporthe poae	31.67	1.00e-50	193.00
IUUC-Mtr-057756	Medicago truncatula	44.66	2.00e-116	412.00
IUUC-Mla-059085	Melampsora laricipopulina	37.88	4.00e-86	311.00
IUUC-Mga-060158	Meleagris gallopavo	89.78	0.00e+00	881.00
IUUC-Mvi-060441	Microbotryum violaceum	38.36	2.00e-79	289.00
IUUC-Mmr-061085	Microcebus murinus	97.42	0.00e+00	1001.00
IUUC-Mdo-061804	Monodelphis domestica	97.42	0.00e+00	1001.00
IUUC-Mmu-063608	Mus musculus	93.88	0.00e+00	989.00
IUUC-Mac-064972	Musa acuminata	44.81	1.00e-117	416.00
IUUC-Mpu-065700	Mustela putorius furo	97.22	0.00e+00	1000.00
IUUC-Mlu-068223	Myotis lucifugus	93.45	0.00e+00	981.00
IUUC-Nfi-068504	Neosartorya fischeri	37.97	7.00e-78	284.00
IUUC-Ncr-068729	Neurospora crassa	36.69	2.00e-64	239.00
IUUC-Nle-069754	Nomascus leucogenys	97.42	0.00e+00	1001.00
IUUC-Opr-070621	Ochotona princeps	93.36	0.00e+00	937.00
IUUC-Ont-071377	Oreochromis niloticus	85.54	0.00e+00	872.00
IUUC-Oan-073498	Ornithorhynchus anatinus	72.00	4.00e-121	427.00
IUUC-Ocu-074182	Oryctolagus cuniculus	93.52	0.00e+00	988.00
IUUC-Oba-075509	Oryza barthii	45.30	1.00e-122	433.00
IUUC-Obr-076480	Oryza brachyantha	45.49	4.00e-123	434.00
IUUC-Ogl-077052	Oryza glaberrima	45.30	1.00e-122	433.00
IUUC-Ogu-078919	Oryza glumaepatula	44.91	1.00e-122	433.00
IUUC-Oin-079357	Oryza indica	44.40	2.00e-116	412.00
IUUC-Olo-080376	Oryza longistaminata	44.06	8.00e-110	390.00
IUUC-Ome-081973	Oryza meridionalis	44.26	2.00e-110	392.00
IUUC-Oni-082849	Oryza nivara	45.49	2.00e-123	435.00
IUUC-Opu-083243	Oryza punctata	45.11	6.00e-122	431.00
IUUC-Oru-084613	Oryza rufipogon	45.00	2.00e-122	432.00
IUUC-Osa-085407	Oryza sativa	45.28	5.00e-122	431.00
IUUC-Ola-086566	Oryzias latipes	84.71	0.00e+00	863.00
IUUC-Olu-087757	Ostreococcus lucimarinus	40.32	4.00e-96	344.00
IUUC-Oga-089010	Otolemur garnettii	93.10	0.00e+00	949.00
IUUC-Oar-089638	Ovis aries	97.62	0.00e+00	1003.00
IUUC-Ptr-091141	Pan troglodytes	97.42	0.00e+00	1001.00
IUUC-Pan-092662	Papio anubis	97.42	0.00e+00	1001.00
IUUC-Psi-093777	Pelodiscus sinensis	96.42	0.00e+00	819.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.44	8.00e-65	241.00
IUUC-Ppa-095841	Physcomitrella patens	44.64	1.00e-121	429.00
IUUC-Pfo-096390	Poecilia formosa	84.75	0.00e+00	872.00
IUUC-Pab-098250	Pongo abelii	95.88	0.00e+00	936.00
IUUC-Pop-099854	Populus trichocarpa	44.98	9.00e-121	427.00
IUUC-Pca-100553	Procavia capensis	97.22	0.00e+00	994.00
IUUC-Ppe-101383	Prunus persica	43.44	3.00e-113	402.00
IUUC-Pva-102189	Pteropus vampyrus	97.42	0.00e+00	1002.00
IUUC-Pgr-103304	Puccinia graminis	36.36	3.00e-83	301.00
IUUC-Ptt-103984	Puccinia triticina	36.74	9.00e-88	317.00
IUUC-Pte-104385	Pyrenophora teres	33.97	9.00e-70	257.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	34.39	5.00e-71	261.00
IUUC-Rno-105581	Rattus norvegicus	97.42	0.00e+00	1002.00
IUUC-Sha-107071	Sarcophilus harrisii	93.35	0.00e+00	988.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.65	1.00e-35	144.00
IUUC-Spo-108315	Schizosaccharomyces pombe	33.33	4.00e-46	178.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.68	6.00e-65	241.00
IUUC-Smo-109648	Selaginella moellendorffii	45.74	2.00e-122	432.00
IUUC-Sit-109873	Setaria italica	43.76	1.00e-119	423.00
IUUC-Sly-111673	Solanum lycopersicum	44.96	1.00e-113	403.00
IUUC-Stu-112125	Solanum tuberosum	44.77	7.00e-113	400.00
IUUC-Sbi-114696	Sorghum bicolor	41.98	1.00e-108	386.00
IUUC-Sre-115134	Sporisorium reilianum	31.65	2.00e-71	263.00
IUUC-Ssc-116260	Sus scrofa	97.42	0.00e+00	1001.00
IUUC-Tgu-116533	Taeniopygia guttata	97.02	0.00e+00	998.00
IUUC-Tru-117800	Takifugu rubripes	84.95	0.00e+00	896.00
IUUC-Tsy-118980	Tarsius syrichta	91.63	0.00e+00	905.00
IUUC-Tni-120334	Tetraodon nigroviridis	69.11	0.00e+00	708.00
IUUC-Tca-121807	Theobroma cacao	45.65	2.00e-122	432.00
IUUC-Tre-121920	Trichoderma reesei	32.98	3.00e-62	232.00
IUUC-Tvi-122294	Trichoderma virens	32.84	9.00e-55	207.00
IUUC-Tae-125713	Triticum aestivum	44.91	6.00e-125	441.00
IUUC-Tur-126664	Triticum urartu	40.42	2.00e-114	406.00
IUUC-Tme-127026	Tuber melanosporum	34.68	2.00e-69	256.00
IUUC-Tbe-127582	Tupaia belangeri	97.57	0.00e+00	671.00
IUUC-Ttr-128313	Tursiops truncatus	97.22	0.00e+00	993.00
IUUC-Uma-129626	Ustilago maydis	33.33	2.00e-74	273.00
IUUC-Vda-129699	Verticillium dahliae	34.99	9.00e-68	250.00
IUUC-Vpa-130593	Vicugna pacos	97.14	0.00e+00	891.00
IUUC-Vvi-131668	Vitis vinifera	44.59	1.00e-120	426.00
IUUC-Xtr-132186	Xenopus tropicalis	85.88	0.00e+00	770.00
IUUC-Xma-133212	Xiphophorus maculatus	84.55	0.00e+00	867.00
IUUC-Yli-134607	Yarrowia lipolytica	56.82	3.00e-41	160.00
IUUC-Zma-135662	Zea mays	44.62	5.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence