iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065944

Ensembl Protein ID

ENSMPUP00000001564.1

UniProt Accession

M3XR64; M3XR64_MUSPF

Genbank Protein ID

ENSMPUP00000001564

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01068037

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000001580.1	ENSMPUT00000001597.1	ENSMPUP00000001564.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.50e-87	292.8	191	814

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellk 75
           +G++NlgNtC++N+v+Q L++   l+el++e+k++ ++ +                 ++ g+l+++l  +++++ +++k+  sp+ l++
   Q: 191  KGISNLGNTCFFNAVMQNLAQSYILMELMNENKENGTKLK-IfpspdsqldpliveLSSPGPLTSALLVFLHSMKETEKGPLSPKVLFN 278
           59*****************************555555444.24667777777777777777**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcle 158
           +l+++a++f++++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ de      + +  +  + ++i+++F g+l+s+++c+e
   Q: 279  QLCQKAPRFKSFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADEdtrkkvKAYGREGVKMNFIDRIFIGELTSTVMCEE 367
           ********************************99888888888888888877773333334445555555******************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.............................................................. 185
           c+n+ss ++pf+d+slp+ +++ +k+                                                               
   Q: 368  CANISSVNDPFIDISLPIIEERVSKPVllgrmskcrslqatdngqysdtvtientpqpratknqssskdknqlvhgrkcvrkwssgedr 456
           **********************98777************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 457  avvgprkrgppelngaspaaastantesltesategserdagpsessadadseasesesaseqpvlsasprgcrvqprapspqppaggp 545
           ***************************************************************************************** PP
   S: 186  ...........................................................................slqdcLesftkeee 199
                                                                                      slq+c+ +ft+ e 
   Q: 546  ptrepgrgeervaealselrlsspvpgerdfdredrpqrvpssacsseekrvlsprppnafqtlsrsyvtaskecSLQSCFYQFTSMEL 634
           ***************************************************************************************** PP
   S: 200  legenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl Ldl+pfc+ ++
   Q: 635  LMGNNKLLCENCTEKKRrhqketgsaekkaegvytnARKQLLISAVPVILILHLKRF--HQAGLSLRKVNRHVDFPLVLDLAPFCSATC 721
           *************88888999999999999999999*********************..9999************************99 PP
   S: 270  ekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgsta 330
           +++++  k+ Y L++vv HsGs+++GHY+ayvk                           ++g+W++++D++V++v+e++ l+   ++a
   Q: 722  KNVSVgdKVLYGLYGVVEHSGSMRGGHYTAYVKVrtpsrkllqhitgktyvpdlkepdseSTGQWVHVSDTYVQVVPESRALS---AQA 807
           998777799*************************999999999999999999999998888999*******************...*** PP
   S: 331  YvlfYkr 337
           Y+lfY+r
   Q: 808  YLLFYER 814
           *****98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MRVKEPSRAL PERAKRTKRP ALPHDEDSSD DIAAGFTCQH VSHAISVNHV KKAIAENVLS 60
VCSECLKERR CCEGRPVLPS DIWLCLKCGF QGCGRNSEGH HSLKHYKSWR TESHCITVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTTTTTCA TAATAAAAAC GTGGGGAAAA ACCCCACAAA AAATGCAGTA TAGCTTAAAA 60
CAATTTCTGT CAGTCATTGC TAGGTCATAC GGTGCAGGTA GAAGGGCTCA TGTTGTGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	82.58	0.00e+00	1269.00
IUUC-Apl-003512	Anas platyrhynchos	64.82	0.00e+00	1013.00
IUUC-Aca-004284	Anolis carolinensis	59.76	0.00e+00	939.00
IUUC-Ame-010735	Astyanax mexicanus	67.92	8.00e-85	307.00
IUUC-Bta-012880	Bos taurus	79.19	0.00e+00	1236.00
IUUC-Cja-019144	Callithrix jacchus	76.16	0.00e+00	1236.00
IUUC-Cfa-020971	Canis familiaris	87.45	0.00e+00	801.00
IUUC-Cpo-022497	Cavia porcellus	67.80	0.00e+00	1044.00
IUUC-Csa-023910	Chlorocebus sabaeus	74.58	0.00e+00	1120.00
IUUC-Cho-024358	Choloepus hoffmanni	61.78	1.00e-114	406.00
IUUC-Dre-028106	Danio rerio	60.15	5.00e-145	508.00
IUUC-Dno-029456	Dasypus novemcinctus	69.08	0.00e+00	631.00
IUUC-Dor-030438	Dipodomys ordii	60.90	0.00e+00	891.00
IUUC-Dme-031870	Drosophila melanogaster	44.00	8.00e-36	145.00
IUUC-Ete-032736	Echinops telfairi	63.34	0.00e+00	914.00
IUUC-Eca-034211	Equus caballus	79.71	0.00e+00	1293.00
IUUC-Eeu-034797	Erinaceus europaeus	77.39	1.00e-86	313.00
IUUC-Fca-035947	Felis catus	81.81	0.00e+00	1209.00
IUUC-Fal-037199	Ficedula albicollis	64.71	0.00e+00	883.00
IUUC-Gmo-039228	Gadus morhua	60.76	1.00e-138	487.00
IUUC-Gga-040823	Gallus gallus	61.02	3.00e-161	561.00
IUUC-Gac-042406	Gasterosteus aculeatus	60.20	1.00e-136	480.00
IUUC-Ggo-045402	Gorilla gorilla	75.82	0.00e+00	1206.00
IUUC-Hsa-046430	Homo sapiens	75.92	0.00e+00	1213.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	75.74	0.00e+00	677.00
IUUC-Lch-049547	Latimeria chalumnae	57.83	0.00e+00	894.00
IUUC-Loc-052842	Lepisosteus oculatus	55.07	0.00e+00	868.00
IUUC-Laf-053988	Loxodonta africana	76.95	0.00e+00	1231.00
IUUC-Mcc-055491	Macaca mulatta	71.64	0.00e+00	1138.00
IUUC-Meu-056256	Macropus eugenii	57.88	2.00e-167	582.00
IUUC-Mla-059026	Melampsora laricipopulina	32.04	8.00e-17	82.00
IUUC-Mga-059833	Meleagris gallopavo	57.87	2.00e-163	568.00
IUUC-Mmr-060952	Microcebus murinus	75.55	0.00e+00	1194.00
IUUC-Mdo-062642	Monodelphis domestica	65.10	0.00e+00	1034.00
IUUC-Mmu-063945	Mus musculus	74.69	0.00e+00	1180.00
IUUC-Mlu-067049	Myotis lucifugus	78.75	0.00e+00	1225.00
IUUC-Nle-069828	Nomascus leucogenys	75.95	0.00e+00	1210.00
IUUC-Opr-070672	Ochotona princeps	66.76	2.00e-134	473.00
IUUC-Ont-072121	Oreochromis niloticus	51.90	4.00e-135	475.00
IUUC-Oan-073656	Ornithorhynchus anatinus	63.70	0.00e+00	993.00
IUUC-Ocu-074323	Oryctolagus cuniculus	74.85	0.00e+00	1174.00
IUUC-Ola-087238	Oryzias latipes	53.05	0.00e+00	794.00
IUUC-Oga-088379	Otolemur garnettii	71.19	0.00e+00	1118.00
IUUC-Oar-089718	Ovis aries	79.24	0.00e+00	1236.00
IUUC-Ptr-091358	Pan troglodytes	76.16	0.00e+00	1216.00
IUUC-Pan-092023	Papio anubis	75.55	0.00e+00	1210.00
IUUC-Psi-093256	Pelodiscus sinensis	63.72	0.00e+00	960.00
IUUC-Pfo-097285	Poecilia formosa	50.30	0.00e+00	700.00
IUUC-Pab-098539	Pongo abelii	75.92	0.00e+00	1212.00
IUUC-Pca-100610	Procavia capensis	65.76	0.00e+00	887.00
IUUC-Pva-102985	Pteropus vampyrus	74.54	0.00e+00	1181.00
IUUC-Rno-105538	Rattus norvegicus	72.96	0.00e+00	1181.00
IUUC-Sha-107022	Sarcophilus harrisii	68.60	4.00e-173	602.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	30.85	2.00e-19	90.90
IUUC-Spo-108149	Schizosaccharomyces pombe	30.66	1.00e-20	95.50
IUUC-Sar-113637	Sorex araneus	78.21	0.00e+00	750.00
IUUC-Ssc-115870	Sus scrofa	78.95	0.00e+00	1285.00
IUUC-Tgu-116907	Taeniopygia guttata	64.98	0.00e+00	1016.00
IUUC-Tru-117835	Takifugu rubripes	44.64	8.00e-108	384.00
IUUC-Tsy-118869	Tarsius syrichta	76.34	0.00e+00	1064.00
IUUC-Tni-119716	Tetraodon nigroviridis	51.88	9.00e-96	344.00
IUUC-Tbe-128041	Tupaia belangeri	61.08	0.00e+00	889.00
IUUC-Ttr-128901	Tursiops truncatus	77.48	0.00e+00	1234.00
IUUC-Vpa-130331	Vicugna pacos	79.35	0.00e+00	1162.00
IUUC-Xtr-131794	Xenopus tropicalis	50.12	0.00e+00	750.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence