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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046770
Ensembl Protein ID ENSP00000288912.4
UniProt Accession Q8TBY9; C9J1W2; Q8IYA3; Q8N898; Q8NDE7; CF251_HUMAN
Genbank Protein ID AAH28421.1; AAH36233.1; CAD38786.1
Protein Name Cilia- and flagella-associated protein 251; WD repeat-containing protein 66
Genbank Nucleotide ID AC069503; BC036233; AK097102
Gene Name WDR66; CFAP251
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000158023.9 ENST00000288912.8 ENSP00000288912.4
ENSG00000158023.9 ENST00000397454.2 ENSP00000380595.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.50e-06 27.8 452 477
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclafsdtllvsGsdDgtikvWDlrt 32
           s++ l++  t ++s++  g++ vWD+++
   Q: 452  SIFHLNL--TQILSATMEGKLVVWDIHR 477
           6777777..99**************876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May regulate cilium motility through its role in the assembly of the axonemal radial spokes.
 May regulate cilium motility through its role in the assembly of the axonemal radial spokes.
Protein Sequence
(Fasta)
MSDAAEAPRE ATGENGETEM KEEEEPNPNY KEVEDPQQES KDDTIAWRES QEEERKTGEE 60
EGEEEGKEDK KIVMEETEEK AGEVQEKEAS GIQEETTVEP QEVTASMIRL ETQITDSQSI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046770|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTATCCTTT CTTTTTTATT TTAAGATGTA TGCATATTAA TCAATTTACC ATCACTGGGG 60
CATGGCAGTG TGGGCGGGGA GAATTATTCA CATTCTCCTA AAATGACAGC AGCAGAGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046770|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011992--EF-hand-dom_pair
IPR027295--Quinoprotein_ADH-like_fam
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005930--C:axoneme
KEGG hsa:144406
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002305 Ailuropoda melanoleuca 81.74 0.00e+00 1790.00
IUUC-Apl-003833 Anas platyrhynchos 56.28 0.00e+00 1011.00
IUUC-Ame-011318 Astyanax mexicanus 48.17 0.00e+00 874.00
IUUC-Bta-013319 Bos taurus 79.79 0.00e+00 1719.00
IUUC-Cja-019874 Callithrix jacchus 89.56 0.00e+00 2084.00
IUUC-Cfa-021224 Canis familiaris 79.67 0.00e+00 1836.00
IUUC-Cpo-022038 Cavia porcellus 70.99 0.00e+00 1395.00
IUUC-Cre-022950 Chlamydomonas reinhardtii 27.82 6.00e-62 232.00
IUUC-Csa-024266 Chlorocebus sabaeus 85.78 0.00e+00 1855.00
IUUC-Cin-025361 Ciona intestinalis 43.51 0.00e+00 820.00
IUUC-Csv-026051 Ciona savignyi 43.83 0.00e+00 809.00
IUUC-Dre-028130 Danio rerio 44.33 0.00e+00 872.00
IUUC-Dno-029069 Dasypus novemcinctus 79.64 0.00e+00 1212.00
IUUC-Ete-032698 Echinops telfairi 77.43 0.00e+00 799.00
IUUC-Eca-033728 Equus caballus 79.70 0.00e+00 1809.00
IUUC-Eeu-034707 Erinaceus europaeus 83.21 4.00e-143 502.00
IUUC-Fca-035974 Felis catus 81.62 0.00e+00 1761.00
IUUC-Fal-037073 Ficedula albicollis 52.44 0.00e+00 998.00
IUUC-Gmo-039607 Gadus morhua 47.19 2.00e-144 506.00
IUUC-Gga-040440 Gallus gallus 53.80 0.00e+00 999.00
IUUC-Gac-042234 Gasterosteus aculeatus 44.01 0.00e+00 772.00
IUUC-Ggo-044473 Gorilla gorilla 99.65 0.00e+00 1196.00
IUUC-Itr-049034 Ictidomys tridecemlineatus 75.02 0.00e+00 1655.00
IUUC-Lch-049489 Latimeria chalumnae 50.05 0.00e+00 920.00
IUUC-Loc-052793 Lepisosteus oculatus 52.45 0.00e+00 1021.00
IUUC-Laf-054246 Loxodonta africana 86.71 0.00e+00 807.00
IUUC-Mcc-054827 Macaca mulatta 92.78 0.00e+00 2104.00
IUUC-Meu-056344 Macropus eugenii 64.34 0.00e+00 924.00
IUUC-Mga-059830 Meleagris gallopavo 54.07 0.00e+00 994.00
IUUC-Mmr-061157 Microcebus murinus 82.93 0.00e+00 1777.00
IUUC-Mdo-062870 Monodelphis domestica 68.80 0.00e+00 1362.00
IUUC-Mmu-064101 Mus musculus 78.84 0.00e+00 1593.00
IUUC-Mpu-066432 Mustela putorius furo 84.48 0.00e+00 1701.00
IUUC-Mlu-068011 Myotis lucifugus 71.46 0.00e+00 1519.00
IUUC-Nle-069572 Nomascus leucogenys 90.85 0.00e+00 1998.00
IUUC-Opr-070235 Ochotona princeps 83.78 0.00e+00 1548.00
IUUC-Oan-073735 Ornithorhynchus anatinus 67.10 0.00e+00 1316.00
IUUC-Ocu-074669 Oryctolagus cuniculus 78.42 0.00e+00 1617.00
IUUC-Oga-089007 Otolemur garnettii 84.71 0.00e+00 1809.00
IUUC-Ptr-091286 Pan troglodytes 98.87 0.00e+00 2259.00
IUUC-Pan-091905 Papio anubis 93.57 0.00e+00 2104.00
IUUC-Psi-093555 Pelodiscus sinensis 54.52 0.00e+00 1082.00
IUUC-Pma-094736 Petromyzon marinus 35.98 0.00e+00 646.00
IUUC-Pfo-097081 Poecilia formosa 42.66 0.00e+00 754.00
IUUC-Pab-097893 Pongo abelii 95.86 0.00e+00 2173.00
IUUC-Rno-105786 Rattus norvegicus 79.87 0.00e+00 1573.00
IUUC-Sha-107399 Sarcophilus harrisii 67.60 0.00e+00 1340.00
IUUC-Tgu-116796 Taeniopygia guttata 54.68 0.00e+00 1025.00
IUUC-Tru-118592 Takifugu rubripes 41.52 0.00e+00 714.00
IUUC-Tni-120456 Tetraodon nigroviridis 40.07 0.00e+00 679.00
IUUC-Tbe-127411 Tupaia belangeri 81.02 2.00e-106 380.00
IUUC-Xtr-131990 Xenopus tropicalis 52.18 0.00e+00 1022.00
Created Date 25-Jun-2017

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