iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061871

Ensembl Protein ID

ENSMODP00000011633.3

UniProt Accession

F7GJZ7; F7GJZ7_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

CSK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000009310.3	ENSMODT00000011853.3	ENSMODP00000011633.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-10	40.7	13	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ y++ ++ + +L + kGdv++++   ++d +W k+ k+  g++G++P+n+v+k
   Q: 13   ECIAKYNFHGTAEQDLPFSKGDVLTIV-AVTKDPNWYKA-KNKVGREGIIPANYVQK 67
           68999**********************.***********.6**************87 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSAIQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKVGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTAATGGT ACCAAGTGAC GGAGCCTTCT TGTGAGAGTC GGACCTCAGA ACTCCAGAGA 60
AGATGTCGGC AATCCAGGTA CGGGCCTGGG GAGGGGGTGC AGGGAGGGGG CCGTGGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034332--P:adherens junction organization
GO:0030154--P:cell differentiation
GO:0007417--P:central nervous system development
GO:0045087--P:innate immune response
GO:0008285--P:negative regulation of cell proliferation
GO:0042997--P:negative regulation of Golgi to plasma membrane protein transport
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0001817--P:regulation of cytokine production
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mdo:100017323

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	93.56	0.00e+00	885.00
IUUC-Cin-025513	Ciona intestinalis	54.85	7.00e-146	510.00
IUUC-Csv-025899	Ciona savignyi	51.57	4.00e-138	484.00
IUUC-Fal-037215	Ficedula albicollis	94.89	0.00e+00	890.00
IUUC-Gmo-039103	Gadus morhua	85.10	0.00e+00	801.00
IUUC-Gga-040506	Gallus gallus	94.89	0.00e+00	888.00
IUUC-Loc-052586	Lepisosteus oculatus	88.22	0.00e+00	842.00
IUUC-Meu-056387	Macropus eugenii	98.22	0.00e+00	927.00
IUUC-Mga-060040	Meleagris gallopavo	93.50	0.00e+00	863.00
IUUC-Ont-072457	Oreochromis niloticus	84.20	0.00e+00	795.00
IUUC-Ola-087366	Oryzias latipes	84.12	0.00e+00	793.00
IUUC-Oga-087928	Otolemur garnettii	95.11	0.00e+00	897.00
IUUC-Pfo-096126	Poecilia formosa	83.52	0.00e+00	790.00
IUUC-Sha-106987	Sarcophilus harrisii	98.67	0.00e+00	928.00
IUUC-Tru-118712	Takifugu rubripes	82.46	0.00e+00	776.00
IUUC-Tni-119856	Tetraodon nigroviridis	82.62	0.00e+00	783.00
IUUC-Xtr-132763	Xenopus tropicalis	85.11	0.00e+00	801.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence