iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106987

Ensembl Protein ID

ENSSHAP00000018390.1

UniProt Accession

G3WSI5; G3WSI5_SARHA

Genbank Protein ID

ENSSHAP00000018390

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01001178

Gene Name

CSK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015608.1	ENSSHAT00000018542.1	ENSSHAP00000018390.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-10	40.7	13	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ y++ ++ + +L + kGdv++++   ++d +W k+ k+  g++G++P+n+v+k
   Q: 13   ECIAKYNFHGTAEQDLPFSKGDVLTIV-AVTKDPNWYKA-KNKVGREGIIPANYVQK 67
           68999**********************.***********.6**************87 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSAIQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTAATGGT ACCAAGTGAC GGATCCTTCT TGTGAGAGTT GGACGTCAGA ACTCAAGATG 60
TCGGCAATCC AGGTATGGAG GAGATGAGCT GGGGGAGGGA GAGCACGGGG CGGGGGGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0008285--P:negative regulation of cell proliferation
GO:0042997--P:negative regulation of Golgi to plasma membrane protein transport

KEGG

shr:100924855

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	94.00	0.00e+00	890.00
IUUC-Bra-017486	Brassica rapa	33.79	8.00e-22	99.00
IUUC-Cin-025513	Ciona intestinalis	54.85	5.00e-146	510.00
IUUC-Csv-025899	Ciona savignyi	51.57	2.00e-138	485.00
IUUC-Fal-037215	Ficedula albicollis	95.33	0.00e+00	895.00
IUUC-Gmo-039103	Gadus morhua	84.88	0.00e+00	801.00
IUUC-Gga-040506	Gallus gallus	95.33	0.00e+00	893.00
IUUC-Loc-052586	Lepisosteus oculatus	88.44	0.00e+00	845.00
IUUC-Meu-056387	Macropus eugenii	99.11	0.00e+00	931.00
IUUC-Mtr-058657	Medicago truncatula	27.89	1.00e-19	92.00
IUUC-Mga-060040	Meleagris gallopavo	93.95	0.00e+00	868.00
IUUC-Mdo-061871	Monodelphis domestica	98.67	0.00e+00	928.00
IUUC-Ont-072457	Oreochromis niloticus	84.42	0.00e+00	798.00
IUUC-Ola-087366	Oryzias latipes	84.56	0.00e+00	795.00
IUUC-Oga-087928	Otolemur garnettii	95.78	0.00e+00	902.00
IUUC-Pfo-096126	Poecilia formosa	83.75	0.00e+00	794.00
IUUC-Tru-118712	Takifugu rubripes	82.23	0.00e+00	776.00
IUUC-Tni-119856	Tetraodon nigroviridis	82.39	0.00e+00	782.00
IUUC-Xtr-132763	Xenopus tropicalis	85.56	0.00e+00	807.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence