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Tag Content
iUUCD ID IUUC-Mvi-060403
Ensembl Protein ID MVLG_06463T0
UniProt Accession U5HHD0; U5HHD0_USTV1
Genbank Protein ID KDE03033.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID AEIJ01000777
Gene Name PAC1; LIS1; MVLG_06463
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
MVLG_06463 MVLG_06463T0 MVLG_06463T0
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-47 155.4 109 147
UBD/Beta-Prp 5.20e-76 254.3 110 447
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++vt +af ++ +vs+s D tikvWD+ tg+ ++
   Q: 109 GHRSPVTRVAFhPSfSQVVSASEDSTIKVWDWETGDFER 147
    8***********88899******************9876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
    h s++t v+f+p+ s+++++s+d+tikvwd++tg++ r+++gh+++v++v+f+++g++lv++s+D t+kvwd + + k v tl gh++s+ s +f p
   Q: 110 HRSPVTRVAFHPSFSQVVSASEDSTIKVWDWETGDFERTIKGHTKAVQDVDFDSKGNFLVSCSSDLTLKVWDTNnDWKNVKTLYGHDHSISSARFLP 206
    6779999****************************************************************998578******************** PP
   S: 105 sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng......... 192
    ++d+++s+s+drtirvw++ +g c++ t+sgh ++v+++ ++dg+ l+s+s D+t r+Wd +tg+ ++l+g h++ ++ f +
   Q: 207 NDDFIISASRDRTIRVWEVASGFCVK-TFSGHADWVRSALPSSDGRQLISCSVDQTSRIWDAQTGETKTELRG-HDHVIEVAVFAPIAaypairela 301
    **************************.*********************************************9.*********88877788888888 PP
   S: 193 ..............kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav... 272
    + ++gs+d+t+klwd q+g+c++t+ gh+++v+ + f+p +++l+s+s+D++ir Wdl +g + ktl+ h + v++ a
   Q: 302 gltspkgadaktvgAFAATGSRDKTIKLWDTQSGQCLKTFVGHDNWVRALVFHPLGKFLLSASDDKTIRTWDLVTGRCSKTLEAHSHFVTCLAWgra 398
    88888889999999************************************************************************77777777555 PP
   S: 273 ..........lsfgdnvl........................vlgsedskvniw 292
    ++gs d++v++w
   Q: 399 papgssstatN-----GSttngmgkngtseasaetiqyvnvvATGSVDQSVKVW 447
    55544322221.....11334446666667777777777766888889999999 PP
   

Organism Microbotryum violaceum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MVSVLSERQK DELHKSMLDY LNTIGYTQTF AVLKEEANLA SFEIDPKAKH SGLLEKKWTS 60
VIRLQKKIME LETRNAQLQD ELSTAPSKRP SASSPDWLPR APARHSLAGH RSPVTRVAFH 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mvi-060403|E3,WD_repeat;UBD,Beta-Prp|Microbotryum violaceum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCCGTCGC GTCGGTCGCA CGGACACTCG CGAGCGTTGA GCGTTGAGCT CCTAAGCTCA 60
CCATCGAATC TAGTCCAACA ATCGCCGCTC TCGCCTGGTC GACATTGCCT CCGTCTCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mvi-060403|E3,WD_repeat;UBD,Beta-Prp|Microbotryum violaceum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 49.43 1.00e-124 437.00
IUUC-Apl-004024 Anas platyrhynchos 50.11 1.00e-129 454.00
IUUC-Aca-004564 Anolis carolinensis 49.89 3.00e-127 446.00
IUUC-Ago-007862 Ashbya gossypii 30.05 4.00e-41 160.00
IUUC-Acl-008360 Aspergillus clavatus 49.15 1.00e-122 431.00
IUUC-Afl-008502 Aspergillus flavus 48.78 2.00e-113 400.00
IUUC-Afu-008848 Aspergillus fumigatus 50.95 3.00e-130 456.00
IUUC-Ani-009173 Aspergillus nidulans 47.81 8.00e-112 395.00
IUUC-Ang-009873 Aspergillus niger 46.81 1.00e-113 401.00
IUUC-Aor-009973 Aspergillus oryzae 47.19 4.00e-111 392.00
IUUC-Ate-010523 Aspergillus terreus 45.18 1.00e-112 397.00
IUUC-Ame-011154 Astyanax mexicanus 50.56 8.00e-131 458.00
IUUC-Bgr-011972 Blumeria graminis 51.18 3.00e-130 456.00
IUUC-Bta-013106 Bos taurus 50.11 9.00e-130 454.00
IUUC-Bci-013615 Botrytis cinerea 50.53 3.00e-132 462.00
IUUC-Cel-018459 Caenorhabditis elegans 42.66 3.00e-107 380.00
IUUC-Cja-018755 Callithrix jacchus 48.54 3.00e-125 439.00
IUUC-Cfa-020749 Canis familiaris 50.11 9.00e-130 454.00
IUUC-Cpo-022371 Cavia porcellus 50.11 9.00e-130 454.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 37.46 2.00e-51 193.00
IUUC-Csa-023524 Chlorocebus sabaeus 48.81 1.00e-107 381.00
IUUC-Cho-024764 Choloepus hoffmanni 45.36 9.00e-101 358.00
IUUC-Cin-025753 Ciona intestinalis 53.85 1.00e-123 434.00
IUUC-Csv-025817 Ciona savignyi 53.08 2.00e-125 440.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 50.43 5.00e-125 439.00
IUUC-Cne-027087 Cryptococcus neoformans 60.92 6.00e-148 515.00
IUUC-Dre-028314 Danio rerio 49.44 8.00e-129 451.00
IUUC-Dno-029050 Dasypus novemcinctus 50.11 1.00e-129 454.00
IUUC-Dor-030222 Dipodomys ordii 46.29 4.00e-115 406.00
IUUC-Dse-031164 Dothistroma septosporum 49.36 9.00e-126 441.00
IUUC-Dme-031745 Drosophila melanogaster 47.20 2.00e-114 403.00
IUUC-Ete-032508 Echinops telfairi 42.92 2.00e-101 360.00
IUUC-Eca-034288 Equus caballus 48.97 2.00e-123 434.00
IUUC-Eeu-034984 Erinaceus europaeus 46.07 4.00e-114 402.00
IUUC-Fca-036498 Felis catus 50.11 9.00e-130 454.00
IUUC-Fal-036920 Ficedula albicollis 50.11 1.00e-129 454.00
IUUC-Fox-037996 Fusarium oxysporum 48.83 7.00e-122 429.00
IUUC-Fso-038160 Fusarium solani 47.00 1.00e-116 411.00
IUUC-Gmo-038983 Gadus morhua 50.45 7.00e-131 458.00
IUUC-Ggr-040051 Gaeumannomyces graminis 47.21 2.00e-118 417.00
IUUC-Gga-040623 Gallus gallus 50.11 1.00e-129 454.00
IUUC-Gac-041613 Gasterosteus aculeatus 50.23 1.00e-130 457.00
IUUC-Ggo-045410 Gorilla gorilla 45.22 2.00e-106 377.00
IUUC-Hsa-046358 Homo sapiens 50.11 9.00e-130 454.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 50.11 9.00e-130 454.00
IUUC-Kpa-049351 Komagataella pastoris 28.27 1.00e-39 155.00
IUUC-Lch-049936 Latimeria chalumnae 49.66 2.00e-129 454.00
IUUC-Loc-052476 Lepisosteus oculatus 49.20 3.00e-123 433.00
IUUC-Lma-053170 Leptosphaeria maculans 51.94 2.00e-128 450.00
IUUC-Laf-053713 Loxodonta africana 48.76 1.00e-125 441.00
IUUC-Mcc-054628 Macaca mulatta 49.89 1.00e-129 454.00
IUUC-Meu-055927 Macropus eugenii 42.12 7.00e-67 245.00
IUUC-Mor-056962 Magnaporthe oryzae 47.21 4.00e-119 419.00
IUUC-Mpo-057583 Magnaporthe poae 47.96 1.00e-114 404.00
IUUC-Mla-058819 Melampsora laricipopulina 59.30 3.00e-154 536.00
IUUC-Mga-059945 Meleagris gallopavo 50.34 5.00e-130 455.00
IUUC-Mmr-061289 Microcebus murinus 49.43 1.00e-124 438.00
IUUC-Mdo-061912 Monodelphis domestica 49.89 7.00e-129 451.00
IUUC-Mmu-063253 Mus musculus 50.11 9.00e-130 454.00
IUUC-Mpu-066638 Mustela putorius furo 50.11 9.00e-130 454.00
IUUC-Mlu-067267 Myotis lucifugus 48.88 6.00e-126 442.00
IUUC-Nfi-068571 Neosartorya fischeri 48.39 9.00e-119 418.00
IUUC-Ncr-068895 Neurospora crassa 52.52 4.00e-130 456.00
IUUC-Nle-069087 Nomascus leucogenys 51.76 2.00e-106 376.00
IUUC-Opr-070579 Ochotona princeps 50.11 1.00e-129 454.00
IUUC-Ont-072432 Oreochromis niloticus 50.45 6.00e-131 458.00
IUUC-Oan-073072 Ornithorhynchus anatinus 50.11 9.00e-130 454.00
IUUC-Ocu-074180 Oryctolagus cuniculus 50.11 1.00e-129 454.00
IUUC-Ola-086772 Oryzias latipes 50.45 8.00e-131 458.00
IUUC-Oga-088219 Otolemur garnettii 48.66 1.00e-125 441.00
IUUC-Oar-090394 Ovis aries 50.11 9.00e-130 454.00
IUUC-Ptr-091517 Pan troglodytes 50.11 9.00e-130 454.00
IUUC-Pan-092421 Papio anubis 49.89 1.00e-129 454.00
IUUC-Psi-093370 Pelodiscus sinensis 50.11 3.00e-129 453.00
IUUC-Pma-094319 Petromyzon marinus 48.56 3.00e-106 376.00
IUUC-Pno-094815 Phaeosphaeria nodorum 52.89 4.00e-134 469.00
IUUC-Pfo-097089 Poecilia formosa 50.68 9.00e-132 461.00
IUUC-Pab-098421 Pongo abelii 50.11 9.00e-130 454.00
IUUC-Pca-100120 Procavia capensis 43.71 2.00e-77 280.00
IUUC-Pva-102960 Pteropus vampyrus 49.89 2.00e-128 450.00
IUUC-Pgr-103538 Puccinia graminis 59.17 5.00e-157 545.00
IUUC-Ptt-103990 Puccinia triticina 49.80 9.00e-60 223.00
IUUC-Pte-104261 Pyrenophora teres 51.82 3.00e-132 462.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 52.35 1.00e-132 464.00
IUUC-Rno-105123 Rattus norvegicus 50.11 9.00e-130 454.00
IUUC-Sce-106208 Saccharomyces cerevisiae 30.85 2.00e-41 162.00
IUUC-Sha-107010 Sarcophilus harrisii 50.11 3.00e-129 452.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 34.55 8.00e-76 275.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 50.33 6.00e-130 455.00
IUUC-Sar-113309 Sorex araneus 48.74 3.00e-122 429.00
IUUC-Sre-115003 Sporisorium reilianum 65.62 1.00e-175 607.00
IUUC-Ssc-116148 Sus scrofa 50.11 9.00e-130 454.00
IUUC-Tgu-117299 Taeniopygia guttata 50.11 1.00e-129 454.00
IUUC-Tru-117721 Takifugu rubripes 49.77 7.00e-130 455.00
IUUC-Tsy-119493 Tarsius syrichta 50.11 9.00e-129 451.00
IUUC-Tni-120355 Tetraodon nigroviridis 50.00 4.00e-128 449.00
IUUC-Tre-121977 Trichoderma reesei 44.98 2.00e-113 401.00
IUUC-Tvi-122661 Trichoderma virens 47.56 3.00e-115 406.00
IUUC-Tme-127031 Tuber melanosporum 54.15 4.00e-133 466.00
IUUC-Tbe-127492 Tupaia belangeri 38.21 2.00e-65 241.00
IUUC-Ttr-128929 Tursiops truncatus 50.11 1.00e-129 454.00
IUUC-Uma-129347 Ustilago maydis 63.70 2.00e-175 607.00
IUUC-Vda-129837 Verticillium dahliae 50.54 2.00e-120 423.00
IUUC-Vpa-130532 Vicugna pacos 45.78 1.00e-100 357.00
IUUC-Xtr-131985 Xenopus tropicalis 50.11 4.00e-129 452.00
IUUC-Xma-133314 Xiphophorus maculatus 50.23 4.00e-131 459.00
IUUC-Yli-134403 Yarrowia lipolytica 38.78 7.00e-82 295.00
Created Date 25-Jun-2017

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