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Tag Content
UUCD2 ID IUUC-Fca-035605
UUCD1 version UUC-FeC-00612
Ensembl Protein ID ENSFCAP00000008141.3
UniProt Accession M3WA81; M3WA81_FELCA
Genbank Protein ID ENSFCAP00000008141
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AANG02113913
Gene Name ITCH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFCAG00000008780.3 ENSFCAT00000008782.3 ENSFCAP00000008141.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.50e-136 454.5 529 861
Active Site
Position(s) Description Evidence
830 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 529  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 616
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 617  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 702
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 703  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 790
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 791  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 861
           *********************************************************************96 PP
   
Organism Felis catus
Protein Sequence
(Fasta)
MSGSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIFETLKSNN MKLEEVVVTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Fca-035605|E3,HECT|Felis catus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGATATACA CTGGCGTTTG GAAATCACAG CTACAATCTT TAGCGGTTGG GGGAAGGAGG 60
GTGCTTTAAA AAAAAAAAAC AAACCCAAAA AACGCCTAGA GCGGTTGGGA GCAATCCCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Fca-035605|E3,HECT|Felis catus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination
KEGG fca:101086133
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002302 Ailuropoda melanoleuca 98.82 0.00e+00 1643.00
IUUC-Apl-003752 Anas platyrhynchos 84.08 0.00e+00 1458.00
IUUC-Aca-005338 Anolis carolinensis 82.20 0.00e+00 1445.00
IUUC-Ago-007742 Ashbya gossypii 48.71 5.00e-162 565.00
IUUC-Ame-011081 Astyanax mexicanus 88.81 0.00e+00 1098.00
IUUC-Bta-012782 Bos taurus 96.87 0.00e+00 1590.00
IUUC-Cja-018899 Callithrix jacchus 92.34 0.00e+00 1561.00
IUUC-Cfa-020648 Canis familiaris 97.65 0.00e+00 1608.00
IUUC-Cpo-022073 Cavia porcellus 96.87 0.00e+00 1639.00
IUUC-Csa-023252 Chlorocebus sabaeus 96.40 0.00e+00 1631.00
IUUC-Cho-024695 Choloepus hoffmanni 89.37 0.00e+00 1610.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 47.54 3.00e-155 542.00
IUUC-Cne-026849 Cryptococcus neoformans 47.47 1.00e-158 553.00
IUUC-Dre-028451 Danio rerio 75.97 0.00e+00 1309.00
IUUC-Dno-029884 Dasypus novemcinctus 96.17 0.00e+00 1659.00
IUUC-Eca-033793 Equus caballus 97.45 0.00e+00 1645.00
IUUC-Eeu-034716 Erinaceus europaeus 93.23 0.00e+00 890.00
IUUC-Fal-037126 Ficedula albicollis 84.13 0.00e+00 1458.00
IUUC-Fso-038393 Fusarium solani 46.87 5.00e-153 535.00
IUUC-Gmo-038596 Gadus morhua 80.96 0.00e+00 1009.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.86 2.00e-154 539.00
IUUC-Gga-040832 Gallus gallus 84.00 0.00e+00 1481.00
IUUC-Gac-041658 Gasterosteus aculeatus 86.99 0.00e+00 1126.00
IUUC-Ggo-044535 Gorilla gorilla 93.16 0.00e+00 1594.00
IUUC-Hsa-046564 Homo sapiens 92.58 0.00e+00 1620.00
IUUC-Itr-048918 Ictidomys tridecemlineatus 95.91 0.00e+00 1568.00
IUUC-Kpa-049273 Komagataella pastoris 49.05 3.00e-163 568.00
IUUC-Lch-050454 Latimeria chalumnae 92.64 0.00e+00 1169.00
IUUC-Loc-052647 Lepisosteus oculatus 75.14 0.00e+00 1363.00
IUUC-Laf-054383 Loxodonta africana 97.33 0.00e+00 1649.00
IUUC-Mcc-055532 Macaca mulatta 96.40 0.00e+00 1633.00
IUUC-Mor-057097 Magnaporthe oryzae 37.19 1.00e-155 543.00
IUUC-Mpo-057442 Magnaporthe poae 50.93 1.00e-143 504.00
IUUC-Mla-058996 Melampsora laricipopulina 51.66 3.00e-147 515.00
IUUC-Mga-059661 Meleagris gallopavo 84.00 0.00e+00 1469.00
IUUC-Mmr-061135 Microcebus murinus 96.87 0.00e+00 1665.00
IUUC-Mdo-062505 Monodelphis domestica 88.39 0.00e+00 1514.00
IUUC-Mmu-063375 Mus musculus 95.14 0.00e+00 1592.00
IUUC-Mpu-066203 Mustela putorius furo 98.94 0.00e+00 1645.00
IUUC-Mlu-067837 Myotis lucifugus 97.10 0.00e+00 1642.00
IUUC-Nle-069244 Nomascus leucogenys 95.37 0.00e+00 1612.00
IUUC-Opr-070585 Ochotona princeps 90.48 0.00e+00 1579.00
IUUC-Ont-071798 Oreochromis niloticus 88.10 0.00e+00 1142.00
IUUC-Oan-073679 Ornithorhynchus anatinus 66.46 0.00e+00 970.00
IUUC-Ocu-074298 Oryctolagus cuniculus 96.99 0.00e+00 1632.00
IUUC-Ola-086526 Oryzias latipes 85.74 0.00e+00 1124.00
IUUC-Oga-088167 Otolemur garnettii 90.18 0.00e+00 1516.00
IUUC-Oar-090316 Ovis aries 80.61 0.00e+00 1202.00
IUUC-Ptr-090819 Pan troglodytes 91.80 0.00e+00 1581.00
IUUC-Pan-092454 Papio anubis 96.40 0.00e+00 1633.00
IUUC-Psi-093319 Pelodiscus sinensis 82.83 0.00e+00 1438.00
IUUC-Pfo-097346 Poecilia formosa 84.84 0.00e+00 1108.00
IUUC-Pab-097580 Pongo abelii 85.83 0.00e+00 1461.00
IUUC-Pca-100923 Procavia capensis 79.35 0.00e+00 1367.00
IUUC-Pva-103209 Pteropus vampyrus 95.82 0.00e+00 1584.00
IUUC-Pgr-103620 Puccinia graminis 51.24 2.00e-145 509.00
IUUC-Rno-104924 Rattus norvegicus 94.79 0.00e+00 1601.00
IUUC-Sce-106289 Saccharomyces cerevisiae 48.97 1.00e-161 563.00
IUUC-Sha-107175 Sarcophilus harrisii 89.43 0.00e+00 1514.00
IUUC-Sja-107941 Schizosaccharomyces japonicus 49.04 1.00e-158 553.00
IUUC-Spo-108171 Schizosaccharomyces pombe 50.80 4.00e-162 565.00
IUUC-Sar-113761 Sorex araneus 86.46 0.00e+00 1489.00
IUUC-Tgu-116632 Taeniopygia guttata 80.12 0.00e+00 1335.00
IUUC-Tru-118442 Takifugu rubripes 89.10 0.00e+00 1123.00
IUUC-Tsy-119198 Tarsius syrichta 89.79 0.00e+00 1518.00
IUUC-Tni-120168 Tetraodon nigroviridis 86.70 0.00e+00 1058.00
IUUC-Tbe-127756 Tupaia belangeri 77.41 0.00e+00 1302.00
IUUC-Ttr-128504 Tursiops truncatus 90.96 0.00e+00 1192.00
IUUC-Vda-129753 Verticillium dahliae 46.77 3.00e-154 538.00
IUUC-Vpa-130103 Vicugna pacos 82.52 0.00e+00 1398.00
IUUC-Xtr-132885 Xenopus tropicalis 77.13 0.00e+00 1386.00
IUUC-Xma-133796 Xiphophorus maculatus 74.19 0.00e+00 1299.00
Created Date 25-Jun-2017

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