iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013222

Ensembl Protein ID

ENSBTAP00000043366.2

UniProt Accession

Q32LP7; SKAP2_BOVIN

Genbank Protein ID

AAI09481.1

Protein Name

Src kinase-associated phosphoprotein 2; Src family-associated phosphoprotein 2

Genbank Nucleotide ID

BC109480

Gene Name

SKAP2; SCAP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000005650.5	ENSBTAT00000046037.2	ENSBTAP00000043366.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.70e-12	45.8	301	354

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            q l+d +++ +deL++k+Gdv+++++ke +  gW++g  e +g  Gl+P+ +v +
   Q: 301  YQGLWDCTGALSDELSFKRGDVIYILSKEYNRYGWWVG--EMKGAIGLVPKAYVME 354
           57799999999***************************..9************987 PP

Organism

Bos taurus

Functional Description
(View)

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity).

Protein Sequence
(Fasta)

MPNPSSISAP YPLPEEIRNL LADVETFVAD ILRGENLSKK AKEKRDALVK KIKDVKSIYL 60
QESQDKGDAE DGEEYDDPFA GPPDTISLAS ERYDKDDEAP SDGNQFPPIA AQDLPFVLKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGTTATGA GCCTCGGCTT GGCAGTGTCC GGACTCTTAG CCCCGCTGTC CTTACCGGGA 60
TAGTCCGAGT CTAGATCGCA GCCGCAGCCC TAGCGGGTCG GTTCCCCTTT CAGCACAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0075--B-cell activation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005070--F:SH3/SH2 adaptor activity
GO:0042113--P:B cell activation
GO:0002757--P:immune response-activating signal transduction
GO:0008285--P:negative regulation of cell proliferation

KEGG

bta:616545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001212	Ailuropoda melanoleuca	91.36	0.00e+00	643.00
IUUC-Apl-003565	Anas platyrhynchos	71.15	4.00e-99	353.00
IUUC-Aca-005159	Anolis carolinensis	70.11	2.00e-123	434.00
IUUC-Ame-011510	Astyanax mexicanus	58.17	1.00e-105	376.00
IUUC-Cja-019091	Callithrix jacchus	86.39	0.00e+00	626.00
IUUC-Cfa-020492	Canis familiaris	91.09	2.00e-180	625.00
IUUC-Cpo-021974	Cavia porcellus	86.09	6.00e-163	566.00
IUUC-Csa-023195	Chlorocebus sabaeus	92.55	8.00e-129	452.00
IUUC-Cho-024462	Choloepus hoffmanni	81.67	1.00e-166	578.00
IUUC-Dre-027975	Danio rerio	49.09	7.00e-55	207.00
IUUC-Dno-029759	Dasypus novemcinctus	86.67	1.00e-177	615.00
IUUC-Dor-030116	Dipodomys ordii	78.49	1.00e-151	528.00
IUUC-Eca-034293	Equus caballus	90.25	1.00e-177	615.00
IUUC-Fca-036423	Felis catus	89.66	0.00e+00	629.00
IUUC-Fal-037146	Ficedula albicollis	72.32	6.00e-110	390.00
IUUC-Gmo-039059	Gadus morhua	56.72	4.00e-84	304.00
IUUC-Gga-040385	Gallus gallus	69.08	1.00e-112	399.00
IUUC-Gac-042122	Gasterosteus aculeatus	56.58	2.00e-92	332.00
IUUC-Ggo-044961	Gorilla gorilla	92.20	0.00e+00	644.00
IUUC-Hsa-046197	Homo sapiens	92.76	0.00e+00	646.00
IUUC-Lch-049485	Latimeria chalumnae	71.22	2.00e-109	388.00
IUUC-Loc-052335	Lepisosteus oculatus	61.89	2.00e-106	378.00
IUUC-Laf-053622	Loxodonta africana	89.75	1.00e-180	625.00
IUUC-Mcc-055725	Macaca mulatta	91.64	0.00e+00	641.00
IUUC-Meu-056098	Macropus eugenii	80.60	1.00e-156	545.00
IUUC-Mga-059932	Meleagris gallopavo	75.00	1.00e-108	385.00
IUUC-Mmr-061781	Microcebus murinus	86.63	4.00e-166	577.00
IUUC-Mdo-062502	Monodelphis domestica	75.49	9.00e-147	512.00
IUUC-Mmu-063978	Mus musculus	89.66	0.00e+00	628.00
IUUC-Mpu-065930	Mustela putorius furo	91.09	0.00e+00	637.00
IUUC-Mlu-067603	Myotis lucifugus	89.49	4.00e-115	407.00
IUUC-Nle-069223	Nomascus leucogenys	91.92	0.00e+00	639.00
IUUC-Opr-070422	Ochotona princeps	66.20	4.00e-115	407.00
IUUC-Ont-072351	Oreochromis niloticus	56.36	1.00e-103	369.00
IUUC-Oan-073125	Ornithorhynchus anatinus	85.99	2.00e-122	431.00
IUUC-Ocu-074410	Oryctolagus cuniculus	87.47	1.00e-165	575.00
IUUC-Ola-087314	Oryzias latipes	53.09	7.00e-89	320.00
IUUC-Oga-087912	Otolemur garnettii	90.81	0.00e+00	630.00
IUUC-Oar-089480	Ovis aries	98.04	0.00e+00	661.00
IUUC-Ptr-091579	Pan troglodytes	92.76	0.00e+00	646.00
IUUC-Pan-092200	Papio anubis	84.68	2.00e-163	568.00
IUUC-Psi-093510	Pelodiscus sinensis	74.51	1.00e-103	368.00
IUUC-Pfo-096925	Poecilia formosa	55.91	3.00e-98	351.00
IUUC-Pab-097723	Pongo abelii	91.64	0.00e+00	638.00
IUUC-Pca-100318	Procavia capensis	86.67	1.00e-178	618.00
IUUC-Pva-102860	Pteropus vampyrus	88.02	4.00e-179	620.00
IUUC-Rno-105825	Rattus norvegicus	86.59	2.00e-170	591.00
IUUC-Sha-107224	Sarcophilus harrisii	77.19	6.00e-130	456.00
IUUC-Sar-112982	Sorex araneus	79.46	4.00e-141	494.00
IUUC-Ssc-115926	Sus scrofa	91.64	0.00e+00	644.00
IUUC-Tgu-116935	Taeniopygia guttata	70.70	7.00e-103	366.00
IUUC-Tru-118152	Takifugu rubripes	48.68	4.00e-90	324.00
IUUC-Tsy-119643	Tarsius syrichta	83.84	6.00e-161	560.00
IUUC-Tni-120040	Tetraodon nigroviridis	56.02	6.00e-99	353.00
IUUC-Tbe-127242	Tupaia belangeri	87.74	3.00e-153	534.00
IUUC-Ttr-128482	Tursiops truncatus	82.17	4.00e-151	527.00
IUUC-Xtr-132597	Xenopus tropicalis	57.51	4.00e-98	350.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence