iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108062

UUCD1 version

UUC-ScP-00262

Ensembl Protein ID

SPAC11E3.04c.1:pep

UniProt Accession

O13685; UBC13_SCHPO

Genbank Protein ID

AAL79844.1; CAB11183.1

Protein Name

Ubiquitin-conjugating enzyme E2 13; E2 ubiquitin-conjugating enzyme 13; Ubiquitin carrier protein 13; Ubiquitin-protein ligase 13

Genbank Nucleotide ID

AF470232; CU329670

Gene Name

ubc13; spu13; SPAC11E3.04c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC11E3.04c	SPAC11E3.04c.1	SPAC11E3.04c.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-47	158.5	6	138

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           R+ ke+++l++dpp+gi+a p+++ +l  ++++++Gp+++ Yegg+F+le+ +p++YP+ PP+v+fltki+hPnv++ G++Cls lk  ++
   Q: 6    RIIKEIETLTRDPPPGIVAAPTED-NLRYFKITMEGPQQSAYEGGKFHLELFLPDEYPMMPPNVRFLTKIYHPNVDKLGRICLSTLK--KD 93
           899*********************.9************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkk 136
           Wspal++++vllsiq+l+  pnp++pl++++a+++k+n+ +   +
   Q: 94   WSPALQIRTVLLSIQALMGAPNPDDPLDNDVAKIWKENEPQAIAN 138
           **************************************9866555 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.

Protein Sequence
(Fasta)

MALPKRIIKE IETLTRDPPP GIVAAPTEDN LRYFKITMEG PQQSAYEGGK FHLELFLPDE 60
YPMMPPNVRF LTKIYHPNVD KLGRICLSTL KKDWSPALQI RTVLLSIQAL MGAPNPDDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAAGTACT TATTGTGTGT ACAGCATGCA TTCTAGGAAG TCCAAGTATA TGAACAATGG 60
CTTTGCCTAA GCGTATTATT AAGGTTTGCG CTTTCTGTTA GCATTTTTCA ACTAATAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0070914--P:UV-damage excision repair

KEGG

spo:SPAC11E3.04c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000100	Aegilops tauschii	68.97	1.00e-58	216.00
IUUC-Aml-001889	Ailuropoda melanoleuca	67.38	6.00e-54	200.00
IUUC-Atr-002818	Amborella trichopoda	68.97	7.00e-59	217.00
IUUC-Apl-003469	Anas platyrhynchos	67.13	3.00e-55	204.00
IUUC-Aca-005051	Anolis carolinensis	68.71	2.00e-57	212.00
IUUC-Aly-006258	Arabidopsis lyrata	68.28	2.00e-58	215.00
IUUC-Ath-007639	Arabidopsis thaliana	68.28	3.00e-58	214.00
IUUC-Ago-007837	Ashbya gossypii	76.23	3.00e-52	195.00
IUUC-Acl-008263	Aspergillus clavatus	69.59	8.00e-61	223.00
IUUC-Afl-008733	Aspergillus flavus	70.95	5.00e-62	227.00
IUUC-Afu-008946	Aspergillus fumigatus	69.59	8.00e-61	223.00
IUUC-Ani-009482	Aspergillus nidulans	68.03	4.00e-59	218.00
IUUC-Ang-009678	Aspergillus niger	70.95	9.00e-62	226.00
IUUC-Aor-010025	Aspergillus oryzae	70.95	5.00e-62	227.00
IUUC-Ate-010254	Aspergillus terreus	71.62	1.00e-62	229.00
IUUC-Ame-010742	Astyanax mexicanus	69.18	4.00e-57	211.00
IUUC-Bgr-012156	Blumeria graminis	64.00	5.00e-53	197.00
IUUC-Bta-012636	Bos taurus	68.71	2.00e-57	212.00
IUUC-Bci-013761	Botrytis cinerea	72.11	3.00e-61	224.00
IUUC-Bdi-014796	Brachypodium distachyon	68.28	3.00e-58	214.00
IUUC-Bol-016613	Brassica oleracea	67.59	5.00e-58	214.00
IUUC-Bra-017866	Brassica rapa	67.59	5.00e-58	214.00
IUUC-Cel-018119	Caenorhabditis elegans	65.52	4.00e-54	201.00
IUUC-Cja-019108	Callithrix jacchus	68.71	2.00e-57	212.00
IUUC-Cfa-021195	Canis familiaris	68.49	2.00e-56	209.00
IUUC-Cpo-022280	Cavia porcellus	66.67	3.00e-54	201.00
IUUC-Cre-022978	Chlamydomonas reinhardtii	71.03	2.00e-59	219.00
IUUC-Csa-023860	Chlorocebus sabaeus	63.95	8.00e-52	193.00
IUUC-Cho-024459	Choloepus hoffmanni	68.71	2.00e-57	212.00
IUUC-Cin-025278	Ciona intestinalis	68.49	5.00e-60	221.00
IUUC-Csv-025952	Ciona savignyi	64.19	1.00e-53	199.00
IUUC-Cgl-026752	Colletotrichum gloeosporioides	73.65	9.00e-63	229.00
IUUC-Cne-026809	Cryptococcus neoformans	75.57	4.00e-57	211.00
IUUC-Cme-027100	Cyanidioschyzon merolae	60.00	4.00e-50	187.00
IUUC-Dre-027814	Danio rerio	69.18	4.00e-57	211.00
IUUC-Dno-030059	Dasypus novemcinctus	68.03	1.00e-56	209.00
IUUC-Dor-030269	Dipodomys ordii	70.08	1.00e-49	186.00
IUUC-Dse-031505	Dothistroma septosporum	70.34	2.00e-60	221.00
IUUC-Dme-032097	Drosophila melanogaster	67.35	4.00e-58	214.00
IUUC-Ete-032369	Echinops telfairi	68.71	2.00e-57	212.00
IUUC-Eca-033230	Equus caballus	68.71	2.00e-57	212.00
IUUC-Fca-036161	Felis catus	66.44	8.00e-55	203.00
IUUC-Fal-036781	Ficedula albicollis	66.67	1.00e-55	206.00
IUUC-Fox-037840	Fusarium oxysporum	73.47	4.00e-62	227.00
IUUC-Fso-038118	Fusarium solani	73.47	4.00e-62	228.00
IUUC-Gmo-039561	Gadus morhua	67.81	6.00e-56	207.00
IUUC-Ggr-039807	Gaeumannomyces graminis	73.65	2.00e-62	229.00
IUUC-Gga-041024	Gallus gallus	68.71	2.00e-57	212.00
IUUC-Gac-042026	Gasterosteus aculeatus	66.67	8.00e-57	210.00
IUUC-Gma-043982	Glycine max	68.28	2.00e-58	215.00
IUUC-Ggo-044660	Gorilla gorilla	68.03	1.00e-56	209.00
IUUC-Hsa-045881	Homo sapiens	68.71	2.00e-57	212.00
IUUC-Hvu-047340	Hordeum vulgare	68.97	1.00e-58	216.00
IUUC-Itr-048778	Ictidomys tridecemlineatus	67.91	1.00e-50	189.00
IUUC-Kpa-049285	Komagataella pastoris	68.49	8.00e-59	216.00
IUUC-Lch-050548	Latimeria chalumnae	67.14	1.00e-53	199.00
IUUC-Lpe-051394	Leersia perrieri	67.59	6.00e-58	214.00
IUUC-Loc-052205	Lepisosteus oculatus	69.18	4.00e-57	211.00
IUUC-Lma-053056	Leptosphaeria maculans	72.11	9.00e-63	229.00
IUUC-Laf-053540	Loxodonta africana	68.35	9.00e-54	199.00
IUUC-Mcc-054863	Macaca mulatta	68.71	2.00e-57	212.00
IUUC-Meu-056482	Macropus eugenii	68.35	9.00e-54	199.00
IUUC-Mor-057014	Magnaporthe oryzae	71.62	2.00e-61	225.00
IUUC-Mpo-057586	Magnaporthe poae	73.65	1.00e-62	229.00
IUUC-Mtr-058552	Medicago truncatula	61.64	6.00e-55	204.00
IUUC-Mla-058920	Melampsora laricipopulina	67.12	1.00e-57	212.00
IUUC-Mga-059649	Meleagris gallopavo	65.75	3.00e-54	201.00
IUUC-Mvi-060483	Microbotryum violaceum	70.55	1.00e-59	219.00
IUUC-Mmr-061167	Microcebus murinus	68.71	2.00e-57	212.00
IUUC-Mdo-062701	Monodelphis domestica	68.71	2.00e-57	212.00
IUUC-Mmu-064070	Mus musculus	68.71	2.00e-57	212.00
IUUC-Mac-064742	Musa acuminata	68.28	2.00e-58	216.00
IUUC-Mpu-066401	Mustela putorius furo	68.71	3.00e-57	211.00
IUUC-Mlu-067229	Myotis lucifugus	67.36	1.00e-54	202.00
IUUC-Nfi-068526	Neosartorya fischeri	69.59	7.00e-61	223.00
IUUC-Ncr-068643	Neurospora crassa	72.97	2.00e-62	229.00
IUUC-Nle-070146	Nomascus leucogenys	68.71	2.00e-57	212.00
IUUC-Opr-070232	Ochotona princeps	75.24	7.00e-44	167.00
IUUC-Ont-071741	Oreochromis niloticus	68.49	2.00e-57	212.00
IUUC-Oan-073174	Ornithorhynchus anatinus	66.90	9.00e-55	203.00
IUUC-Ocu-074712	Oryctolagus cuniculus	68.71	2.00e-57	212.00
IUUC-Oba-075408	Oryza barthii	67.59	6.00e-58	214.00
IUUC-Obr-076881	Oryza brachyantha	67.59	6.00e-58	214.00
IUUC-Ogl-077242	Oryza glaberrima	67.59	6.00e-58	214.00
IUUC-Ogu-078465	Oryza glumaepatula	67.59	6.00e-58	214.00
IUUC-Oin-080035	Oryza indica	66.67	2.00e-54	201.00
IUUC-Olo-080555	Oryza longistaminata	67.59	6.00e-58	214.00
IUUC-Ome-081653	Oryza meridionalis	67.59	6.00e-58	214.00
IUUC-Oni-082400	Oryza nivara	67.59	6.00e-58	214.00
IUUC-Opu-083130	Oryza punctata	68.66	2.00e-53	200.00
IUUC-Oru-084649	Oryza rufipogon	67.59	6.00e-58	214.00
IUUC-Osa-085629	Oryza sativa	67.59	6.00e-58	214.00
IUUC-Ola-087083	Oryzias latipes	67.81	6.00e-56	207.00
IUUC-Olu-087886	Ostreococcus lucimarinus	63.70	7.00e-54	200.00
IUUC-Oga-088983	Otolemur garnettii	65.99	1.00e-54	202.00
IUUC-Oar-090440	Ovis aries	68.03	9.00e-57	210.00
IUUC-Ptr-090572	Pan troglodytes	68.71	2.00e-57	212.00
IUUC-Pan-092503	Papio anubis	67.35	1.00e-56	209.00
IUUC-Psi-093419	Pelodiscus sinensis	70.45	9.00e-53	196.00
IUUC-Pma-094609	Petromyzon marinus	44.90	4.00e-35	138.00
IUUC-Pno-094838	Phaeosphaeria nodorum	72.60	1.00e-62	229.00
IUUC-Ppa-095892	Physcomitrella patens	68.97	6.00e-59	217.00
IUUC-Pfo-096111	Poecilia formosa	68.49	3.00e-57	211.00
IUUC-Pab-097778	Pongo abelii	68.71	2.00e-57	212.00
IUUC-Pop-099707	Populus trichocarpa	68.28	4.00e-58	214.00
IUUC-Pca-100334	Procavia capensis	61.90	7.00e-51	190.00
IUUC-Ppe-101149	Prunus persica	68.28	2.00e-58	215.00
IUUC-Pva-102979	Pteropus vampyrus	68.71	2.00e-57	212.00
IUUC-Pgr-103654	Puccinia graminis	69.66	4.00e-58	214.00
IUUC-Ptt-103752	Puccinia triticina	66.67	1.00e-55	206.00
IUUC-Pte-104137	Pyrenophora teres	71.43	2.00e-62	228.00
IUUC-Pyt-104513	Pyrenophora triticirepentis	71.43	2.00e-62	228.00
IUUC-Rno-105927	Rattus norvegicus	68.71	2.00e-57	212.00
IUUC-Sce-106178	Saccharomyces cerevisiae	70.55	1.00e-58	216.00
IUUC-Sha-107493	Sarcophilus harrisii	68.71	2.00e-57	212.00
IUUC-Sja-107878	Schizosaccharomyces japonicus	89.86	6.00e-80	287.00
IUUC-Ssl-108395	Sclerotinia sclerotiorum	71.62	9.00e-62	226.00
IUUC-Smo-109587	Selaginella moellendorffii	67.12	3.00e-55	204.00
IUUC-Sit-110539	Setaria italica	69.66	4.00e-59	218.00
IUUC-Sly-110863	Solanum lycopersicum	68.28	3.00e-58	214.00
IUUC-Stu-112254	Solanum tuberosum	67.59	8.00e-58	213.00
IUUC-Sar-113464	Sorex araneus	68.35	9.00e-54	199.00
IUUC-Sbi-114864	Sorghum bicolor	68.97	9.00e-59	216.00
IUUC-Sre-114927	Sporisorium reilianum	69.39	5.00e-58	214.00
IUUC-Ssc-116096	Sus scrofa	68.71	2.00e-57	212.00
IUUC-Tgu-117266	Taeniopygia guttata	68.35	9.00e-54	199.00
IUUC-Tru-117903	Takifugu rubripes	68.49	5.00e-57	211.00
IUUC-Tsy-118952	Tarsius syrichta	68.35	9.00e-54	199.00
IUUC-Tni-120038	Tetraodon nigroviridis	68.49	5.00e-57	211.00
IUUC-Tca-121752	Theobroma cacao	69.40	1.00e-53	201.00
IUUC-Tre-121979	Trichoderma reesei	74.15	6.00e-62	227.00
IUUC-Tvi-122515	Trichoderma virens	74.15	1.00e-61	226.00
IUUC-Tae-124984	Triticum aestivum	68.28	3.00e-58	215.00
IUUC-Tur-126865	Triticum urartu	70.15	1.00e-54	203.00
IUUC-Tme-127129	Tuber melanosporum	72.79	2.00e-61	225.00
IUUC-Tbe-127846	Tupaia belangeri	68.35	9.00e-54	199.00
IUUC-Ttr-128808	Tursiops truncatus	66.67	5.00e-55	204.00
IUUC-Uma-129548	Ustilago maydis	69.39	7.00e-58	213.00
IUUC-Vda-129810	Verticillium dahliae	72.11	1.00e-61	226.00
IUUC-Vpa-130221	Vicugna pacos	63.70	2.00e-45	172.00
IUUC-Vvi-131158	Vitis vinifera	68.61	7.00e-54	200.00
IUUC-Xtr-132366	Xenopus tropicalis	67.11	3.00e-55	204.00
IUUC-Xma-133961	Xiphophorus maculatus	68.49	3.00e-57	211.00
IUUC-Yli-134605	Yarrowia lipolytica	71.92	1.00e-61	226.00
IUUC-Zma-135587	Zea mays	64.67	2.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence