iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	THPA	HPM
DNA & RNA Element
UTRdb	TRANSFAC	miRcode
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-17	65.1	373	398
UBD/Beta-Prp	3.60e-40	139.7	374	593

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf.sd.tllvsGsdDgtikvWD 29
           + c+++ +d ++lv+G++D  i++W+
   Q: 373  ILCFDYcPDrNFLVTGGYDAFIRLWN 398
           889999*******************9 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkl.lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            c ++ pd+++l+tg++d+ i++w+ +  k  ++ ++gh+  vt +  +++ + il+++s+D++i+vwd+ ++ c++               
   Q: 374  LCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRpVWLMKGHQTSVTHILVDSRNNsILISVSKDKNIRVWDMLDYICLQ--------------- 450
           23555566666666666666666665555553444466666666665555555566666666666666666666666............... PP
   S: 104  psgdklvsGshdrtirvwdletgqclee...............................................tlsghdgvvncvvvhpd 148
                                      +                                                ++ ++ +  c+v+ ++
   Q: 451  ---------------------------SfcgkffalgncpitsayffekdntlicstysigilkgyleaqglikaRKRTTHCSPLCAVLYSK 515
           ...........................44444444444444444444444444444444444444444445444466667777778888888 PP
   S: 149  g.nllvsGslDrtvrlWdlktgkllrtl..tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
             + +vsG+l +tv +W + tg+   ++  +gg++   + +++d++ ++l++g +dgt k+w++  g+c+ t+   ++
   Q: 516  IfKQVVSGCLRGTVSVWEVVTGRKTMEFavSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQ 593
           88********************99999999999*************************************99987665 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSSEDLAEIP QLQKLSIPHG FQNKEAASSP TPSITLSQVP DLQPGSQLFT EIHLAKIEKM 60
FEEDINSTGA LGMDAFIKAM KKVLSSVSDE MLKELFLKVD SDCEGFVTWQ KYVDYMMREF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGTTGAGA TGGGAGTTGG AAAGTGTTAG CACTTTGCCA GACTTTGCCA GCAAGATTAA 60
CTGAGGAGAT CAAATTGAGT CAGGGTGAGT GAGGGTTTTA GGTGAAAGTT GCTCTCCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50222--EF_HAND_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005509--F:calcium ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-020006	Callithrix jacchus	87.38	0.00e+00	1378.00
IUUC-Cfa-020765	Canis familiaris	68.55	0.00e+00	1619.00
IUUC-Cin-025265	Ciona intestinalis	27.01	7.00e-71	262.00
IUUC-Dre-027573	Danio rerio	27.17	2.00e-60	227.00
IUUC-Dno-029238	Dasypus novemcinctus	62.13	0.00e+00	1559.00
IUUC-Dme-031984	Drosophila melanogaster	22.84	7.00e-53	202.00
IUUC-Ggo-044932	Gorilla gorilla	96.51	0.00e+00	2484.00
IUUC-Lch-050281	Latimeria chalumnae	39.89	5.00e-157	548.00
IUUC-Loc-052029	Lepisosteus oculatus	41.97	3.00e-155	542.00
IUUC-Laf-054508	Loxodonta africana	74.66	0.00e+00	695.00
IUUC-Mcc-054635	Macaca mulatta	91.85	0.00e+00	2381.00
IUUC-Mmr-061370	Microcebus murinus	68.09	0.00e+00	1625.00
IUUC-Mdo-061862	Monodelphis domestica	48.57	0.00e+00	1095.00
IUUC-Mmu-063271	Mus musculus	75.87	1.00e-164	572.00
IUUC-Mpu-066224	Mustela putorius furo	64.89	0.00e+00	1597.00
IUUC-Ont-072106	Oreochromis niloticus	25.78	1.00e-49	191.00
IUUC-Ocu-074664	Oryctolagus cuniculus	73.39	0.00e+00	1447.00
IUUC-Oar-089288	Ovis aries	66.83	0.00e+00	1639.00
IUUC-Psi-093985	Pelodiscus sinensis	43.44	6.00e-135	474.00
IUUC-Pfo-097353	Poecilia formosa	25.56	4.00e-54	206.00
IUUC-Smo-108683	Selaginella moellendorffii	24.33	7.00e-41	163.00
IUUC-Ssc-115233	Sus scrofa	77.83	1.00e-77	282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence