iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107620

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01120803

Gene Name

USP48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017182.1	ENSSHAT00000020418.1	ENSSHAP00000020258.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-73	247.0	47	377
ULD/UDP/UBQ/UBQ_Other	4.90e-10	39.3	926	983

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp........kepkgellkslqklfeelwkskkkavsprel 73
           +Gl+Nlg+tCY+N  LQ+ +   elr++l                             + + ++++++lq lf+ l++s++++++p+ +
   Q: 47   VGLTNLGATCYVNTFLQVWFLNLELRQALYLcpstcgdhM---------MgdgiqeerDYEPQTICEHLQYLFALLQNSNRRYIDPSGF 126
           6*****************************9555555532.........33333333378888************************** PP
   S: 74   lkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnv 162
           +kal+     +++ +qqDaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c++c+++
   Q: 127  VKALG-----LDTGQQQDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRE 187
           ****9.....78899*******************.......................457889999*********************** PP
   S: 163  ssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
           s+  ++f++l+l+++g++     +l+dc+ +f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n+
   Q: 188  SKLLSKFYELELNIQGHK-----QLTDCITEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNT 271
           ******************.....9***************************************************************** PP
   S: 252  kvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg........... 327
           ++ f + Ld++p+++++e      + YeL+av++H G s+ sGHY+a+vk+ + + W++f+D+++++++ ++ +   +           
   Q: 272  YIGFSELLDMEPYMEHKEG----IYVYELSAVLIHRGvSAYSGHYIAHVKDPQTGeWYKFNDEEIEKMEGKKLQLGIEedlaepsksqt 356
           *****99*******99553....89**************************55555************9999998665999******** PP
   S: 328  ............staYvlfYk 336
                       ++aY+l+Y+
   Q: 357  rkpkcgkgthcsRNAYMLVYR 377
           ********************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 16   k...vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihl 69
           k   v+   t +eLK +i +++++ p +q+L ++GkiL +d  tL+ +g+ ++s+i+l
   Q: 926  KallVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILnDDTATLGTLGVIPESVILL 983
           344489999***********************************************98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LCRRNCKGNP NCLVGIGEHV WLGEIDENSF HNIDDPNCER RKKNSFVGLT NLGATCYVNT 60
FLQVWFLNLE LRQALYLCPS TCGDHMMGDG IQEERDYEPQ TICEHLQYLF ALLQNSNRRY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGTAGAA GAAATTGCAA AGGGAATCCG AATTGCTTGG TTGGCATCGG AGAACACGTC 60
TGGTTAGGGG AAATTGATGA AAACAGCTTT CACAACATTG ATGATCCCAA CTGTGAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	31.99	3.00e-76	280.00
IUUC-Aml-001357	Ailuropoda melanoleuca	90.34	0.00e+00	1826.00
IUUC-Atr-002976	Amborella trichopoda	31.69	2.00e-75	277.00
IUUC-Apl-003773	Anas platyrhynchos	85.64	0.00e+00	1657.00
IUUC-Aca-004466	Anolis carolinensis	82.05	0.00e+00	872.00
IUUC-Aly-006249	Arabidopsis lyrata	29.44	8.00e-69	255.00
IUUC-Ath-006700	Arabidopsis thaliana	30.25	3.00e-78	286.00
IUUC-Ame-011554	Astyanax mexicanus	66.06	0.00e+00	1330.00
IUUC-Bta-012573	Bos taurus	89.37	0.00e+00	1830.00
IUUC-Bdi-014149	Brachypodium distachyon	32.23	2.00e-78	287.00
IUUC-Bol-016289	Brassica oleracea	32.13	9.00e-78	285.00
IUUC-Bra-017494	Brassica rapa	32.35	9.00e-82	298.00
IUUC-Cel-018662	Caenorhabditis elegans	27.94	5.00e-28	120.00
IUUC-Cja-019991	Callithrix jacchus	89.86	0.00e+00	1839.00
IUUC-Cfa-020294	Canis familiaris	90.26	0.00e+00	1864.00
IUUC-Cpo-021706	Cavia porcellus	87.57	0.00e+00	1803.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	36.48	5.00e-42	167.00
IUUC-Csa-023931	Chlorocebus sabaeus	89.67	0.00e+00	1840.00
IUUC-Cho-024566	Choloepus hoffmanni	82.47	9.00e-140	491.00
IUUC-Cin-025307	Ciona intestinalis	49.81	1.00e-69	256.00
IUUC-Csv-026006	Ciona savignyi	35.87	6.00e-136	478.00
IUUC-Cne-027065	Cryptococcus neoformans	27.63	5.00e-65	243.00
IUUC-Dre-027624	Danio rerio	66.83	0.00e+00	1367.00
IUUC-Dno-029633	Dasypus novemcinctus	91.32	0.00e+00	1266.00
IUUC-Dor-030809	Dipodomys ordii	69.46	0.00e+00	1070.00
IUUC-Ete-032818	Echinops telfairi	89.48	0.00e+00	935.00
IUUC-Eca-033692	Equus caballus	90.35	0.00e+00	1850.00
IUUC-Eeu-035185	Erinaceus europaeus	65.33	0.00e+00	679.00
IUUC-Fca-035676	Felis catus	89.57	0.00e+00	1852.00
IUUC-Fal-036913	Ficedula albicollis	84.84	0.00e+00	1717.00
IUUC-Gmo-038532	Gadus morhua	63.14	0.00e+00	1287.00
IUUC-Gga-041041	Gallus gallus	85.04	0.00e+00	1714.00
IUUC-Gac-042570	Gasterosteus aculeatus	63.67	0.00e+00	1311.00
IUUC-Gma-044136	Glycine max	27.38	7.00e-91	328.00
IUUC-Ggo-045367	Gorilla gorilla	84.97	0.00e+00	1706.00
IUUC-Hsa-046019	Homo sapiens	89.57	0.00e+00	1840.00
IUUC-Hvu-047303	Hordeum vulgare	33.01	3.00e-62	233.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	87.54	0.00e+00	1818.00
IUUC-Lch-049989	Latimeria chalumnae	73.90	0.00e+00	1532.00
IUUC-Lpe-051612	Leersia perrieri	32.08	4.00e-76	279.00
IUUC-Loc-052756	Lepisosteus oculatus	68.21	0.00e+00	1423.00
IUUC-Laf-054043	Loxodonta africana	88.78	0.00e+00	1837.00
IUUC-Mcc-054986	Macaca mulatta	89.87	0.00e+00	1841.00
IUUC-Meu-056228	Macropus eugenii	96.81	0.00e+00	702.00
IUUC-Mtr-058762	Medicago truncatula	29.59	3.00e-84	306.00
IUUC-Mga-059896	Meleagris gallopavo	84.44	0.00e+00	1696.00
IUUC-Mvi-060269	Microbotryum violaceum	36.75	2.00e-61	231.00
IUUC-Mmr-060887	Microcebus murinus	89.96	0.00e+00	1839.00
IUUC-Mdo-062506	Monodelphis domestica	94.78	0.00e+00	1921.00
IUUC-Mmu-063642	Mus musculus	85.11	0.00e+00	1769.00
IUUC-Mac-064896	Musa acuminata	31.10	7.00e-76	278.00
IUUC-Mpu-066194	Mustela putorius furo	90.06	0.00e+00	1840.00
IUUC-Mlu-067233	Myotis lucifugus	89.64	0.00e+00	1844.00
IUUC-Nle-069052	Nomascus leucogenys	89.96	0.00e+00	1842.00
IUUC-Opr-070890	Ochotona princeps	91.33	0.00e+00	1123.00
IUUC-Ont-071450	Oreochromis niloticus	62.60	0.00e+00	1263.00
IUUC-Oan-073252	Ornithorhynchus anatinus	86.99	0.00e+00	1018.00
IUUC-Ocu-073796	Oryctolagus cuniculus	88.61	0.00e+00	1647.00
IUUC-Oba-075563	Oryza barthii	34.38	2.00e-78	287.00
IUUC-Obr-076394	Oryza brachyantha	32.36	1.00e-78	288.00
IUUC-Ogl-077339	Oryza glaberrima	39.93	3.00e-39	155.00
IUUC-Ogu-079007	Oryza glumaepatula	33.99	8.00e-73	268.00
IUUC-Oin-079997	Oryza indica	34.38	1.00e-78	288.00
IUUC-Olo-080364	Oryza longistaminata	34.38	1.00e-78	288.00
IUUC-Ome-081165	Oryza meridionalis	33.16	5.00e-73	269.00
IUUC-Oni-083026	Oryza nivara	34.38	9.00e-79	288.00
IUUC-Opu-083284	Oryza punctata	34.85	7.00e-73	268.00
IUUC-Oru-084797	Oryza rufipogon	34.38	1.00e-78	288.00
IUUC-Osa-086221	Oryza sativa	39.93	3.00e-39	155.00
IUUC-Ola-086568	Oryzias latipes	64.33	0.00e+00	1319.00
IUUC-Oga-088687	Otolemur garnettii	89.67	0.00e+00	1832.00
IUUC-Oar-090345	Ovis aries	89.94	0.00e+00	1830.00
IUUC-Ptr-090734	Pan troglodytes	89.67	0.00e+00	1840.00
IUUC-Pan-091704	Papio anubis	86.43	0.00e+00	1748.00
IUUC-Psi-092937	Pelodiscus sinensis	85.85	0.00e+00	1583.00
IUUC-Ppa-095808	Physcomitrella patens	28.27	4.00e-69	256.00
IUUC-Pab-098129	Pongo abelii	89.67	0.00e+00	1841.00
IUUC-Pop-099738	Populus trichocarpa	31.86	7.00e-76	278.00
IUUC-Pca-100647	Procavia capensis	95.83	1.00e-169	590.00
IUUC-Ppe-102091	Prunus persica	32.15	3.00e-80	293.00
IUUC-Pva-102719	Pteropus vampyrus	89.27	0.00e+00	1823.00
IUUC-Rno-105363	Rattus norvegicus	86.52	0.00e+00	1790.00
IUUC-Smo-109487	Selaginella moellendorffii	27.04	2.00e-79	291.00
IUUC-Sit-110683	Setaria italica	31.60	2.00e-76	280.00
IUUC-Sly-111377	Solanum lycopersicum	32.10	3.00e-79	290.00
IUUC-Stu-111969	Solanum tuberosum	32.25	5.00e-69	255.00
IUUC-Sar-113099	Sorex araneus	88.70	0.00e+00	1625.00
IUUC-Sbi-113833	Sorghum bicolor	41.81	2.00e-56	211.00
IUUC-Ssc-115279	Sus scrofa	82.96	0.00e+00	1242.00
IUUC-Tgu-117519	Taeniopygia guttata	82.19	0.00e+00	1641.00
IUUC-Tru-117651	Takifugu rubripes	63.76	0.00e+00	1296.00
IUUC-Tsy-119201	Tarsius syrichta	87.36	0.00e+00	1720.00
IUUC-Tni-120840	Tetraodon nigroviridis	64.89	0.00e+00	1318.00
IUUC-Tca-121674	Theobroma cacao	30.99	1.00e-84	308.00
IUUC-Tae-125814	Triticum aestivum	32.41	3.00e-76	280.00
IUUC-Tur-126599	Triticum urartu	32.35	1.00e-75	278.00
IUUC-Tbe-127782	Tupaia belangeri	84.67	0.00e+00	1054.00
IUUC-Ttr-128312	Tursiops truncatus	88.58	0.00e+00	1807.00
IUUC-Vpa-130348	Vicugna pacos	89.63	0.00e+00	1827.00
IUUC-Vvi-131353	Vitis vinifera	32.11	5.00e-82	299.00
IUUC-Xtr-132172	Xenopus tropicalis	67.65	0.00e+00	1282.00
IUUC-Xma-133263	Xiphophorus maculatus	65.18	0.00e+00	1288.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence