iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052240

Ensembl Protein ID

ENSLOCP00000013024.1

UniProt Accession

W5MXB5; W5MXB5_LEPOC

Genbank Protein ID

ENSLOCP00000013024

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01000185

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000010634.1	ENSLOCT00000013052.1	ENSLOCP00000013024.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-27	93.8	304	342
E3 adaptor/Cullin RING/APC_C/CDC20	7.60e-146	485.3	169	471
UBD/Beta-Prp	2.50e-41	141.9	223	469

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH  +v++l++ +d  +l+sG++D+++ vW+ ++ v+++
   Q: 304  GHRQEVCGLKWsPDhQHLASGGNDNKLLVWNSSSLVPVQ 342
           8***********999****************88888776 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+kvldapel+ddfylnL+dWs+ nvl+v+Lg++vylwsa+t++v++l+dl  ++d+vtsv w e+g+l+avGt+kg v+i+D+++ kk
   Q: 169  PFKVLDAPELQDDFYLNLVDWSAGNVLSVGLGACVYLWSACTSQVTRLCDLsVDGDSVTSVCWNERGSLVAVGTHKGYVQIWDAAAGKK 257
           689************************************************999*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfke 177
           +  l+ghsarvgaL+Wnae+lssGsrd+ il+rdvr++ +  ++lq+h+qevCGlkw+ d+++LasGGnDn++ vw++ss  P++++++
   Q: 258  LICLDGHSARVGALAWNAEQLSSGSRDRLILQRDVRCPAQAERRLQGHRQEVCGLKWSPDHQHLASGGNDNKLLVWNSSSLVPVQQYTD 346
           ***************************************************************************************** PP
   S: 178  hkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgh 266
           h aavkaiawsP+q++lLasGGGtaDrci+fwntltg+ l++ dtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+gh
   Q: 347  HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQSTDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 435
           ***************************************************************************************** PP
   S: 267  eaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           ++Rvl+la+spdgeaivt+agDetlrfw++f+k++ 
   Q: 436  SYRVLYLAISPDGEAIVTGAGDETLRFWNVFSKTRC 471
           ********************************9875 PP

UBD/Beta-Prp

   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsv 97
            + +t+v++ + +sl+a+g   g +++wd+  gk+l +l gh+a v a+ ++ ++  l +gs+Dr+i   d++   +  + l+gh ++v
   Q: 223  GDSVTSVCWNERGSLVAVGTHKGYVQIWDAAAGKKLICLDGHSARVGALAWNAEQ--LSSGSRDRLILQRDVRcPAQAERRLQGHRQEV 309
           567899************************************************6..**********9989995556668999****** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsG..slDrtvrlWdlktgkllrtltgghtdsv 183
           + l++sp+ ++l+sG++d+ + vw+ ++   ++   + h ++v  ++++p +  ll+sG  ++Dr++r+W+  tg+ l+       ++v
   Q: 310  CGLKWSPDHQHLASGGNDNKLLVWNSSSLVPVQ-QYTDHLAAVKAIAWSPHQhGLLASGggTADRCIRFWNTLTGQPLQSTD--TGSQV 395
           *********************************.9*****************9*****73369****************994..589** PP
   S: 184  yslsfdsngkelvs..gsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
             l++++  +elvs  g   +++ +w + + + v +l+gh+  v+ ++ sp++e +v+g+ D+++r+W++ s++
   Q: 396  CNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAISPDGEAIVTGAGDETLRFWNVFSKT 469
           *************967889*************************************************986654 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MDQDYERRLL RQINHPNRPE RPLAPSAAVN CTTSVLKSGD RFIPARAGCN WTVNFHSINE 60
NSKSPNQNRK AKEASSDSGK DAVAYAALLR NELLGASIEK VSDPHTEDRR FTQPAQDTHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCGGCCCA GAGGGATACG TGTGACTGGG AGAAGAGGAG ACGGAGAAGG GAGCCGGACT 60
GGAGAGTGAG AAGAGGGCGA GACGAGAGTG ACAGGCGTGC CAGAAAGGGC GAGACGCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011773	Astyanax mexicanus	86.01	0.00e+00	868.00
IUUC-Dre-027860	Danio rerio	86.65	0.00e+00	870.00
IUUC-Fox-037814	Fusarium oxysporum	64.80	1.00e-124	439.00
IUUC-Gmo-039431	Gadus morhua	80.94	0.00e+00	810.00
IUUC-Gac-041566	Gasterosteus aculeatus	85.42	0.00e+00	826.00
IUUC-Ont-071725	Oreochromis niloticus	86.65	0.00e+00	875.00
IUUC-Ola-086983	Oryzias latipes	85.16	0.00e+00	861.00
IUUC-Pfo-096991	Poecilia formosa	86.65	0.00e+00	837.00
IUUC-Tru-118528	Takifugu rubripes	84.18	0.00e+00	818.00
IUUC-Tni-120312	Tetraodon nigroviridis	84.84	0.00e+00	813.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence