iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020511

Ensembl Protein ID

ENSCAFP00000032817.2

UniProt Accession

F1PSI2; F1PSI2_CANLF

Genbank Protein ID

ENSCAFP00000032817

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03013880

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007122.3	ENSCAFT00000037329.2	ENSCAFP00000032817.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-16	59.7	183	238

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 183  IVIALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLTTRKEGYIPSNYVARVD 238
           689************************...99*************************97 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MRVHAVGSES SGAGLGYTGV GLASLRARLR SPDGLWVPPS PRSQPERTAE AEASRRGRRG 60
FSARGAREAA RRPSPSEAAL CLFSKVSPSP FGCGRPGSPG AAELGGRSSC EDPGCPQEEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGAGTCC ACGCTGTGGG GTCAGAGTCT TCAGGGGCGG GGTTAGGATA CACGGGGGTG 60
GGGTTAGCAT CGCTCAGGGC GCGGCTAAGG AGCCCAGATG GCCTGTGGGT GCCACCGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cfa:485828

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	93.73	0.00e+00	1024.00
IUUC-Apl-003285	Anas platyrhynchos	80.08	0.00e+00	830.00
IUUC-Aca-004724	Anolis carolinensis	79.37	0.00e+00	804.00
IUUC-Ame-011954	Astyanax mexicanus	75.49	0.00e+00	768.00
IUUC-Bta-013060	Bos taurus	93.32	0.00e+00	1028.00
IUUC-Bdi-014122	Brachypodium distachyon	31.78	2.00e-21	97.40
IUUC-Cja-019817	Callithrix jacchus	90.51	0.00e+00	941.00
IUUC-Cpo-022538	Cavia porcellus	89.90	0.00e+00	947.00
IUUC-Csa-024143	Chlorocebus sabaeus	91.88	0.00e+00	962.00
IUUC-Dre-028157	Danio rerio	76.68	0.00e+00	797.00
IUUC-Dno-029761	Dasypus novemcinctus	89.29	0.00e+00	943.00
IUUC-Eca-034090	Equus caballus	92.18	0.00e+00	1004.00
IUUC-Fca-035937	Felis catus	90.70	0.00e+00	970.00
IUUC-Fal-036624	Ficedula albicollis	77.95	0.00e+00	808.00
IUUC-Gmo-039009	Gadus morhua	72.37	0.00e+00	755.00
IUUC-Gga-040296	Gallus gallus	75.35	0.00e+00	787.00
IUUC-Gac-042362	Gasterosteus aculeatus	74.56	0.00e+00	780.00
IUUC-Ggo-044570	Gorilla gorilla	91.25	0.00e+00	991.00
IUUC-Hsa-046378	Homo sapiens	91.44	0.00e+00	999.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	86.67	0.00e+00	942.00
IUUC-Loc-052904	Lepisosteus oculatus	77.95	0.00e+00	816.00
IUUC-Laf-053654	Loxodonta africana	90.14	0.00e+00	952.00
IUUC-Mcc-055317	Macaca mulatta	91.87	0.00e+00	964.00
IUUC-Mga-060194	Meleagris gallopavo	81.29	0.00e+00	768.00
IUUC-Mmr-061510	Microcebus murinus	88.49	0.00e+00	934.00
IUUC-Mdo-062035	Monodelphis domestica	83.96	0.00e+00	895.00
IUUC-Mmu-064037	Mus musculus	88.74	0.00e+00	985.00
IUUC-Mpu-066874	Mustela putorius furo	95.24	0.00e+00	1006.00
IUUC-Mlu-068202	Myotis lucifugus	90.08	0.00e+00	929.00
IUUC-Nle-069222	Nomascus leucogenys	91.67	0.00e+00	959.00
IUUC-Opr-070705	Ochotona princeps	85.90	0.00e+00	958.00
IUUC-Ont-072347	Oreochromis niloticus	82.06	0.00e+00	764.00
IUUC-Ocu-074490	Oryctolagus cuniculus	87.67	0.00e+00	929.00
IUUC-Oba-075219	Oryza barthii	31.72	7.00e-22	99.40
IUUC-Ogu-078206	Oryza glumaepatula	31.72	7.00e-22	99.40
IUUC-Oin-079439	Oryza indica	31.72	5.00e-22	99.80
IUUC-Olo-080886	Oryza longistaminata	31.72	7.00e-22	99.00
IUUC-Oni-082350	Oryza nivara	29.82	9.00e-22	99.00
IUUC-Opu-083900	Oryza punctata	31.72	2.00e-22	101.00
IUUC-Oru-085212	Oryza rufipogon	29.82	1.00e-21	98.60
IUUC-Ola-086521	Oryzias latipes	81.39	0.00e+00	777.00
IUUC-Oga-088153	Otolemur garnettii	90.10	0.00e+00	947.00
IUUC-Oar-090184	Ovis aries	91.14	0.00e+00	986.00
IUUC-Ptr-090505	Pan troglodytes	87.64	0.00e+00	939.00
IUUC-Pan-092260	Papio anubis	92.06	0.00e+00	966.00
IUUC-Pma-094311	Petromyzon marinus	74.72	0.00e+00	735.00
IUUC-Pfo-096566	Poecilia formosa	75.74	0.00e+00	795.00
IUUC-Pva-103021	Pteropus vampyrus	94.64	0.00e+00	998.00
IUUC-Rno-105309	Rattus norvegicus	88.27	0.00e+00	937.00
IUUC-Sha-107099	Sarcophilus harrisii	83.30	0.00e+00	887.00
IUUC-Sit-110451	Setaria italica	33.33	1.00e-22	102.00
IUUC-Sly-111528	Solanum lycopersicum	32.27	1.00e-22	102.00
IUUC-Stu-112831	Solanum tuberosum	31.82	8.00e-22	99.40
IUUC-Sbi-114009	Sorghum bicolor	33.80	2.00e-22	100.00
IUUC-Tgu-116912	Taeniopygia guttata	78.30	0.00e+00	804.00
IUUC-Tru-118449	Takifugu rubripes	80.36	0.00e+00	761.00
IUUC-Tae-123706	Triticum aestivum	32.31	7.00e-22	99.40
IUUC-Tur-126022	Triticum urartu	32.31	7.00e-22	99.40
IUUC-Tbe-128144	Tupaia belangeri	76.62	0.00e+00	813.00
IUUC-Xma-133902	Xiphophorus maculatus	75.45	0.00e+00	791.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence