iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054257

Ensembl Protein ID

ENSLAFP00000022132.1

UniProt Accession

G3U2S4; G3U2S4_LOXAF

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000025559.1	ENSLAFT00000030798.1	ENSLAFP00000022132.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.61	2.00e-152	535.00	IUUC-Hsa-046179
E3 activity/RING/RING	99.61	8.00e-152	533.00	IUUC-Mmu-063206
E3 activity/RING/RING	99.61	6.00e-152	533.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Loxodonta africana

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

ASVPAGGAKI SGSGSGFGDC GGADPVSPQH HELTSLFECP CFDYVLPPIL QCQAGHLVCN 60
QCRQKLSCCP TCRGALTPSI RNLAMEKVAS AVLFPCKYAT TGCSLTLHHT EKPEHEDICE 120

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Nucleotide Sequence
(Fasta)

GCATCGGTCC CAGCCGGGGG AGCGAAGATC TCTGGCTCCG GAAGCGGCTT CGGCGACTGT 60
GGCGGGGCCG ACCCGGTGTC CCCGCAGCAC CACGAGCTGA CCTCGCTCTT CGAGTGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	1.00e-153	535.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	1.00e-139	488.00
IUUC-Bta-012750	Bos taurus	99.22	2.00e-151	528.00
IUUC-Cja-019800	Callithrix jacchus	99.61	7.00e-152	529.00
IUUC-Cfa-020505	Canis familiaris	99.22	2.00e-151	527.00
IUUC-Cpo-021394	Cavia porcellus	98.84	6.00e-152	529.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.61	7.00e-152	529.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	8.00e-152	529.00
IUUC-Dre-027711	Danio rerio	91.30	2.00e-139	488.00
IUUC-Dno-029260	Dasypus novemcinctus	90.65	4.00e-147	513.00
IUUC-Dor-030489	Dipodomys ordii	96.22	2.00e-107	380.00
IUUC-Ete-032946	Echinops telfairi	98.84	4.00e-154	536.00
IUUC-Eca-033546	Equus caballus	92.93	2.00e-155	541.00
IUUC-Eeu-034861	Erinaceus europaeus	95.75	1.00e-147	515.00
IUUC-Fal-037160	Ficedula albicollis	88.05	5.00e-131	459.00
IUUC-Gmo-039091	Gadus morhua	89.33	2.00e-137	481.00
IUUC-Gga-040252	Gallus gallus	97.28	8.00e-150	522.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	9.00e-138	482.00
IUUC-Ggo-044618	Gorilla gorilla	99.61	7.00e-152	529.00
IUUC-Hsa-046179	Homo sapiens	99.61	7.00e-152	529.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	2.00e-151	527.00
IUUC-Lch-049496	Latimeria chalumnae	90.36	8.00e-150	522.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	1.00e-139	488.00
IUUC-Mcc-055023	Macaca mulatta	99.61	7.00e-152	529.00
IUUC-Meu-055922	Macropus eugenii	96.86	2.00e-147	514.00
IUUC-Mga-060070	Meleagris gallopavo	91.27	8.00e-147	512.00
IUUC-Mmr-061494	Microcebus murinus	99.61	7.00e-152	529.00
IUUC-Mdo-061971	Monodelphis domestica	98.43	1.00e-150	525.00
IUUC-Mmu-063206	Mus musculus	99.61	4.00e-151	527.00
IUUC-Mpu-066597	Mustela putorius furo	99.61	7.00e-152	529.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	3.00e-151	527.00
IUUC-Nle-069342	Nomascus leucogenys	99.61	7.00e-152	529.00
IUUC-Opr-070341	Ochotona princeps	56.86	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	8.00e-139	486.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	5.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.22	2.00e-153	534.00
IUUC-Oga-089154	Otolemur garnettii	99.61	7.00e-152	529.00
IUUC-Oar-089446	Ovis aries	98.08	3.00e-153	533.00
IUUC-Ptr-091088	Pan troglodytes	99.61	7.00e-152	529.00
IUUC-Psi-093079	Pelodiscus sinensis	98.48	6.00e-155	539.00
IUUC-Pfo-097007	Poecilia formosa	84.98	3.00e-131	461.00
IUUC-Pab-098092	Pongo abelii	99.61	7.00e-152	529.00
IUUC-Pca-100328	Procavia capensis	96.47	2.00e-146	511.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	4.00e-64	238.00
IUUC-Rno-105477	Rattus norvegicus	99.61	4.00e-151	527.00
IUUC-Sha-107630	Sarcophilus harrisii	98.10	1.00e-154	538.00
IUUC-Ssc-116441	Sus scrofa	99.22	1.00e-151	528.00
IUUC-Tru-118004	Takifugu rubripes	86.96	5.00e-133	466.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	2.00e-67	248.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	1.00e-135	475.00
IUUC-Vpa-130799	Vicugna pacos	99.42	4.00e-103	366.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence