iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004018.2	ENSOGAT00000004020.2	ENSOGAP00000003578.2
ENSOGAG00000004018.2	ENSOGAT00000027066.1	ENSOGAP00000021483.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.10e-55	184.8	6	136
UBD/UBC-like/UBD_UBC	8.60e-78	259.1	6	135

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeee 90
           + +el++l++dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+tki+hPn+++nG++Cl+il+  +
   Q: 6    ISQELTDLQRDPPAQCSAGPVGN-DLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILR--S 91
           679********************.9************************************************************9..* PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaaellkknreeykk 135
           +Wspal+v++vllsi+sll++pnp++pl  e+a+++k++re+y +
   Q: 92   QWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHIYKADREKYAS 136
           *******************************************87 PP

UBD/UBC-like/UBD_UBC

   S: 2    ikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqws 90
           i +el dl+rd++aq+sa++v++dlf+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+tkiyhpninsngsicldilrsqws
   Q: 6    ISQELTDLQRDPPAQCSAGPVGNDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWS 94
           889************************************************************************************** PP
   S: 91   aaltlskvllslcslladaepddplvaeiariyktdkekyk 131
           +alt+skvlls+csll+d++pddplv+eia+iyk+d+eky 
   Q: 95   PALTVSKVLLSICSLLCDPNPDDPLVPEIAHIYKADREKYA 135
           ****************************************7 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

VRRNAISQEL TDLQRDPPAQ CSAGPVGNDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGGAGGA ATGCCATAAG CCAGGTGAGA ACTTTGTACA TGTACACATG TACAAACGGG 60
TTTGCCATCT TCTGAAGAGT TTCACTGCCA CATGATGTAC CAGGAATGTG AGGTTACTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012632	Bos taurus	91.61	8.00e-75	271.00
IUUC-Itr-047868	Ictidomys tridecemlineatus	95.49	3.00e-72	263.00
IUUC-Oar-090224	Ovis aries	90.97	1.00e-74	271.00
IUUC-Tru-118588	Takifugu rubripes	92.48	3.00e-71	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence