iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068830

Ensembl Protein ID

EAA36539

UniProt Accession

Q7SI17; NACA_NEUCR

Genbank Protein ID

EAA36539.1

Protein Name

Nascent polypeptide-associated complex subunit alpha; Alpha-NAC; Nascent poypeptide complex protein 1

Genbank Nucleotide ID

CM002236

Gene Name

npc-1; egd2; NCU00635

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU00635	EAA36539	EAA36539

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	44.59	7.00e-15	75.10	IUUC-Sce-106371
UBD/Alpha-Helix/UBA	50.00	4.00e-28	119.00	IUUC-Spo-108121

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neurospora crassa

Functional Description
(View)

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Npc-1/egd2 may also be involved in transcription regulation (By similarity).

Protein Sequence
(Fasta)

MADPRVEELP EEEVKKTQVE DLDNSSDDES DIEAGDSSLP AGSQAVIHSR NEKKARKAIE 60
KLHLQRVPGI TRVTLRRPKN ILFVINNPEV YKSPNSNTYI VFGEAKIEDL NASAQAAAAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAGCTGGG CAGTGGCTGC TGTGCCCGGT CGAGCGATCA CACACCGGGG CCGGGGGCGT 60
GCACGCACTT TTGGTGAATT TTGGATCCCG AACTTTTTCT CTCCCACCAC GCCTTGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom

PROSITE

PS51151--NAC_AB

Pfam

PF01849--NAC

SMART

SM01407--NAC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0015031--P:protein transport

KEGG

ncr:NCU00635

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001167	Aegilops tauschii	42.96	1.00e-24	104.00
IUUC-Aml-002185	Ailuropoda melanoleuca	51.30	1.00e-26	114.00
IUUC-Atr-002586	Amborella trichopoda	43.04	1.00e-19	87.40
IUUC-Apl-003190	Anas platyrhynchos	48.75	1.00e-28	116.00
IUUC-Aca-005265	Anolis carolinensis	54.25	9.00e-34	134.00
IUUC-Aly-006397	Arabidopsis lyrata	49.30	2.00e-25	106.00
IUUC-Ath-007378	Arabidopsis thaliana	46.85	5.00e-23	99.00
IUUC-Ago-007936	Ashbya gossypii	45.51	1.00e-28	117.00
IUUC-Acl-008036	Aspergillus clavatus	69.44	2.00e-35	140.00
IUUC-Afl-008462	Aspergillus flavus	72.07	4.00e-41	159.00
IUUC-Afu-008832	Aspergillus fumigatus	67.59	5.00e-32	128.00
IUUC-Ani-009246	Aspergillus nidulans	67.57	3.00e-37	145.00
IUUC-Ang-009808	Aspergillus niger	66.67	1.00e-35	140.00
IUUC-Aor-009972	Aspergillus oryzae	72.07	4.00e-41	159.00
IUUC-Ame-011674	Astyanax mexicanus	54.90	1.00e-34	137.00
IUUC-Bgr-012162	Blumeria graminis	89.06	7.00e-30	121.00
IUUC-Bta-012508	Bos taurus	56.21	5.00e-34	135.00
IUUC-Bci-013643	Botrytis cinerea	69.30	1.00e-34	137.00
IUUC-Bdi-014874	Brachypodium distachyon	42.96	1.00e-22	97.40
IUUC-Bol-015132	Brassica oleracea	50.00	7.00e-26	108.00
IUUC-Bra-017630	Brassica rapa	47.89	6.00e-24	102.00
IUUC-Cel-018111	Caenorhabditis elegans	52.94	6.00e-35	138.00
IUUC-Cja-019846	Callithrix jacchus	44.15	8.00e-28	118.00
IUUC-Cfa-020429	Canis familiaris	56.21	5.00e-34	135.00
IUUC-Cpo-022542	Cavia porcellus	57.05	3.00e-33	132.00
IUUC-Cre-022679	Chlamydomonas reinhardtii	48.37	1.00e-33	133.00
IUUC-Csa-023260	Chlorocebus sabaeus	52.29	9.00e-29	121.00
IUUC-Cho-024869	Choloepus hoffmanni	72.97	5.00e-11	58.90
IUUC-Cin-025166	Ciona intestinalis	54.25	1.00e-31	127.00
IUUC-Csv-026284	Ciona savignyi	53.52	7.00e-25	103.00
IUUC-Cgl-026520	Colletotrichum gloeosporioides	75.68	8.00e-42	161.00
IUUC-Cne-026920	Cryptococcus neoformans	61.54	1.00e-25	107.00
IUUC-Cme-027301	Cyanidioschyzon merolae	39.29	2.00e-20	90.50
IUUC-Dre-028709	Danio rerio	56.21	2.00e-33	136.00
IUUC-Dno-029367	Dasypus novemcinctus	47.71	2.00e-27	117.00
IUUC-Dor-030962	Dipodomys ordii	56.21	7.00e-34	134.00
IUUC-Dme-032061	Drosophila melanogaster	52.90	7.00e-26	108.00
IUUC-Ete-032965	Echinops telfairi	52.29	4.00e-33	132.00
IUUC-Eca-034049	Equus caballus	55.56	3.00e-33	132.00
IUUC-Eeu-034673	Erinaceus europaeus	56.21	5.00e-34	135.00
IUUC-Fca-035429	Felis catus	51.95	1.00e-27	117.00
IUUC-Fal-037006	Ficedula albicollis	56.21	1.00e-33	134.00
IUUC-Fox-037704	Fusarium oxysporum	73.46	4.00e-58	215.00
IUUC-Fso-038247	Fusarium solani	70.14	4.00e-61	225.00
IUUC-Gmo-039002	Gadus morhua	53.59	3.00e-31	125.00
IUUC-Ggr-039888	Gaeumannomyces graminis	81.98	4.00e-44	168.00
IUUC-Gga-040237	Gallus gallus	56.21	1.00e-33	134.00
IUUC-Gac-041800	Gasterosteus aculeatus	56.21	2.00e-33	134.00
IUUC-Gma-043275	Glycine max	48.03	8.00e-30	121.00
IUUC-Ggo-045163	Gorilla gorilla	45.90	2.00e-31	127.00
IUUC-Hsa-045795	Homo sapiens	56.21	4.00e-29	123.00
IUUC-Hvu-047376	Hordeum vulgare	42.25	1.00e-24	104.00
IUUC-Itr-048152	Ictidomys tridecemlineatus	56.21	5.00e-34	135.00
IUUC-Kpa-049166	Komagataella pastoris	43.65	2.00e-26	110.00
IUUC-Lch-050076	Latimeria chalumnae	56.21	3.00e-34	135.00
IUUC-Lpe-051258	Leersia perrieri	48.59	3.00e-26	109.00
IUUC-Loc-052292	Lepisosteus oculatus	57.05	4.00e-33	132.00
IUUC-Lma-053293	Leptosphaeria maculans	63.06	5.00e-33	132.00
IUUC-Laf-054393	Loxodonta africana	45.86	8.00e-32	128.00
IUUC-Mcc-054632	Macaca mulatta	56.21	4.00e-29	122.00
IUUC-Meu-056242	Macropus eugenii	55.38	2.00e-25	107.00
IUUC-Mor-057099	Magnaporthe oryzae	81.98	4.00e-43	165.00
IUUC-Mpo-057543	Magnaporthe poae	79.00	4.00e-36	142.00
IUUC-Mtr-058769	Medicago truncatula	47.80	2.00e-22	96.70
IUUC-Mla-059166	Melampsora laricipopulina	41.56	8.00e-23	97.80
IUUC-Mga-059406	Meleagris gallopavo	56.21	2.00e-33	133.00
IUUC-Mvi-060390	Microbotryum violaceum	36.91	1.00e-21	93.60
IUUC-Mmr-061569	Microcebus murinus	56.21	5.00e-34	135.00
IUUC-Mdo-062077	Monodelphis domestica	56.21	1.00e-33	135.00
IUUC-Mmu-063984	Mus musculus	72.97	9.00e-11	62.00
IUUC-Mac-065175	Musa acuminata	48.59	6.00e-28	115.00
IUUC-Mpu-066751	Mustela putorius furo	45.36	5.00e-27	115.00
IUUC-Mlu-068234	Myotis lucifugus	56.21	5.00e-34	135.00
IUUC-Nfi-068541	Neosartorya fischeri	67.59	5.00e-32	128.00
IUUC-Nle-069126	Nomascus leucogenys	56.21	7.00e-34	135.00
IUUC-Opr-070742	Ochotona princeps	56.21	7.00e-34	135.00
IUUC-Ont-071828	Oreochromis niloticus	56.21	3.00e-33	132.00
IUUC-Oan-073462	Ornithorhynchus anatinus	57.05	2.00e-28	119.00
IUUC-Ocu-074890	Oryctolagus cuniculus	47.71	8.00e-28	118.00
IUUC-Oba-075995	Oryza barthii	45.07	5.00e-27	112.00
IUUC-Obr-076668	Oryza brachyantha	45.64	6.00e-28	115.00
IUUC-Ogl-077445	Oryza glaberrima	45.07	5.00e-27	112.00
IUUC-Ogu-078606	Oryza glumaepatula	45.07	5.00e-27	112.00
IUUC-Oin-079287	Oryza indica	45.07	5.00e-27	112.00
IUUC-Olo-080686	Oryza longistaminata	39.29	4.00e-23	99.00
IUUC-Ome-081567	Oryza meridionalis	45.64	1.00e-27	113.00
IUUC-Oni-082873	Oryza nivara	45.07	5.00e-27	112.00
IUUC-Opu-083291	Oryza punctata	45.64	2.00e-27	113.00
IUUC-Oru-084592	Oryza rufipogon	45.07	5.00e-27	112.00
IUUC-Osa-086102	Oryza sativa	45.07	5.00e-27	112.00
IUUC-Ola-087531	Oryzias latipes	54.25	4.00e-34	135.00
IUUC-Olu-087895	Ostreococcus lucimarinus	40.85	5.00e-24	100.00
IUUC-Oga-088239	Otolemur garnettii	56.21	5.00e-34	135.00
IUUC-Oar-090371	Ovis aries	52.60	5.00e-27	115.00
IUUC-Ptr-090481	Pan troglodytes	47.54	9.00e-26	111.00
IUUC-Pan-092210	Papio anubis	52.29	2.00e-28	120.00
IUUC-Psi-093588	Pelodiscus sinensis	56.21	5.00e-34	135.00
IUUC-Pma-094702	Petromyzon marinus	55.56	4.00e-33	132.00
IUUC-Pno-094927	Phaeosphaeria nodorum	65.77	3.00e-34	135.00
IUUC-Ppa-095389	Physcomitrella patens	62.90	5.00e-21	92.00
IUUC-Pfo-096744	Poecilia formosa	57.52	9.00e-34	134.00
IUUC-Pab-098044	Pongo abelii	56.21	5.00e-34	135.00
IUUC-Pop-099384	Populus trichocarpa	50.00	5.00e-33	132.00
IUUC-Pca-100355	Procavia capensis	47.71	6.00e-28	118.00
IUUC-Ppe-101786	Prunus persica	48.59	9.00e-29	117.00
IUUC-Pva-102494	Pteropus vampyrus	54.25	5.00e-34	135.00
IUUC-Pgr-103303	Puccinia graminis	65.62	1.00e-20	90.90
IUUC-Ptt-103748	Puccinia triticina	70.45	2.00e-13	67.40
IUUC-Pte-104368	Pyrenophora teres	66.67	6.00e-34	135.00
IUUC-Pyt-104542	Pyrenophora triticirepentis	64.86	2.00e-33	133.00
IUUC-Rno-105387	Rattus norvegicus	56.21	3.00e-33	136.00
IUUC-Sce-106371	Saccharomyces cerevisiae	44.59	5.00e-16	75.10
IUUC-Sha-107189	Sarcophilus harrisii	56.21	5.00e-34	135.00
IUUC-Sja-107942	Schizosaccharomyces japonicus	51.22	2.00e-29	119.00
IUUC-Spo-108121	Schizosaccharomyces pombe	50.00	6.00e-31	124.00
IUUC-Ssl-108595	Sclerotinia sclerotiorum	71.05	2.00e-37	146.00
IUUC-Smo-108783	Selaginella moellendorffii	50.70	5.00e-27	112.00
IUUC-Sit-110180	Setaria italica	50.70	1.00e-28	117.00
IUUC-Sly-110957	Solanum lycopersicum	45.77	4.00e-26	108.00
IUUC-Stu-112873	Solanum tuberosum	43.66	8.00e-24	101.00
IUUC-Sar-113668	Sorex araneus	72.97	6.00e-11	58.90
IUUC-Sbi-114328	Sorghum bicolor	49.30	1.00e-27	114.00
IUUC-Sre-115220	Sporisorium reilianum	48.42	1.00e-19	87.80
IUUC-Ssc-116119	Sus scrofa	56.21	5.00e-34	135.00
IUUC-Tgu-116528	Taeniopygia guttata	57.05	4.00e-33	132.00
IUUC-Tru-117538	Takifugu rubripes	56.86	3.00e-34	136.00
IUUC-Tsy-118855	Tarsius syrichta	72.97	7.00e-11	58.20
IUUC-Tni-120134	Tetraodon nigroviridis	54.25	4.00e-34	135.00
IUUC-Tca-121524	Theobroma cacao	50.00	6.00e-29	118.00
IUUC-Tre-121915	Trichoderma reesei	75.44	1.00e-36	144.00
IUUC-Tvi-122411	Trichoderma virens	77.06	6.00e-35	138.00
IUUC-Tae-123448	Triticum aestivum	42.96	6.00e-25	105.00
IUUC-Tur-126821	Triticum urartu	42.96	8.00e-25	104.00
IUUC-Tme-126875	Tuber melanosporum	63.96	1.00e-30	124.00
IUUC-Tbe-127759	Tupaia belangeri	47.89	5.00e-24	102.00
IUUC-Ttr-129124	Tursiops truncatus	52.98	3.00e-28	119.00
IUUC-Uma-129551	Ustilago maydis	44.85	4.00e-28	115.00
IUUC-Vda-129992	Verticillium dahliae	65.22	5.00e-53	198.00
IUUC-Vpa-130096	Vicugna pacos	54.90	5.00e-31	125.00
IUUC-Vvi-130940	Vitis vinifera	47.89	2.00e-23	100.00
IUUC-Xtr-132454	Xenopus tropicalis	56.21	3.00e-33	133.00
IUUC-Xma-133842	Xiphophorus maculatus	57.52	2.00e-33	134.00
IUUC-Yli-134485	Yarrowia lipolytica	55.38	5.00e-18	82.00
IUUC-Zma-135748	Zea mays	50.00	8.00e-28	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence