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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046852
Ensembl Protein ID ENSP00000380024.4
UniProt Accession Q9UNL4; A4KYM4; A4KYM6; D3DUR8; Q0EF62; Q0EF63; Q4VBQ6; Q96E15; Q9H3J0; ING4_HUMAN; ING4_v1; ING4_v4; ING4_v2; ING4_v3
Genbank Protein ID AAL79773.1; BAF30477.1; BAF30478.1; BAF30479.1; ABO61139.1; ABO61141.1; AAG43153.1; AAD48585.1; EAW88763.1; EAW88768.1; EAW88770.1; EAW88772.1; AAH07781.1; AAH13038.2; AAH95434.1
Protein Name Inhibitor of growth protein 4; p29ING4
Genbank Nucleotide ID AF156552; AB197695; AB197696; AB197697; EF152349; EF152351; AF063594; AF110645; CH471116; CH471116; CH471116; CH471116; BC007781; BC013038; BC095434
Gene Name ING4; My036
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111653.19 ENST00000341550.8 ENSP00000343396.4
ENSG00000111653.19 ENST00000396807.8 ENSP00000380024.4
ENSG00000111653.19 ENST00000446105.6 ENSP00000415903.2
ENSG00000111653.19 ENST00000469749.5 ENSP00000433081.1
ENSG00000111653.19 ENST00000488381.5 ENSP00000431892.1
ENSG00000111653.19 ENST00000423703.6 ENSP00000414008.2
ENSG00000111653.19 ENST00000412586.6 ENSP00000412705.2
ENSG00000111653.19 ENST00000444704.5 ENSP00000397343.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRecordsRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/PHD PHD 23624912
Classification
Family E-value Score Start End
E3 activity/RING/PHD 2.30e-09 38.9 197 244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 197  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 244
           69*.*******99..********999***********...899996.******97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
Protein Sequence
(Fasta)
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 60
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046852|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACAGTCACTT CCGGGGCGGA TCGGAAGTTG CTTTGTTTTG CTTCGAGATG GCTGCGGGGA 60
TGTATTTGGA ACATTATCTG GACAGTAAGA GCAGGCTGGA GGTGGGGGTC GGGGCTGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046852|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0006473--P:protein acetylation
KEGG hsa:51147
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001338 Ailuropoda melanoleuca 98.80 2.00e-126 444.00
IUUC-Apl-004097 Anas platyrhynchos 93.55 5.00e-119 419.00
IUUC-Aca-004593 Anolis carolinensis 96.79 1.00e-124 439.00
IUUC-Ame-011133 Astyanax mexicanus 80.08 3.00e-116 410.00
IUUC-Bta-012699 Bos taurus 97.59 3.00e-126 444.00
IUUC-Bdi-014504 Brachypodium distachyon 35.86 4.00e-39 154.00
IUUC-Bol-015245 Brassica oleracea 31.33 6.00e-30 124.00
IUUC-Bra-017027 Brassica rapa 31.73 2.00e-30 125.00
IUUC-Cja-019988 Callithrix jacchus 100.00 5.00e-121 426.00
IUUC-Cfa-021282 Canis familiaris 99.20 6.00e-120 423.00
IUUC-Cpo-022011 Cavia porcellus 99.20 2.00e-130 457.00
IUUC-Cre-022920 Chlamydomonas reinhardtii 31.23 7.00e-29 120.00
IUUC-Csa-023203 Chlorocebus sabaeus 100.00 5.00e-121 426.00
IUUC-Cin-025479 Ciona intestinalis 61.76 1.00e-79 289.00
IUUC-Csv-026288 Ciona savignyi 55.43 4.00e-75 274.00
IUUC-Dre-028264 Danio rerio 79.68 1.00e-114 405.00
IUUC-Dno-029766 Dasypus novemcinctus 96.37 1.00e-113 402.00
IUUC-Dor-031136 Dipodomys ordii 84.32 2.00e-98 352.00
IUUC-Dme-032200 Drosophila melanogaster 84.00 2.00e-40 159.00
IUUC-Eca-033565 Equus caballus 99.20 3.00e-130 457.00
IUUC-Eeu-034948 Erinaceus europaeus 80.57 4.00e-99 353.00
IUUC-Fca-036368 Felis catus 99.60 2.00e-120 425.00
IUUC-Fal-037120 Ficedula albicollis 93.15 1.00e-117 415.00
IUUC-Gmo-038982 Gadus morhua 81.20 1.00e-115 408.00
IUUC-Gga-040771 Gallus gallus 96.79 1.00e-124 439.00
IUUC-Gac-042184 Gasterosteus aculeatus 80.49 8.00e-112 396.00
IUUC-Gma-044339 Glycine max 29.37 1.00e-33 136.00
IUUC-Ggo-045559 Gorilla gorilla 100.00 5.00e-121 426.00
IUUC-Hvu-047046 Hordeum vulgare 36.11 4.00e-38 151.00
IUUC-Itr-047978 Ictidomys tridecemlineatus 98.80 6.00e-130 456.00
IUUC-Kpa-049229 Komagataella pastoris 59.18 2.00e-16 79.70
IUUC-Lpe-050822 Leersia perrieri 34.66 5.00e-38 150.00
IUUC-Laf-054057 Loxodonta africana 99.60 2.00e-120 425.00
IUUC-Mcc-055212 Macaca mulatta 93.63 4.00e-115 407.00
IUUC-Meu-056511 Macropus eugenii 98.31 5.00e-121 426.00
IUUC-Mtr-058288 Medicago truncatula 32.22 8.00e-33 134.00
IUUC-Mga-059967 Meleagris gallopavo 94.33 2.00e-118 418.00
IUUC-Mmr-060843 Microcebus murinus 97.59 2.00e-126 444.00
IUUC-Mdo-062357 Monodelphis domestica 98.39 1.00e-129 455.00
IUUC-Mmu-064093 Mus musculus 99.20 2.00e-130 457.00
IUUC-Mpu-066923 Mustela putorius furo 87.95 1.00e-97 348.00
IUUC-Mlu-067754 Myotis lucifugus 91.67 2.00e-118 417.00
IUUC-Nle-069062 Nomascus leucogenys 100.00 5.00e-121 426.00
IUUC-Opr-070207 Ochotona princeps 92.37 2.00e-111 394.00
IUUC-Ont-072446 Oreochromis niloticus 81.60 2.00e-114 404.00
IUUC-Ocu-074235 Oryctolagus cuniculus 99.20 6.00e-120 423.00
IUUC-Obr-076266 Oryza brachyantha 35.46 7.00e-37 147.00
IUUC-Ogl-077118 Oryza glaberrima 33.33 3.00e-36 145.00
IUUC-Oin-079049 Oryza indica 33.86 4.00e-35 141.00
IUUC-Ome-081291 Oryza meridionalis 33.73 8.00e-37 147.00
IUUC-Oni-082218 Oryza nivara 33.86 4.00e-35 141.00
IUUC-Opu-084171 Oryza punctata 34.13 6.00e-36 144.00
IUUC-Osa-085563 Oryza sativa 33.73 8.00e-37 147.00
IUUC-Ola-086429 Oryzias latipes 76.80 2.00e-105 375.00
IUUC-Olu-087851 Ostreococcus lucimarinus 34.57 1.00e-19 90.10
IUUC-Oga-089123 Otolemur garnettii 99.60 2.00e-120 425.00
IUUC-Oar-089524 Ovis aries 97.59 3.00e-126 444.00
IUUC-Ptr-090908 Pan troglodytes 99.60 2.00e-120 425.00
IUUC-Pan-092837 Papio anubis 99.20 5.00e-127 446.00
IUUC-Psi-093828 Pelodiscus sinensis 96.14 1.00e-113 402.00
IUUC-Ppa-096009 Physcomitrella patens 33.20 6.00e-34 137.00
IUUC-Pfo-096617 Poecilia formosa 81.20 2.00e-114 404.00
IUUC-Pab-097978 Pongo abelii 99.58 2.00e-110 391.00
IUUC-Pop-099415 Populus trichocarpa 73.68 2.00e-26 112.00
IUUC-Pca-100475 Procavia capensis 66.67 5.00e-85 307.00
IUUC-Ppe-101441 Prunus persica 32.81 3.00e-36 144.00
IUUC-Pva-102325 Pteropus vampyrus 99.20 3.00e-130 457.00
IUUC-Rno-105178 Rattus norvegicus 97.59 3.00e-136 477.00
IUUC-Sha-106773 Sarcophilus harrisii 98.39 1.00e-129 456.00
IUUC-Sit-109827 Setaria italica 34.66 2.00e-36 145.00
IUUC-Sly-111750 Solanum lycopersicum 33.86 5.00e-36 144.00
IUUC-Stu-112250 Solanum tuberosum 33.86 5.00e-36 144.00
IUUC-Sbi-114826 Sorghum bicolor 35.86 2.00e-37 148.00
IUUC-Sre-115124 Sporisorium reilianum 58.21 3.00e-22 100.00
IUUC-Ssc-115797 Sus scrofa 92.68 1.00e-104 372.00
IUUC-Tgu-117270 Taeniopygia guttata 96.79 1.00e-124 439.00
IUUC-Tru-118253 Takifugu rubripes 80.48 1.00e-114 405.00
IUUC-Tca-121597 Theobroma cacao 69.84 3.00e-28 118.00
IUUC-Tae-123043 Triticum aestivum 35.94 1.00e-37 149.00
IUUC-Tbe-127558 Tupaia belangeri 98.80 2.00e-126 444.00
IUUC-Ttr-128300 Tursiops truncatus 99.09 4.00e-65 241.00
IUUC-Uma-129581 Ustilago maydis 57.63 4.00e-21 97.10
Created Date 25-Jun-2017

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