iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090771

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Tripartite motif containing 25

Genbank Nucleotide ID

AACZ03107546

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009432.5	ENSPTRT00000017303.4	ENSPTRP00000016020.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.90e-09	35.7	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle+fk+ p+++pCgH f+ +Cl + w     ++    +CP Cr
   Q: 13   CSICLEPFKE-PVTTPCGHNFCGSCLnETW----AVQGAPYLCPQCR 54
           ********99.****************9**....8999999*****8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAELCPLAEE LSCSICLEPF KEPVTTPCGH NFCGSCLNET WAVQGAPYLC PQCRAVYQAR 60
PQLHKNTVLC NVVEQFLQAD LAREPPADGW TPPARASAPS PDAQVACDHC LKEAAVKTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCCTCGG CGGCCTGGGA GCGCGGGTGC AGCAGTTGCG TCCCGACCCC CGGGAGCGCC 60
ATGGCAGAGC TGTGCCCCCT GGCCGAGGAG CTGTCGTGCT CCATCTGCCT GGAGCCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	77.06	0.00e+00	961.00
IUUC-Apl-004101	Anas platyrhynchos	49.06	2.00e-165	575.00
IUUC-Aca-005025	Anolis carolinensis	49.06	2.00e-172	599.00
IUUC-Bta-012735	Bos taurus	74.65	0.00e+00	937.00
IUUC-Cja-019996	Callithrix jacchus	82.65	0.00e+00	714.00
IUUC-Cfa-020466	Canis familiaris	76.77	0.00e+00	958.00
IUUC-Cpo-021737	Cavia porcellus	70.93	0.00e+00	879.00
IUUC-Csa-023217	Chlorocebus sabaeus	94.29	0.00e+00	1149.00
IUUC-Cho-024346	Choloepus hoffmanni	50.84	2.00e-70	259.00
IUUC-Dre-027570	Danio rerio	34.07	6.00e-42	164.00
IUUC-Dno-030082	Dasypus novemcinctus	75.31	0.00e+00	934.00
IUUC-Dor-030335	Dipodomys ordii	53.92	8.00e-127	447.00
IUUC-Ete-032923	Echinops telfairi	68.70	0.00e+00	788.00
IUUC-Eca-033411	Equus caballus	75.23	0.00e+00	942.00
IUUC-Eeu-034656	Erinaceus europaeus	73.12	1.00e-161	563.00
IUUC-Fca-035371	Felis catus	77.52	0.00e+00	965.00
IUUC-Fal-037008	Ficedula albicollis	45.28	3.00e-156	545.00
IUUC-Gmo-038668	Gadus morhua	34.13	7.00e-103	367.00
IUUC-Gga-040608	Gallus gallus	47.52	2.00e-160	559.00
IUUC-Gac-041409	Gasterosteus aculeatus	51.65	3.00e-57	216.00
IUUC-Ggo-044518	Gorilla gorilla	98.26	0.00e+00	1164.00
IUUC-Hsa-045828	Homo sapiens	98.73	0.00e+00	1184.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	64.45	0.00e+00	796.00
IUUC-Lch-050478	Latimeria chalumnae	39.66	5.00e-70	258.00
IUUC-Loc-052864	Lepisosteus oculatus	36.36	3.00e-111	395.00
IUUC-Laf-054325	Loxodonta africana	77.72	1.00e-170	592.00
IUUC-Mcc-054920	Macaca mulatta	94.92	0.00e+00	1155.00
IUUC-Meu-056367	Macropus eugenii	72.83	3.00e-74	272.00
IUUC-Mga-059975	Meleagris gallopavo	48.98	3.00e-162	565.00
IUUC-Mmr-060748	Microcebus murinus	81.65	0.00e+00	988.00
IUUC-Mdo-062904	Monodelphis domestica	58.16	0.00e+00	694.00
IUUC-Mmu-063891	Mus musculus	73.23	0.00e+00	932.00
IUUC-Mpu-066473	Mustela putorius furo	76.86	0.00e+00	982.00
IUUC-Mlu-068185	Myotis lucifugus	77.69	0.00e+00	940.00
IUUC-Nle-070177	Nomascus leucogenys	96.35	0.00e+00	1167.00
IUUC-Opr-070558	Ochotona princeps	61.50	1.00e-146	512.00
IUUC-Ont-071368	Oreochromis niloticus	47.80	9.00e-53	201.00
IUUC-Ocu-074461	Oryctolagus cuniculus	68.57	6.00e-153	534.00
IUUC-Ogu-078203	Oryza glumaepatula	47.06	2.00e-10	60.10
IUUC-Opu-083547	Oryza punctata	48.53	9.00e-11	60.80
IUUC-Ola-087394	Oryzias latipes	30.03	1.00e-62	234.00
IUUC-Oga-088937	Otolemur garnettii	75.67	0.00e+00	941.00
IUUC-Oar-089781	Ovis aries	74.43	8.00e-179	619.00
IUUC-Pan-092830	Papio anubis	94.44	0.00e+00	1149.00
IUUC-Psi-093664	Pelodiscus sinensis	52.31	7.00e-179	620.00
IUUC-Pma-094147	Petromyzon marinus	28.07	1.00e-61	231.00
IUUC-Pfo-096528	Poecilia formosa	35.48	9.00e-111	394.00
IUUC-Pab-097588	Pongo abelii	96.03	0.00e+00	1168.00
IUUC-Pca-100890	Procavia capensis	70.75	0.00e+00	843.00
IUUC-Pva-102314	Pteropus vampyrus	81.04	0.00e+00	951.00
IUUC-Pgr-103377	Puccinia graminis	39.29	2.00e-06	47.00
IUUC-Ptt-103758	Puccinia triticina	39.29	6.00e-06	44.70
IUUC-Rno-105234	Rattus norvegicus	69.65	0.00e+00	899.00
IUUC-Sce-106362	Saccharomyces cerevisiae	44.93	7.00e-09	55.10
IUUC-Sha-106807	Sarcophilus harrisii	54.76	0.00e+00	648.00
IUUC-Sar-113283	Sorex araneus	60.13	9.00e-136	476.00
IUUC-Ssc-115878	Sus scrofa	81.70	1.00e-108	385.00
IUUC-Tgu-117026	Taeniopygia guttata	45.38	2.00e-127	448.00
IUUC-Tru-117794	Takifugu rubripes	36.05	8.00e-56	211.00
IUUC-Tbe-127580	Tupaia belangeri	72.77	2.00e-157	548.00
IUUC-Ttr-128648	Tursiops truncatus	74.48	0.00e+00	642.00
IUUC-Vpa-130254	Vicugna pacos	89.71	1.00e-97	350.00
IUUC-Xtr-132892	Xenopus tropicalis	42.73	3.00e-74	271.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence