iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096202

Ensembl Protein ID

ENSPFOP00000002975.2

UniProt Accession

A0A087XB22; A0A087XB22_POEFO

Genbank Protein ID

ENSPFOP00000002975

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01009602

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000002985.2	ENSPFOT00000002979.2	ENSPFOP00000002975.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-73	246.8	687	1010

Active Site

Position(s)	Description	Evidence
977	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k++l v+fv++  + +   +++f+   ++el  p+ ++f+y+e+++  ++p + +     e+ k+F ++G+l+g+al++++++
   Q: 687  HAAFKRELVVQFVEDRKIMN-VNKKDFFLHAFDELMAPESQMFMYNESQTLAWFPPKPQV----EEKKYF-LFGVLCGLALYNHNII 767
           5789999*******998877.7899*****************************999997....677888.55************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            lp++ +++k+ll++k sl+d++e+dp l++sl  ++e      + ++l+ tf+vs    g  k+ eL p+     Vt +N++e+v 
   Q: 768  HLPFPLALFKKLLRVKTSLDDMKEFDPVLAESLRCMLEDYT-PDDVEALETTFTVSW---GGGKA-ELDPNEPGKLVTGSNRKEFVA 849
           ********************************988887743.333334788888666...55555.5******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           + v++ ++++++  ++ f+eGf +v+++++++ F++eel+ ++ G e++d+e +k++t y+ggy++d+p+i++Fw+v+e+fs+ee+k
   Q: 850  AFVNHAFNKSVEGVFKLFKEGFFKVCNMDVVEFFQPEELQSVMVGHENYDWEVFKENTVYEGGYHADHPTIITFWRVFEDFSAEEKK 936
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYssk...eilkekLlyAieetkgFe 334
           +fL F+Tg++r+P+ G++ +k r+ ++++ a++++lP+s TC  +L LP+Y  +    +++ kLl Ai++++gF 
   Q: 937  KFLLFLTGCDRVPFLGMECIKMRVAMLQD-ATERHLPESLTCHTLLLLPNYRRYpveRTMETKLLRAINHNRGFW 1010
           *********************77666666.*******************9877533289**************95 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MQVFCWGDSS SGQFGVQATL SPVSWTGPGV VTNICCGEQH TLFLRSDGKV LSCGHNSQGQ 60
LGRKNQSGKM LGPVEGLGDV AAMACGQNHC LALCASGQVF SWGAGDDGQL GFATGPPSNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAGTCTTA TAATTTCGAC AGCACGTGAA AGCAGCAGCT CCAGCTGAAG TAGAGCGCCG 60
CTAGACGCCT CGGTCAGTCT ACGAGCAGAC ATGCAGGTGT TTTGTTGGGG AGACAGTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011023	Astyanax mexicanus	47.04	0.00e+00	854.00
IUUC-Cho-025101	Choloepus hoffmanni	35.60	2.00e-75	277.00
IUUC-Gmo-038792	Gadus morhua	52.72	0.00e+00	933.00
IUUC-Gac-041342	Gasterosteus aculeatus	68.02	0.00e+00	1331.00
IUUC-Loc-052736	Lepisosteus oculatus	49.09	0.00e+00	893.00
IUUC-Ont-071328	Oreochromis niloticus	72.85	0.00e+00	1468.00
IUUC-Tru-117816	Takifugu rubripes	58.82	0.00e+00	1114.00
IUUC-Tni-120770	Tetraodon nigroviridis	50.99	0.00e+00	905.00
IUUC-Tbe-127787	Tupaia belangeri	38.51	1.00e-85	311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence