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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046215
UUCD1 version UUC-HoS-01251
Ensembl Protein ID ENSP00000380336.3
UniProt Accession Q2TAY7; B4E3L0; Q9BU59; Q9HA96; Q9NVD1; SMU1_HUMAN
Genbank Protein ID BAA91822.1; BAG65522.1; CAI15554.1; AAH02876.1; AAI10655.1
Protein Name WD40 repeat-containing protein SMU1; Smu-1 suppressor of mec-8 and unc-52 protein homolog; WD40 repeat-containing protein SMU1, N-terminally processed
Genbank Nucleotide ID AK001667; AK022032; AL162590; BC002876; BC110654
Gene Name SMU1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122692.8 ENST00000397149.3 ENSP00000380336.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.10e-35 118.8 265 300
UBD/Beta-Prp 2.50e-55 189.4 213 512
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           d v c++f  d  +l++G+ Dg+ikvW + +g +l+
   Q: 265  DAVLCMCFsRDtEMLATGAQDGKIKVWKIQSGQCLR 300
           6799*****777********************9986 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheae.......vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk. 91
           +ks + c  fspd+++l+tgs dg i+vw++ttgk  + l ++ ++        v +++fs+d+++l+tg++D+ ikvw +++g+c++ ++ 
   Q: 213  QKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLkYQAQDNfmmmddaVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFEr 304
           678899******************************666644444446666666************************************98 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.....tgg 178
           +h++ v++lsfs++++ ++s+s d+tir+  l++g+ l+  ++gh+++vn +++ +dg +++s+s D+tv++W++kt ++  t+     t g
   Q: 305  AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLK-EFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFkslgsTAG 395
           9**************************************.********************************************88887555 PP
   S: 179  htdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnght...dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            +  v+s++ + +n +++v + + +tv + ++q g++vr++   +     + + ++sp++e+++++++D +++++ + +g+l +tl+ h++ 
   Q: 396  TDITVNSVIlLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKregGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKD 486
           777778887666666*****************5.66888888766566566678999*********************************** PP
   S: 267  visvavlsfgdnvlvlgsedskvniwk 293
           vi +a+ ++ +n +++ sed+ +++wk
   Q: 487  VIGIAH-HPHQNLIATYSEDGLLKLWK 512
           ******.*******************8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD INSGHWDTVL 60
QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQTQ PERYIHLENL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046215|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGACTGGC CTTGAGGGAG AGCTGGGGCC TGCTCCCGGA GAGATACGGC TATGTCGATC 60
GAAATCGAAT CTTCGGAGTG AGTCCTGCGG TGGGGATGTT CGCGCCTTGC CGGGGGCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046215|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR006595--CTLH_C
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
KEGG hsa:55234
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000857 Aegilops tauschii 60.27 1.00e-48 185.00
IUUC-Aml-001330 Ailuropoda melanoleuca 100.00 0.00e+00 1071.00
IUUC-Atr-002570 Amborella trichopoda 66.21 0.00e+00 724.00
IUUC-Apl-003826 Anas platyrhynchos 99.19 0.00e+00 1027.00
IUUC-Aca-005183 Anolis carolinensis 99.22 0.00e+00 1064.00
IUUC-Aly-005632 Arabidopsis lyrata 64.72 0.00e+00 720.00
IUUC-Ath-007219 Arabidopsis thaliana 64.72 0.00e+00 715.00
IUUC-Ame-011374 Astyanax mexicanus 95.91 0.00e+00 1042.00
IUUC-Bta-012890 Bos taurus 100.00 0.00e+00 1071.00
IUUC-Bdi-014061 Brachypodium distachyon 65.04 0.00e+00 728.00
IUUC-Bol-016332 Brassica oleracea 65.04 0.00e+00 722.00
IUUC-Bra-017612 Brassica rapa 64.91 0.00e+00 723.00
IUUC-Cel-018238 Caenorhabditis elegans 62.04 0.00e+00 678.00
IUUC-Cja-019336 Callithrix jacchus 100.00 0.00e+00 1071.00
IUUC-Cfa-021108 Canis familiaris 99.81 0.00e+00 1070.00
IUUC-Cpo-022052 Cavia porcellus 100.00 0.00e+00 1071.00
IUUC-Cre-022595 Chlamydomonas reinhardtii 59.77 0.00e+00 658.00
IUUC-Csa-023488 Chlorocebus sabaeus 100.00 0.00e+00 1071.00
IUUC-Cho-025010 Choloepus hoffmanni 89.86 0.00e+00 944.00
IUUC-Cin-025251 Ciona intestinalis 82.10 0.00e+00 901.00
IUUC-Csv-026092 Ciona savignyi 75.66 0.00e+00 827.00
IUUC-Dre-027382 Danio rerio 95.71 0.00e+00 1034.00
IUUC-Dno-029007 Dasypus novemcinctus 99.81 0.00e+00 1071.00
IUUC-Dor-030180 Dipodomys ordii 86.51 0.00e+00 697.00
IUUC-Dme-031762 Drosophila melanogaster 77.97 0.00e+00 869.00
IUUC-Ete-032933 Echinops telfairi 99.77 0.00e+00 892.00
IUUC-Eca-033864 Equus caballus 100.00 0.00e+00 1054.00
IUUC-Eeu-034635 Erinaceus europaeus 89.36 0.00e+00 788.00
IUUC-Fca-036119 Felis catus 100.00 0.00e+00 1071.00
IUUC-Fal-037396 Ficedula albicollis 99.60 0.00e+00 1042.00
IUUC-Gmo-038962 Gadus morhua 93.37 0.00e+00 1019.00
IUUC-Gga-040134 Gallus gallus 99.61 0.00e+00 1069.00
IUUC-Gac-041630 Gasterosteus aculeatus 93.76 0.00e+00 1019.00
IUUC-Gma-043928 Glycine max 66.21 0.00e+00 734.00
IUUC-Ggo-045061 Gorilla gorilla 99.61 0.00e+00 1066.00
IUUC-Hvu-047799 Hordeum vulgare 66.67 5.00e-148 516.00
IUUC-Itr-048826 Ictidomys tridecemlineatus 100.00 0.00e+00 1071.00
IUUC-Lch-050209 Latimeria chalumnae 92.02 0.00e+00 976.00
IUUC-Lpe-050740 Leersia perrieri 65.23 0.00e+00 726.00
IUUC-Loc-052739 Lepisosteus oculatus 88.82 0.00e+00 954.00
IUUC-Laf-053895 Loxodonta africana 99.81 0.00e+00 1067.00
IUUC-Mcc-055183 Macaca mulatta 100.00 0.00e+00 1071.00
IUUC-Mtr-057730 Medicago truncatula 65.23 0.00e+00 712.00
IUUC-Mga-059222 Meleagris gallopavo 99.52 0.00e+00 881.00
IUUC-Mmr-061749 Microcebus murinus 99.03 0.00e+00 1057.00
IUUC-Mdo-062920 Monodelphis domestica 99.61 0.00e+00 1069.00
IUUC-Mmu-063228 Mus musculus 100.00 0.00e+00 1071.00
IUUC-Mac-065084 Musa acuminata 66.41 0.00e+00 740.00
IUUC-Mpu-066162 Mustela putorius furo 100.00 0.00e+00 1071.00
IUUC-Mlu-067471 Myotis lucifugus 99.03 0.00e+00 1064.00
IUUC-Nle-070129 Nomascus leucogenys 100.00 0.00e+00 1071.00
IUUC-Opr-071176 Ochotona princeps 100.00 0.00e+00 1054.00
IUUC-Ont-071830 Oreochromis niloticus 95.13 0.00e+00 1033.00
IUUC-Oan-072778 Ornithorhynchus anatinus 99.61 0.00e+00 1070.00
IUUC-Ocu-074570 Oryctolagus cuniculus 100.00 0.00e+00 1071.00
IUUC-Oba-075507 Oryza barthii 65.23 0.00e+00 728.00
IUUC-Obr-076672 Oryza brachyantha 65.62 0.00e+00 732.00
IUUC-Ogl-077110 Oryza glaberrima 65.23 0.00e+00 728.00
IUUC-Ogu-077976 Oryza glumaepatula 65.23 0.00e+00 728.00
IUUC-Oin-079525 Oryza indica 65.23 0.00e+00 728.00
IUUC-Olo-080391 Oryza longistaminata 63.57 0.00e+00 719.00
IUUC-Oni-082778 Oryza nivara 65.23 0.00e+00 728.00
IUUC-Opu-083710 Oryza punctata 65.43 0.00e+00 729.00
IUUC-Oru-084250 Oryza rufipogon 65.23 0.00e+00 728.00
IUUC-Osa-085363 Oryza sativa 65.23 0.00e+00 728.00
IUUC-Ola-087092 Oryzias latipes 94.74 0.00e+00 1026.00
IUUC-Olu-087753 Ostreococcus lucimarinus 50.39 2.00e-140 493.00
IUUC-Oga-088278 Otolemur garnettii 91.31 0.00e+00 957.00
IUUC-Oar-089664 Ovis aries 99.42 0.00e+00 1066.00
IUUC-Ptr-090991 Pan troglodytes 100.00 0.00e+00 1071.00
IUUC-Pan-092697 Papio anubis 100.00 0.00e+00 1071.00
IUUC-Psi-093204 Pelodiscus sinensis 100.00 0.00e+00 1045.00
IUUC-Ppa-095325 Physcomitrella patens 66.02 0.00e+00 738.00
IUUC-Pfo-096988 Poecilia formosa 94.93 0.00e+00 1034.00
IUUC-Pab-098288 Pongo abelii 100.00 0.00e+00 1071.00
IUUC-Pop-098787 Populus trichocarpa 66.28 0.00e+00 739.00
IUUC-Pca-100583 Procavia capensis 93.06 0.00e+00 957.00
IUUC-Ppe-101307 Prunus persica 65.43 0.00e+00 731.00
IUUC-Pva-102711 Pteropus vampyrus 100.00 0.00e+00 1071.00
IUUC-Rno-105614 Rattus norvegicus 100.00 0.00e+00 1071.00
IUUC-Sha-107017 Sarcophilus harrisii 99.81 0.00e+00 1071.00
IUUC-Smo-109547 Selaginella moellendorffii 63.55 0.00e+00 677.00
IUUC-Sit-110278 Setaria italica 65.23 0.00e+00 708.00
IUUC-Sly-111777 Solanum lycopersicum 67.19 0.00e+00 740.00
IUUC-Stu-112293 Solanum tuberosum 66.99 0.00e+00 738.00
IUUC-Sar-112955 Sorex araneus 89.88 0.00e+00 947.00
IUUC-Sbi-114802 Sorghum bicolor 65.43 0.00e+00 703.00
IUUC-Ssc-116054 Sus scrofa 100.00 0.00e+00 1071.00
IUUC-Tgu-116909 Taeniopygia guttata 98.44 0.00e+00 1056.00
IUUC-Tru-118195 Takifugu rubripes 94.54 0.00e+00 1030.00
IUUC-Tsy-119420 Tarsius syrichta 92.20 0.00e+00 969.00
IUUC-Tni-120416 Tetraodon nigroviridis 94.15 0.00e+00 1024.00
IUUC-Tca-121653 Theobroma cacao 66.28 0.00e+00 712.00
IUUC-Tae-125609 Triticum aestivum 64.65 0.00e+00 725.00
IUUC-Tur-126197 Triticum urartu 66.12 3.00e-155 540.00
IUUC-Tbe-128009 Tupaia belangeri 100.00 0.00e+00 716.00
IUUC-Ttr-128719 Tursiops truncatus 91.42 0.00e+00 964.00
IUUC-Vpa-130579 Vicugna pacos 99.61 0.00e+00 1063.00
IUUC-Vvi-131127 Vitis vinifera 66.99 0.00e+00 739.00
IUUC-Xtr-132950 Xenopus tropicalis 91.88 0.00e+00 978.00
IUUC-Xma-133537 Xiphophorus maculatus 94.93 0.00e+00 1034.00
Created Date 25-Jun-2017

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