iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027573

Ensembl Protein ID

ENSDARP00000128178.1

UniProt Accession

X1WD81; X1WD81_DANRE

Genbank Protein ID

ENSDARP00000128178

Protein Name

WD40 repeat domain 95

Genbank Nucleotide ID

AL929092

Gene Name

wdr95

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000054572.5	ENSDART00000154456.2	ENSDARP00000128178.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.20e-31	105.8	608	642
UBD/Beta-Prp	2.50e-46	159.1	465	747

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgv 34
           gH++++ c+a   + +ll++Gs Dg i vW++ +g+
   Q: 608  GHKEDILCIAHctP-HLLATGSFDGEIIVWNVVSGR 642
           8********97544.99***************9997 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk..g 92
           +hk+++ c  +s++ +++++ s+ + ik+wdv+tg l+ ++     ++++t+++f+ +g  l+tg++D++ik+w++++g+cv +l+  g
   Q: 465  SHKEPVLCCGYSEQFRQVVSCSEGSVIKIWDVETGALIFEFgcAHGDSAITCMTFDTSGRRLMTGGRDGLIKLWNFNNGQCVKILSreG 553
           46666777899999999********************888886677789************************************9889 PP
   S: 93   hedsvlslsfsp.sg.dklvsGshdrtirvwdletgqclee...........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlkt 168
           +  +++++s+    g  +++s ++ r i ++ l+++++ +            + +gh++ + c++ h++  ll++Gs D+ + +W++ +
   Q: 554  KCPEICDCSYLTlHGnTFVISVGWSRRIDIY-LDSKEETQFiqrptpswqddMRNGHKEDILCIA-HCTPHLLATGSFDGEIIVWNVVS 640
           999*********96669999**********9.333333333469*******************96.7878******************* PP
   S: 169  gkllrtltgghtdsvyslsfdsng...................kelvsgsldgtvklwdlq.tgecvrtlnght..dnvksvrfspnde 235
           g++  +++  + +++ s  ++ ++                     lvs +  g+v++w++   g+ v ++++    ++++ ++++++d 
   Q: 641  GRIQCRFQTPQSQKISSSHVQNTSvlsliflktrafvpelassAWLVSSGSRGYVNFWSVLnGGKFVASFQASHlqQQITKLALTQDDS 729
           *******988999999999888888888888888999999*99****************9956788999999655599*********** PP
   S: 236  rlvsgssDgsiriWdlrs 253
            l ++ + g i+++++++
   Q: 730  MLFTADHVGFIYVYNVKQ 747
           ***************986 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MVSINDLKHI KQAFDEFAKA GIDMLDYAEF QTVMRSCPSL KTVKDTQIQH LFMKIDYTGD 60
GKIEWHEICT YIFLENKKKE ETVHRSKMAA FVLPAIVKFL NCGEPLLRIH FPPNGTVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCATAAA CAGACCCCAG ATTGAAAACT ACATCAACTT TAGGTATGTT ACAGGGTGTG 60
AATTTATCTT TTAATATCTT TTATATTCTC CTAAACATGA TAAATTAGTA GACAAGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50222--EF_HAND_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005509--F:calcium ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001921	Ailuropoda melanoleuca	49.61	5.00e-153	534.00
IUUC-Apl-003630	Anas platyrhynchos	28.82	7.00e-21	95.90
IUUC-Aca-005140	Anolis carolinensis	26.98	1.00e-70	261.00
IUUC-Ame-011582	Astyanax mexicanus	56.23	0.00e+00	744.00
IUUC-Bta-013034	Bos taurus	47.25	2.00e-142	499.00
IUUC-Cja-020006	Callithrix jacchus	26.69	7.00e-61	228.00
IUUC-Csa-023945	Chlorocebus sabaeus	23.78	1.00e-31	132.00
IUUC-Cin-025633	Ciona intestinalis	42.15	1.00e-98	353.00
IUUC-Csv-026326	Ciona savignyi	40.94	7.00e-125	441.00
IUUC-Dno-030073	Dasypus novemcinctus	40.60	4.00e-161	561.00
IUUC-Dor-030182	Dipodomys ordii	30.52	1.00e-48	188.00
IUUC-Dme-031984	Drosophila melanogaster	22.10	4.00e-42	167.00
IUUC-Ete-033152	Echinops telfairi	29.21	6.00e-54	205.00
IUUC-Eca-033354	Equus caballus	47.11	1.00e-144	506.00
IUUC-Fca-036185	Felis catus	44.23	3.00e-134	472.00
IUUC-Fal-037351	Ficedula albicollis	24.47	1.00e-39	158.00
IUUC-Gmo-039551	Gadus morhua	61.41	9.00e-111	394.00
IUUC-Gga-041212	Gallus gallus	24.19	4.00e-35	144.00
IUUC-Gac-041482	Gasterosteus aculeatus	56.18	3.00e-174	604.00
IUUC-Ggo-044932	Gorilla gorilla	27.81	4.00e-60	227.00
IUUC-Hsa-046963	Homo sapiens	27.17	3.00e-60	227.00
IUUC-Itr-049019	Ictidomys tridecemlineatus	47.05	5.00e-152	531.00
IUUC-Lch-050242	Latimeria chalumnae	53.61	0.00e+00	715.00
IUUC-Loc-052710	Lepisosteus oculatus	56.96	0.00e+00	788.00
IUUC-Laf-054050	Loxodonta africana	27.85	4.00e-44	173.00
IUUC-Mcc-054635	Macaca mulatta	26.89	5.00e-60	226.00
IUUC-Meu-056792	Macropus eugenii	26.48	3.00e-35	143.00
IUUC-Mga-060077	Meleagris gallopavo	20.94	3.00e-13	70.90
IUUC-Mmr-061370	Microcebus murinus	26.24	3.00e-59	224.00
IUUC-Mdo-062347	Monodelphis domestica	49.12	0.00e+00	686.00
IUUC-Mmu-063878	Mus musculus	40.77	1.00e-174	606.00
IUUC-Nle-069533	Nomascus leucogenys	29.07	3.00e-50	193.00
IUUC-Opr-070439	Ochotona princeps	25.09	9.00e-32	132.00
IUUC-Ont-071688	Oreochromis niloticus	54.64	9.00e-163	566.00
IUUC-Oan-072752	Ornithorhynchus anatinus	48.30	1.00e-133	469.00
IUUC-Ocu-074780	Oryctolagus cuniculus	37.86	6.00e-57	214.00
IUUC-Ola-086449	Oryzias latipes	53.44	2.00e-150	525.00
IUUC-Oar-090438	Ovis aries	27.38	6.00e-69	256.00
IUUC-Ptr-090859	Pan troglodytes	28.04	2.00e-52	200.00
IUUC-Pan-092049	Papio anubis	27.21	2.00e-35	143.00
IUUC-Psi-093625	Pelodiscus sinensis	32.15	3.00e-65	243.00
IUUC-Pma-094599	Petromyzon marinus	48.68	2.00e-153	535.00
IUUC-Ppa-095538	Physcomitrella patens	30.14	5.00e-19	89.70
IUUC-Pfo-096408	Poecilia formosa	50.93	0.00e+00	677.00
IUUC-Pab-098444	Pongo abelii	29.89	2.00e-46	180.00
IUUC-Pca-100863	Procavia capensis	24.16	2.00e-23	105.00
IUUC-Pva-102863	Pteropus vampyrus	28.92	2.00e-54	207.00
IUUC-Rno-105331	Rattus norvegicus	43.66	7.00e-131	461.00
IUUC-Sha-106832	Sarcophilus harrisii	49.03	2.00e-151	529.00
IUUC-Smo-109247	Selaginella moellendorffii	25.52	2.00e-54	208.00
IUUC-Sar-113119	Sorex araneus	28.25	3.00e-21	97.10
IUUC-Ssc-116310	Sus scrofa	46.91	8.00e-146	510.00
IUUC-Tru-117666	Takifugu rubripes	52.86	4.00e-162	564.00
IUUC-Tsy-119608	Tarsius syrichta	27.17	1.00e-45	178.00
IUUC-Tni-120449	Tetraodon nigroviridis	26.71	1.00e-33	137.00
IUUC-Tbe-127509	Tupaia belangeri	27.97	4.00e-46	179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence