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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105332
Ensembl Protein ID ENSRNOP00000009893.5
UniProt Accession D3ZYG0; D3ZYG0_RAT
Genbank Protein ID ENSRNOP00000009893
Protein Name Vav guanine nucleotide exchange factor 2
Genbank Nucleotide ID AABR07051353
Gene Name Vav2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007422.6 ENSRNOT00000009893.6 ENSRNOP00000009893.5
ENSRNOG00000007422.6 ENSRNOT00000081376.1 ENSRNOP00000075062.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.10e-18 64.7 813 864
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 813  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 864
           67**********************************..9*************86 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105332|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGTGGGGCG AGTAGCTCAG GCGCCGGACG CAGGGACCGA GCGACCCGCT GCGCCTTTGT 60
CTCGGGTGGG GCAGGAGCGG CGGCCGGAGC GGGGCGCCCC GAACGCAGAA TGCGGCGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105332|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
KEGG rno:296603
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001437 Ailuropoda melanoleuca 92.45 0.00e+00 1457.00
IUUC-Apl-003262 Anas platyrhynchos 89.98 0.00e+00 1545.00
IUUC-Aca-004628 Anolis carolinensis 65.81 0.00e+00 919.00
IUUC-Ath-007352 Arabidopsis thaliana 34.38 8.00e-04 39.30
IUUC-Ame-011608 Astyanax mexicanus 78.91 0.00e+00 1418.00
IUUC-Bta-013147 Bos taurus 92.35 0.00e+00 1309.00
IUUC-Cel-018578 Caenorhabditis elegans 27.48 5.00e-95 342.00
IUUC-Cja-018877 Callithrix jacchus 90.63 0.00e+00 1394.00
IUUC-Cfa-020315 Canis familiaris 90.80 0.00e+00 1237.00
IUUC-Cpo-021543 Cavia porcellus 93.96 0.00e+00 1350.00
IUUC-Csa-024204 Chlorocebus sabaeus 91.96 0.00e+00 1598.00
IUUC-Cin-025115 Ciona intestinalis 36.21 1.00e-144 507.00
IUUC-Csv-025995 Ciona savignyi 37.12 1.00e-151 530.00
IUUC-Dre-028308 Danio rerio 80.75 0.00e+00 1447.00
IUUC-Dno-029584 Dasypus novemcinctus 87.18 0.00e+00 1140.00
IUUC-Dor-031014 Dipodomys ordii 82.70 0.00e+00 1221.00
IUUC-Eca-033448 Equus caballus 91.23 0.00e+00 1568.00
IUUC-Eeu-035182 Erinaceus europaeus 82.54 0.00e+00 663.00
IUUC-Fca-035460 Felis catus 92.45 0.00e+00 1322.00
IUUC-Fal-036684 Ficedula albicollis 88.79 0.00e+00 1551.00
IUUC-Gmo-038816 Gadus morhua 75.00 0.00e+00 1102.00
IUUC-Gga-040999 Gallus gallus 88.25 0.00e+00 1529.00
IUUC-Gac-041353 Gasterosteus aculeatus 76.69 0.00e+00 1159.00
IUUC-Ggo-044558 Gorilla gorilla 93.85 0.00e+00 1606.00
IUUC-Hsa-046208 Homo sapiens 93.96 0.00e+00 1609.00
IUUC-Itr-047931 Ictidomys tridecemlineatus 90.79 0.00e+00 1212.00
IUUC-Loc-052827 Lepisosteus oculatus 80.18 0.00e+00 1465.00
IUUC-Laf-054009 Loxodonta africana 91.48 0.00e+00 1556.00
IUUC-Mcc-055054 Macaca mulatta 93.85 0.00e+00 1607.00
IUUC-Meu-056269 Macropus eugenii 84.38 0.00e+00 752.00
IUUC-Mga-060106 Meleagris gallopavo 90.90 0.00e+00 1558.00
IUUC-Mmr-061118 Microcebus murinus 92.63 0.00e+00 1580.00
IUUC-Mdo-062380 Monodelphis domestica 87.24 0.00e+00 1281.00
IUUC-Mmu-063135 Mus musculus 97.93 0.00e+00 1685.00
IUUC-Mpu-066135 Mustela putorius furo 89.86 0.00e+00 1433.00
IUUC-Nle-069465 Nomascus leucogenys 87.29 0.00e+00 1471.00
IUUC-Ont-071945 Oreochromis niloticus 81.64 0.00e+00 1431.00
IUUC-Oan-073384 Ornithorhynchus anatinus 87.43 0.00e+00 1215.00
IUUC-Ola-087499 Oryzias latipes 76.91 0.00e+00 1092.00
IUUC-Oga-088444 Otolemur garnettii 90.03 0.00e+00 1287.00
IUUC-Oar-089576 Ovis aries 87.35 0.00e+00 1214.00
IUUC-Ptr-090507 Pan troglodytes 95.05 0.00e+00 1615.00
IUUC-Pan-092325 Papio anubis 91.71 0.00e+00 1559.00
IUUC-Psi-094021 Pelodiscus sinensis 88.00 0.00e+00 1511.00
IUUC-Pma-094372 Petromyzon marinus 54.32 0.00e+00 718.00
IUUC-Pfo-096732 Poecilia formosa 81.43 0.00e+00 1439.00
IUUC-Pab-098426 Pongo abelii 77.67 0.00e+00 1146.00
IUUC-Pca-100295 Procavia capensis 91.89 0.00e+00 1470.00
IUUC-Sha-106529 Sarcophilus harrisii 91.46 0.00e+00 1253.00
IUUC-Ssc-116176 Sus scrofa 92.44 0.00e+00 1441.00
IUUC-Tgu-116917 Taeniopygia guttata 90.39 0.00e+00 1420.00
IUUC-Tru-118398 Takifugu rubripes 79.11 0.00e+00 1010.00
IUUC-Tni-120819 Tetraodon nigroviridis 79.63 0.00e+00 1224.00
IUUC-Xtr-132747 Xenopus tropicalis 79.17 0.00e+00 1367.00
Created Date 25-Jun-2017

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