iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118419

UUCD1 version

UUC-TaR-00366

Ensembl Protein ID

ENSTRUP00000018335.1

UniProt Accession

H2T0Z7; H2T0Z7_TAKRU

Protein Name

Uncharacterized protein

Gene Name

hectd3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000007419.1	ENSTRUT00000018411.1	ENSTRUP00000018335.1
ENSTRUG00000007419.1	ENSTRUT00000018412.1	ENSTRUP00000018336.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-73	248.0	521	845

Active Site

Position(s)	Description	Evidence
815	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f +++n+    + ++d ++ np  +++  Fe++G+l+g al+ + +l
   Q: 521  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSaecampLPFFCRTSNQ--GAFEARDYYVPNPscKEFHKFEWIGQLMGAALRGKDFL 607
           356*****************************98888777777665554..4456777777777779999******************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeY 173
            l l+  ++k+l g+ +++ +d+++vd+ l+++l+ ++++     ++++++++f    v +++l++ + +eL+pgG+ni+V +e+++++
   Q: 608  VLALPGLVWKQLTGEAVHWnKDFPAVDSVLVNFLEAMEHM-----DKETFEFRFGedlVYTTLLSDGQMVELIPGGSNISVCYEDRSKF 691
           **************************************77.....555677777755667778************************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  k+q++a+++G+ +v+p+ +l+l+t++e e  +cG++ei+v++lk+ t y++ +++++  +q++we+l +f++e+r+
   Q: 692  IHLVQKARLEE-SKQQITAMQAGLLKVVPQAVLDLLTWQEAEKKVCGDPEISVDALKRLTHYED-LEPSNIRVQYLWEALTNFTNEDRS 778
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+F+Tg+srlP+       p  +   k  ++++d lP+s+TC ++L LP+Y+s ++++ekL+yA  ++ +++
   Q: 779  RFLRFITGRSRLPA-------PIYIFPDKqgSETTDALPQSSTCSSTLYLPNYPSAKVCEEKLRYAAYNCVAID 845
           *************5.......44466666788888*********************************998776 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

IIMCNNPHLL LGRIRFLNRC IECLKRSESM PESLCYIPKE VCYKVCKDSS FTTSASSGVP 60
AGGAKTLIPV FDIPLQTPHI KKLCKYNIEL KKGTCIRTTG EQYRNSQGLW VKITKEQMEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCATCATGT GTAACAATCC TCATCTGCTA CTCGGCAGGA TCCGTTTTTT GAACAGGTGT 60
ATTGAGTGTT TGAAAAGGAG TGAGTCGATG CCAGAGTCGC TGTGTTATAT TCCCAAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	67.21	0.00e+00	1199.00
IUUC-Apl-003715	Anas platyrhynchos	77.06	0.00e+00	1178.00
IUUC-Aca-004377	Anolis carolinensis	71.50	0.00e+00	1248.00
IUUC-Ame-011918	Astyanax mexicanus	75.35	0.00e+00	1321.00
IUUC-Bta-012736	Bos taurus	68.02	0.00e+00	1211.00
IUUC-Cja-019926	Callithrix jacchus	68.02	0.00e+00	1211.00
IUUC-Cfa-020753	Canis familiaris	76.95	0.00e+00	954.00
IUUC-Cpo-021415	Cavia porcellus	67.67	0.00e+00	1205.00
IUUC-Csa-023096	Chlorocebus sabaeus	67.55	0.00e+00	1206.00
IUUC-Dre-028746	Danio rerio	82.73	0.00e+00	1416.00
IUUC-Dno-029293	Dasypus novemcinctus	77.97	0.00e+00	880.00
IUUC-Dor-031113	Dipodomys ordii	77.48	0.00e+00	1003.00
IUUC-Ete-032601	Echinops telfairi	67.31	0.00e+00	1053.00
IUUC-Eca-034198	Equus caballus	66.67	0.00e+00	1192.00
IUUC-Eeu-034708	Erinaceus europaeus	79.46	0.00e+00	754.00
IUUC-Fca-035478	Felis catus	68.30	0.00e+00	1199.00
IUUC-Fal-037366	Ficedula albicollis	71.30	0.00e+00	1228.00
IUUC-Gmo-039020	Gadus morhua	85.63	0.00e+00	1160.00
IUUC-Gga-040332	Gallus gallus	73.14	0.00e+00	1265.00
IUUC-Gac-042336	Gasterosteus aculeatus	86.42	0.00e+00	1517.00
IUUC-Ggo-045382	Gorilla gorilla	67.55	0.00e+00	1206.00
IUUC-Hsa-046562	Homo sapiens	67.55	0.00e+00	1206.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	67.67	0.00e+00	1204.00
IUUC-Lch-049606	Latimeria chalumnae	71.03	0.00e+00	665.00
IUUC-Loc-052448	Lepisosteus oculatus	69.50	0.00e+00	1186.00
IUUC-Laf-054507	Loxodonta africana	67.36	0.00e+00	1209.00
IUUC-Mcc-055690	Macaca mulatta	67.55	0.00e+00	1205.00
IUUC-Meu-055970	Macropus eugenii	68.07	0.00e+00	1177.00
IUUC-Mga-059654	Meleagris gallopavo	77.53	0.00e+00	1162.00
IUUC-Mmr-061069	Microcebus murinus	67.79	0.00e+00	1206.00
IUUC-Mdo-062547	Monodelphis domestica	79.67	0.00e+00	701.00
IUUC-Mmu-063096	Mus musculus	67.67	0.00e+00	1206.00
IUUC-Mpu-065846	Mustela putorius furo	67.67	0.00e+00	1209.00
IUUC-Mlu-067992	Myotis lucifugus	72.30	0.00e+00	1170.00
IUUC-Nle-069565	Nomascus leucogenys	66.13	0.00e+00	1110.00
IUUC-Opr-070853	Ochotona princeps	65.06	0.00e+00	800.00
IUUC-Ont-071628	Oreochromis niloticus	86.67	0.00e+00	1483.00
IUUC-Ocu-074094	Oryctolagus cuniculus	67.79	0.00e+00	1207.00
IUUC-Ola-087384	Oryzias latipes	85.26	0.00e+00	1495.00
IUUC-Oga-088224	Otolemur garnettii	67.67	0.00e+00	1209.00
IUUC-Oar-090043	Ovis aries	66.82	0.00e+00	1153.00
IUUC-Ptr-090852	Pan troglodytes	67.32	0.00e+00	1197.00
IUUC-Pan-092787	Papio anubis	67.55	0.00e+00	1205.00
IUUC-Psi-092986	Pelodiscus sinensis	66.67	0.00e+00	882.00
IUUC-Pma-094416	Petromyzon marinus	38.60	1.00e-168	586.00
IUUC-Pfo-096720	Poecilia formosa	86.10	0.00e+00	1514.00
IUUC-Pab-098325	Pongo abelii	61.67	0.00e+00	879.00
IUUC-Pca-100885	Procavia capensis	62.76	0.00e+00	907.00
IUUC-Pva-102829	Pteropus vampyrus	55.50	0.00e+00	700.00
IUUC-Rno-104882	Rattus norvegicus	67.67	0.00e+00	1206.00
IUUC-Sha-106811	Sarcophilus harrisii	75.94	1.00e-98	353.00
IUUC-Sar-113020	Sorex araneus	69.29	2.00e-171	596.00
IUUC-Ssc-115436	Sus scrofa	65.93	1.00e-105	376.00
IUUC-Tgu-117042	Taeniopygia guttata	73.03	0.00e+00	1270.00
IUUC-Tsy-118829	Tarsius syrichta	68.53	0.00e+00	709.00
IUUC-Tni-120410	Tetraodon nigroviridis	81.85	0.00e+00	1292.00
IUUC-Tbe-128113	Tupaia belangeri	79.06	0.00e+00	642.00
IUUC-Ttr-128167	Tursiops truncatus	64.13	0.00e+00	1122.00
IUUC-Xtr-132910	Xenopus tropicalis	63.15	0.00e+00	1032.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence