iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118497

UUCD1 version

UUC-TaR-00381

Ensembl Protein ID

ENSTRUP00000018762.1

UniProt Accession

H2T274; H2T274_TAKRU

Protein Name

Uncharacterized protein

Gene Name

SMURF2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000007571.1	ENSTRUT00000018840.1	ENSTRUP00000018762.1
ENSTRUG00000007571.1	ENSTRUT00000018841.1	ENSTRUP00000018763.1
ENSTRUG00000007571.1	ENSTRUT00000018842.1	ENSTRUP00000018764.1
ENSTRUG00000007571.1	ENSTRUT00000018843.1	ENSTRUP00000018765.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-126	423.8	427	759

Active Site

Position(s)	Description	Evidence
728	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+y+ +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 427  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYTRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 514
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+ly+sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++i+V ++ k+eYv+l+v+
   Q: 515  GFTLPFYKQLLGKSITLDDMESVDPDLYNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKTISVSEDTKKEYVRLYVN 599
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 600  WRFLHGIEAQFLALQKGFNEVIPQHLLKSFDEKELELIVCGLGKIDISDWKANTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 687
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da++++lP+++TCfn++++P+Y+ +++l++kLl+Aieet gF +
   Q: 688  TGSSRVPLQGFKALQgaagPRLFTIHQiDANTNNLPKAHTCFNRIDIPPYEGYDKLYDKLLTAIEETCGFAV 759
           ***************************99999**************************************76 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MSSQGVRRND PVKLRLTVLC AKNLSKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KADSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLIDT GYQRLDLNKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTAGCC AAGGAGTTAG GAGAAATGAC CCAGTCAAGC TGCGGTTGAC AGGTAAGCCA 60
CTTTTATTTA CTCCTCTCCT GGTGTAAGGG TTAGCAGGGT GGCTTAATAG CCAGCCAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	88.89	0.00e+00	1373.00
IUUC-Apl-003513	Anas platyrhynchos	90.32	0.00e+00	1392.00
IUUC-Aca-005358	Anolis carolinensis	90.53	0.00e+00	1410.00
IUUC-Ame-011320	Astyanax mexicanus	88.70	0.00e+00	1413.00
IUUC-Bta-013399	Bos taurus	89.10	0.00e+00	1372.00
IUUC-Cja-019355	Callithrix jacchus	89.30	0.00e+00	1380.00
IUUC-Cpo-022200	Cavia porcellus	89.13	0.00e+00	1375.00
IUUC-Cin-025126	Ciona intestinalis	63.82	0.00e+00	954.00
IUUC-Csv-026339	Ciona savignyi	62.76	0.00e+00	989.00
IUUC-Dre-027650	Danio rerio	90.69	0.00e+00	1449.00
IUUC-Dno-029534	Dasypus novemcinctus	88.82	0.00e+00	1392.00
IUUC-Ete-032715	Echinops telfairi	84.64	0.00e+00	1283.00
IUUC-Eca-033580	Equus caballus	89.26	0.00e+00	1375.00
IUUC-Eeu-034945	Erinaceus europaeus	88.15	0.00e+00	1281.00
IUUC-Fal-037275	Ficedula albicollis	89.99	0.00e+00	1390.00
IUUC-Gga-041060	Gallus gallus	86.58	0.00e+00	1340.00
IUUC-Gac-041983	Gasterosteus aculeatus	94.98	0.00e+00	1503.00
IUUC-Hsa-046726	Homo sapiens	89.08	0.00e+00	1393.00
IUUC-Lch-050026	Latimeria chalumnae	90.26	0.00e+00	1399.00
IUUC-Loc-051760	Lepisosteus oculatus	86.37	0.00e+00	1359.00
IUUC-Laf-053753	Loxodonta africana	89.38	0.00e+00	1375.00
IUUC-Mcc-054815	Macaca mulatta	89.08	0.00e+00	1393.00
IUUC-Mmr-060806	Microcebus murinus	88.99	0.00e+00	1372.00
IUUC-Mdo-062805	Monodelphis domestica	89.21	0.00e+00	1396.00
IUUC-Mmu-064034	Mus musculus	89.34	0.00e+00	1396.00
IUUC-Mpu-066762	Mustela putorius furo	89.02	0.00e+00	1376.00
IUUC-Mlu-066981	Myotis lucifugus	89.11	0.00e+00	1372.00
IUUC-Nle-069804	Nomascus leucogenys	89.29	0.00e+00	1390.00
IUUC-Opr-070591	Ochotona princeps	84.50	0.00e+00	1278.00
IUUC-Ont-072243	Oreochromis niloticus	93.69	0.00e+00	1514.00
IUUC-Oan-072699	Ornithorhynchus anatinus	87.34	0.00e+00	1394.00
IUUC-Ocu-074913	Oryctolagus cuniculus	88.95	0.00e+00	1394.00
IUUC-Ola-087161	Oryzias latipes	87.35	0.00e+00	1283.00
IUUC-Oga-089116	Otolemur garnettii	86.02	0.00e+00	1314.00
IUUC-Oar-089366	Ovis aries	88.86	0.00e+00	1371.00
IUUC-Ptr-091382	Pan troglodytes	89.08	0.00e+00	1393.00
IUUC-Psi-093298	Pelodiscus sinensis	89.78	0.00e+00	1371.00
IUUC-Pma-094354	Petromyzon marinus	72.02	0.00e+00	1110.00
IUUC-Pfo-096142	Poecilia formosa	92.84	0.00e+00	1447.00
IUUC-Pab-098682	Pongo abelii	89.08	0.00e+00	1394.00
IUUC-Pva-102754	Pteropus vampyrus	88.01	0.00e+00	1335.00
IUUC-Rno-105600	Rattus norvegicus	88.89	0.00e+00	1184.00
IUUC-Sha-107144	Sarcophilus harrisii	88.89	0.00e+00	1265.00
IUUC-Sar-113122	Sorex araneus	78.71	0.00e+00	1161.00
IUUC-Tgu-117112	Taeniopygia guttata	89.21	0.00e+00	1400.00
IUUC-Tni-120781	Tetraodon nigroviridis	98.46	0.00e+00	1296.00
IUUC-Tbe-127371	Tupaia belangeri	79.89	0.00e+00	1112.00
IUUC-Ttr-129305	Tursiops truncatus	83.22	0.00e+00	1184.00
IUUC-Vpa-130591	Vicugna pacos	79.78	0.00e+00	1186.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence