iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013488

Ensembl Protein ID

ENSBTAP00000005130.5

UniProt Accession

Q2T9V9; PHF10_BOVIN

Genbank Protein ID

AAI11244.1

Protein Name

PHD finger protein 10; BRG1-associated factor 45a

Genbank Nucleotide ID

BC111243

Gene Name

PHF10; BAF45A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003929.5	ENSBTAT00000005130.5	ENSBTAP00000005130.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.90e-13	49.9	346	392

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C +Cg+++++e +++ C+ C++ +H  C++l      p+   wiC  C++
   Q: 346  KTCIICGQPHHEE-EMMFCDVCDRGYHTFCVGLG---AIPSGR-WICDCCQR 392
           78*********88.5*******************...999996.******86 PP

Organism

Bos taurus

Functional Description
(View)

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Protein Sequence
(Fasta)

MLQEQVSEYL GVTSFKRKYP DLERRDLSHK EKLYLRELNV ITETQCTLGL TALRSDEVID 60
LMIKEYPAKH AEYSVILQEK ERQRITDHYK EYSQMQQQNT QKVEASKVPE YIKKAAKKAA 120

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Nucleotide Sequence
(Fasta)

ATGCTTCAAG AACAAGTCAG TGAATATTTG GGTGTGACCT CCTTTAAACG GAAATATCCA 60
GGTATTAAGT CTCAGTTTAT ATAACAAATT AAATCTAACT TTTAACTAAT AGTAATTGTT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD

SMART

SM00249--PHD

Gene Ontology

GO:0071564--C:npBAF complex
GO:0008270--F:zinc ion binding
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

bta:507648

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001967	Ailuropoda melanoleuca	95.12	0.00e+00	724.00
IUUC-Atr-003066	Amborella trichopoda	44.00	7.00e-09	55.80
IUUC-Apl-003184	Anas platyrhynchos	86.97	0.00e+00	676.00
IUUC-Aca-005357	Anolis carolinensis	84.15	0.00e+00	643.00
IUUC-Afl-008743	Aspergillus flavus	47.73	9.00e-10	58.90
IUUC-Ani-009406	Aspergillus nidulans	42.59	7.00e-09	55.80
IUUC-Aor-009922	Aspergillus oryzae	47.73	7.00e-10	58.90
IUUC-Ame-011482	Astyanax mexicanus	88.60	2.00e-90	326.00
IUUC-Cel-018612	Caenorhabditis elegans	31.99	5.00e-56	211.00
IUUC-Cja-018959	Callithrix jacchus	92.93	0.00e+00	710.00
IUUC-Cfa-020275	Canis familiaris	95.61	0.00e+00	726.00
IUUC-Cpo-021997	Cavia porcellus	93.17	0.00e+00	718.00
IUUC-Csa-024058	Chlorocebus sabaeus	93.17	0.00e+00	708.00
IUUC-Cin-025585	Ciona intestinalis	53.27	2.00e-55	210.00
IUUC-Csv-026176	Ciona savignyi	51.26	3.00e-52	199.00
IUUC-Dre-027911	Danio rerio	69.62	3.00e-148	518.00
IUUC-Dno-028846	Dasypus novemcinctus	93.17	0.00e+00	711.00
IUUC-Dor-030929	Dipodomys ordii	92.20	0.00e+00	702.00
IUUC-Dme-032114	Drosophila melanogaster	31.49	2.00e-28	122.00
IUUC-Ete-032648	Echinops telfairi	96.65	1.00e-91	329.00
IUUC-Eca-034382	Equus caballus	94.88	0.00e+00	723.00
IUUC-Eeu-035027	Erinaceus europaeus	93.90	0.00e+00	720.00
IUUC-Fca-036040	Felis catus	93.17	0.00e+00	705.00
IUUC-Fal-037535	Ficedula albicollis	88.54	0.00e+00	665.00
IUUC-Fso-038253	Fusarium solani	48.84	4.00e-09	56.60
IUUC-Gmo-038527	Gadus morhua	70.49	1.00e-148	519.00
IUUC-Gga-040769	Gallus gallus	98.45	1.00e-102	366.00
IUUC-Gac-042584	Gasterosteus aculeatus	70.22	1.00e-151	529.00
IUUC-Ggo-045145	Gorilla gorilla	92.70	0.00e+00	704.00
IUUC-Hsa-047029	Homo sapiens	93.17	0.00e+00	707.00
IUUC-Itr-047896	Ictidomys tridecemlineatus	93.41	0.00e+00	709.00
IUUC-Lch-050598	Latimeria chalumnae	66.16	6.00e-145	507.00
IUUC-Loc-052902	Lepisosteus oculatus	78.59	2.00e-167	582.00
IUUC-Laf-053764	Loxodonta africana	90.07	0.00e+00	651.00
IUUC-Mcc-055088	Macaca mulatta	92.93	0.00e+00	705.00
IUUC-Meu-056586	Macropus eugenii	91.34	6.00e-65	241.00
IUUC-Mga-059912	Meleagris gallopavo	80.78	1.00e-170	592.00
IUUC-Mmr-061508	Microcebus murinus	93.41	0.00e+00	711.00
IUUC-Mdo-062561	Monodelphis domestica	91.95	0.00e+00	672.00
IUUC-Mmu-063445	Mus musculus	92.20	0.00e+00	704.00
IUUC-Mpu-066775	Mustela putorius furo	94.88	0.00e+00	726.00
IUUC-Mlu-067747	Myotis lucifugus	93.92	0.00e+00	712.00
IUUC-Nle-069553	Nomascus leucogenys	93.17	0.00e+00	708.00
IUUC-Opr-071037	Ochotona princeps	70.00	2.00e-72	264.00
IUUC-Ont-072137	Oreochromis niloticus	71.96	1.00e-149	523.00
IUUC-Oan-073733	Ornithorhynchus anatinus	91.95	0.00e+00	694.00
IUUC-Ocu-074802	Oryctolagus cuniculus	91.95	0.00e+00	671.00
IUUC-Ola-086309	Oryzias latipes	72.82	7.00e-149	520.00
IUUC-Oga-088663	Otolemur garnettii	92.48	0.00e+00	706.00
IUUC-Oar-089478	Ovis aries	95.39	0.00e+00	689.00
IUUC-Ptr-091474	Pan troglodytes	93.17	0.00e+00	708.00
IUUC-Pan-092456	Papio anubis	92.94	0.00e+00	702.00
IUUC-Psi-093676	Pelodiscus sinensis	90.00	0.00e+00	678.00
IUUC-Pfo-096908	Poecilia formosa	73.21	2.00e-148	518.00
IUUC-Pab-097820	Pongo abelii	92.68	0.00e+00	705.00
IUUC-Pca-100174	Procavia capensis	88.59	0.00e+00	651.00
IUUC-Pva-102571	Pteropus vampyrus	83.41	1.00e-172	598.00
IUUC-Rno-105400	Rattus norvegicus	92.44	0.00e+00	708.00
IUUC-Sha-107024	Sarcophilus harrisii	91.97	0.00e+00	669.00
IUUC-Ssc-115799	Sus scrofa	92.46	0.00e+00	648.00
IUUC-Tgu-116658	Taeniopygia guttata	89.02	0.00e+00	671.00
IUUC-Tru-118269	Takifugu rubripes	65.54	1.00e-139	489.00
IUUC-Tsy-119389	Tarsius syrichta	92.44	0.00e+00	665.00
IUUC-Tni-119914	Tetraodon nigroviridis	71.53	3.00e-143	501.00
IUUC-Tbe-128154	Tupaia belangeri	79.08	0.00e+00	642.00
IUUC-Ttr-129016	Tursiops truncatus	95.84	0.00e+00	692.00
IUUC-Xtr-132371	Xenopus tropicalis	72.07	3.00e-153	534.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence