iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033301

UUCD1 version

UUC-EqC-00602

Ensembl Protein ID

ENSECAP00000011666.1

UniProt Accession

F6ZS96; F6ZS96_HORSE

Protein Name

E3 ubiquitin-protein ligase Mdm2

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000013604.1	ENSECAT00000014580.1	ENSECAP00000011666.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.77	0.00e+00	730.00	IUUC-Hsa-046376
E3 activity/RING/RING	71.57	1.00e-166	583.00	IUUC-Mmu-063207
E3 activity/RING/RING	74.29	1.00e-180	629.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

FPALRQMCNT NMSVSTDGAV STAQIPAAEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVI 60
FYLGQYIMTK RLYDERQQHM VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY RNLVVVNQPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCTGCTC TTAGGCAGAT GTGCAATACC AACATGTCTG TGTCCACTGA TGGTGCAGTA 60
AGCACCGCGC AGATCCCAGC TGCGGAGCAG GAGACCCTGG TTGGTATTTC TGTCTCAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	83.67	0.00e+00	735.00
IUUC-Apl-003193	Anas platyrhynchos	59.35	2.00e-143	502.00
IUUC-Aca-004305	Anolis carolinensis	55.82	1.00e-113	403.00
IUUC-Ame-010675	Astyanax mexicanus	44.29	1.00e-82	300.00
IUUC-Bta-013270	Bos taurus	81.91	0.00e+00	697.00
IUUC-Cja-019744	Callithrix jacchus	81.74	0.00e+00	694.00
IUUC-Cfa-020807	Canis familiaris	82.35	0.00e+00	660.00
IUUC-Cpo-022182	Cavia porcellus	79.27	0.00e+00	651.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	34.62	3.00e-04	36.20
IUUC-Csa-023541	Chlorocebus sabaeus	83.71	0.00e+00	719.00
IUUC-Cho-024831	Choloepus hoffmanni	69.49	6.00e-85	306.00
IUUC-Csv-026151	Ciona savignyi	31.17	1.00e-10	60.10
IUUC-Dre-028419	Danio rerio	46.10	2.00e-50	192.00
IUUC-Dno-028950	Dasypus novemcinctus	82.11	0.00e+00	712.00
IUUC-Dor-031048	Dipodomys ordii	62.55	5.00e-143	501.00
IUUC-Ete-032264	Echinops telfairi	63.89	5.00e-153	533.00
IUUC-Eeu-035005	Erinaceus europaeus	72.71	1.00e-160	559.00
IUUC-Fca-035454	Felis catus	83.50	0.00e+00	692.00
IUUC-Fal-036720	Ficedula albicollis	57.81	7.00e-71	260.00
IUUC-Gmo-039296	Gadus morhua	72.73	5.00e-26	111.00
IUUC-Gga-040251	Gallus gallus	60.00	2.00e-138	485.00
IUUC-Gac-041528	Gasterosteus aculeatus	41.95	3.00e-35	142.00
IUUC-Ggo-044948	Gorilla gorilla	75.97	0.00e+00	630.00
IUUC-Hsa-046376	Homo sapiens	83.77	0.00e+00	723.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	79.48	0.00e+00	669.00
IUUC-Lch-050037	Latimeria chalumnae	53.33	7.00e-110	390.00
IUUC-Loc-051837	Lepisosteus oculatus	48.80	2.00e-111	395.00
IUUC-Laf-053483	Loxodonta africana	78.05	0.00e+00	665.00
IUUC-Mcc-055294	Macaca mulatta	83.57	0.00e+00	722.00
IUUC-Mga-060007	Meleagris gallopavo	58.81	7.00e-128	450.00
IUUC-Mmr-060673	Microcebus murinus	82.08	0.00e+00	716.00
IUUC-Mdo-063057	Monodelphis domestica	67.21	6.00e-170	590.00
IUUC-Mmu-063207	Mus musculus	69.29	5.00e-159	553.00
IUUC-Mpu-065836	Mustela putorius furo	83.30	0.00e+00	719.00
IUUC-Mlu-068193	Myotis lucifugus	78.92	0.00e+00	670.00
IUUC-Nle-069927	Nomascus leucogenys	83.57	0.00e+00	722.00
IUUC-Opr-070590	Ochotona princeps	75.97	1.00e-173	602.00
IUUC-Ont-071984	Oreochromis niloticus	39.48	3.00e-71	262.00
IUUC-Oan-072744	Ornithorhynchus anatinus	65.61	3.00e-148	518.00
IUUC-Ocu-074071	Oryctolagus cuniculus	81.78	0.00e+00	670.00
IUUC-Ola-087329	Oryzias latipes	39.40	4.00e-45	175.00
IUUC-Oga-088135	Otolemur garnettii	73.94	0.00e+00	647.00
IUUC-Oar-089726	Ovis aries	81.76	0.00e+00	732.00
IUUC-Ptr-091399	Pan troglodytes	83.77	0.00e+00	723.00
IUUC-Pan-092720	Papio anubis	83.57	0.00e+00	722.00
IUUC-Psi-093591	Pelodiscus sinensis	60.22	4.00e-120	424.00
IUUC-Pma-094500	Petromyzon marinus	67.92	5.00e-19	87.40
IUUC-Pfo-096316	Poecilia formosa	40.87	6.00e-69	254.00
IUUC-Pab-097696	Pongo abelii	83.16	0.00e+00	716.00
IUUC-Pca-100974	Procavia capensis	76.72	0.00e+00	696.00
IUUC-Pva-102488	Pteropus vampyrus	77.85	0.00e+00	628.00
IUUC-Rno-105641	Rattus norvegicus	74.29	1.00e-172	599.00
IUUC-Sha-107314	Sarcophilus harrisii	66.80	1.00e-178	619.00
IUUC-Sar-112938	Sorex araneus	76.53	0.00e+00	672.00
IUUC-Ssc-115495	Sus scrofa	82.08	0.00e+00	689.00
IUUC-Tgu-116623	Taeniopygia guttata	59.56	1.00e-135	476.00
IUUC-Tru-117820	Takifugu rubripes	40.43	1.00e-70	259.00
IUUC-Tsy-119162	Tarsius syrichta	57.30	3.00e-70	258.00
IUUC-Tbe-127816	Tupaia belangeri	61.17	2.00e-88	319.00
IUUC-Ttr-129194	Tursiops truncatus	83.63	1.00e-147	516.00
IUUC-Vpa-130326	Vicugna pacos	76.27	5.00e-177	613.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence