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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031893
Ensembl Protein ID FBpp0113022
UniProt Accession Q7KU86; A8E6X7; URM1_DROME
Genbank Protein ID AAS65063.2; ABV82301.1
Protein Name Ubiquitin-related modifier 1 homolog
Genbank Nucleotide ID AE014296; BT030919
Gene Name CG33276
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0053276 FBtr0114530 FBpp0113022
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 36.73 9.00e-16 76.30 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MGTPELKIIL EFSAGAELLF GNIKRRELNL DGKQKWTIAN LLKWMHANIL TERPELFLQG 60
DTVRPGILVL INDTDWELLG ELDYELQPND NVLFISTLHG G 101
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Protein Fasta Sequence


>IUUC-Dme-031893|ULD,UBQ_Other|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
ATATGATGGG CACGCCGGAA TTAAAAATCA TATTAGAATT CAGGTATATA AAGCCTTGTT 60
CGAATTATTA TTTCCAATAA ATGAGACAAT TTGTAATTTA ATTTCGTAGT GCAGGGGCGG 120
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Nucleotide Fasta Sequence


>IUUC-Dme-031893|ULD,UBQ_Other|Drosophila melanogaster
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0046329--P:negative regulation of JNK cascade
GO:0034227--P:tRNA thio-modification
KEGG dme:Dmel_CG33276
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 63.73 7.00e-33 130.00
IUUC-Atr-003089 Amborella trichopoda 51.52 5.00e-26 108.00
IUUC-Apl-003382 Anas platyrhynchos 65.93 2.00e-31 125.00
IUUC-Aca-004981 Anolis carolinensis 59.80 4.00e-31 125.00
IUUC-Aly-005517 Arabidopsis lyrata 50.00 2.00e-23 99.40
IUUC-Ath-006718 Arabidopsis thaliana 60.00 2.00e-21 92.40
IUUC-Ago-007917 Ashbya gossypii 38.38 9.00e-18 80.50
IUUC-Acl-008054 Aspergillus clavatus 66.00 2.00e-15 72.80
IUUC-Afl-008704 Aspergillus flavus 50.56 5.00e-20 87.80
IUUC-Aor-009890 Aspergillus oryzae 49.50 2.00e-23 99.80
IUUC-Bta-012448 Bos taurus 61.76 2.00e-32 129.00
IUUC-Bci-013865 Botrytis cinerea 48.11 3.00e-22 95.50
IUUC-Bdi-014980 Brachypodium distachyon 58.67 2.00e-22 96.30
IUUC-Bol-016055 Brassica oleracea 50.62 2.00e-21 92.80
IUUC-Bra-016845 Brassica rapa 50.62 2.00e-21 92.80
IUUC-Cel-018485 Caenorhabditis elegans 35.00 2.00e-11 59.30
IUUC-Cja-019587 Callithrix jacchus 63.73 7.00e-33 130.00
IUUC-Cfa-020653 Canis familiaris 60.78 4.00e-32 128.00
IUUC-Cpo-021622 Cavia porcellus 63.73 7.00e-33 130.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.54 1.00e-24 103.00
IUUC-Csa-023756 Chlorocebus sabaeus 52.04 1.00e-22 98.20
IUUC-Cgl-026518 Colletotrichum gloeosporioides 46.60 8.00e-20 87.80
IUUC-Cne-026953 Cryptococcus neoformans 45.79 1.00e-21 94.40
IUUC-Cme-027314 Cyanidioschyzon merolae 43.16 3.00e-17 79.00
IUUC-Dre-027884 Danio rerio 62.75 2.00e-31 125.00
IUUC-Dno-029262 Dasypus novemcinctus 59.26 3.00e-21 93.60
IUUC-Dor-030601 Dipodomys ordii 68.75 7.00e-18 80.90
IUUC-Ete-032773 Echinops telfairi 60.78 4.00e-31 124.00
IUUC-Eca-034187 Equus caballus 62.75 1.00e-32 130.00
IUUC-Eeu-034808 Erinaceus europaeus 60.78 1.00e-31 126.00
IUUC-Fca-036107 Felis catus 63.73 4.00e-33 131.00
IUUC-Fal-036607 Ficedula albicollis 64.84 1.00e-30 122.00
IUUC-Fox-037698 Fusarium oxysporum 48.11 4.00e-21 92.00
IUUC-Gmo-039492 Gadus morhua 58.82 2.00e-29 119.00
IUUC-Ggr-039965 Gaeumannomyces graminis 48.08 7.00e-21 92.00
IUUC-Gga-041268 Gallus gallus 61.76 3.00e-32 128.00
IUUC-Gac-042111 Gasterosteus aculeatus 60.78 1.00e-31 126.00
IUUC-Gma-043240 Glycine max 56.34 1.00e-21 93.20
IUUC-Ggo-045176 Gorilla gorilla 52.58 4.00e-17 79.30
IUUC-Hsa-046077 Homo sapiens 64.71 5.00e-28 114.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 68.54 3.00e-26 108.00
IUUC-Kpa-049157 Komagataella pastoris 40.82 3.00e-16 75.50
IUUC-Lch-049889 Latimeria chalumnae 60.78 3.00e-30 122.00
IUUC-Lpe-050783 Leersia perrieri 60.56 6.00e-23 97.80
IUUC-Loc-052400 Lepisosteus oculatus 59.80 2.00e-30 122.00
IUUC-Lma-053259 Leptosphaeria maculans 45.28 6.00e-20 88.20
IUUC-Laf-053596 Loxodonta africana 62.50 2.00e-31 125.00
IUUC-Mcc-054845 Macaca mulatta 68.54 4.00e-31 124.00
IUUC-Meu-055968 Macropus eugenii 60.78 9.00e-32 127.00
IUUC-Mor-057126 Magnaporthe oryzae 48.08 5.00e-21 92.40
IUUC-Mpo-057311 Magnaporthe poae 48.08 1.00e-21 94.40
IUUC-Mtr-058266 Medicago truncatula 59.70 3.00e-21 92.00
IUUC-Mla-058847 Melampsora laricipopulina 36.89 4.00e-10 55.80
IUUC-Mga-059468 Meleagris gallopavo 65.93 3.00e-31 125.00
IUUC-Mvi-060235 Microbotryum violaceum 71.43 5.00e-16 75.90
IUUC-Mdo-061948 Monodelphis domestica 58.82 5.00e-31 124.00
IUUC-Mmu-063946 Mus musculus 62.75 2.00e-32 129.00
IUUC-Mac-064812 Musa acuminata 62.86 5.00e-24 101.00
IUUC-Mpu-066763 Mustela putorius furo 61.76 2.00e-32 129.00
IUUC-Mlu-066970 Myotis lucifugus 58.75 6.00e-22 94.00
IUUC-Ncr-068824 Neurospora crassa 44.55 4.00e-19 85.10
IUUC-Nle-069849 Nomascus leucogenys 52.04 6.00e-22 95.50
IUUC-Opr-070227 Ochotona princeps 63.73 7.00e-33 130.00
IUUC-Ont-072530 Oreochromis niloticus 61.22 5.00e-31 124.00
IUUC-Oan-073191 Ornithorhynchus anatinus 61.80 2.00e-28 115.00
IUUC-Ocu-074460 Oryctolagus cuniculus 63.92 1.00e-32 129.00
IUUC-Oba-075499 Oryza barthii 61.97 4.00e-22 96.30
IUUC-Obr-076896 Oryza brachyantha 58.57 1.00e-20 92.40
IUUC-Ogl-077834 Oryza glaberrima 61.97 1.00e-22 96.70
IUUC-Ogu-078622 Oryza glumaepatula 61.97 1.00e-22 96.70
IUUC-Oin-079358 Oryza indica 61.97 4.00e-22 96.70
IUUC-Olo-081035 Oryza longistaminata 61.97 2.00e-22 97.40
IUUC-Oni-082425 Oryza nivara 61.97 1.00e-22 96.70
IUUC-Opu-083461 Oryza punctata 61.43 9.00e-22 95.10
IUUC-Oru-084875 Oryza rufipogon 57.75 2.00e-19 85.50
IUUC-Oga-089128 Otolemur garnettii 62.75 2.00e-32 129.00
IUUC-Oar-089896 Ovis aries 61.76 2.00e-32 129.00
IUUC-Ptr-091618 Pan troglodytes 52.58 4.00e-17 79.30
IUUC-Pan-092238 Papio anubis 52.04 3.00e-22 96.70
IUUC-Psi-093879 Pelodiscus sinensis 63.73 3.00e-33 132.00
IUUC-Pma-094484 Petromyzon marinus 64.56 7.00e-25 103.00
IUUC-Ppa-095801 Physcomitrella patens 54.93 3.00e-20 88.60
IUUC-Pfo-097192 Poecilia formosa 58.82 5.00e-30 121.00
IUUC-Pab-098203 Pongo abelii 64.71 5.00e-28 114.00
IUUC-Pop-099614 Populus trichocarpa 59.70 2.00e-21 92.40
IUUC-Pca-100507 Procavia capensis 57.50 7.00e-22 94.00
IUUC-Ppe-101174 Prunus persica 50.51 2.00e-26 109.00
IUUC-Pva-102735 Pteropus vampyrus 62.75 3.00e-29 118.00
IUUC-Pgr-103510 Puccinia graminis 38.78 3.00e-10 56.20
IUUC-Ptt-103918 Puccinia triticina 39.80 7.00e-12 61.60
IUUC-Pte-104173 Pyrenophora teres 47.52 3.00e-22 95.50
IUUC-Pyt-104806 Pyrenophora triticirepentis 48.51 3.00e-22 95.90
IUUC-Rno-105820 Rattus norvegicus 62.75 1.00e-32 129.00
IUUC-Sce-106366 Saccharomyces cerevisiae 36.73 2.00e-16 76.30
IUUC-Sja-107727 Schizosaccharomyces japonicus 43.88 5.00e-17 78.60
IUUC-Spo-108074 Schizosaccharomyces pombe 42.42 8.00e-11 57.40
IUUC-Smo-108944 Selaginella moellendorffii 54.55 1.00e-23 99.80
IUUC-Sit-110277 Setaria italica 61.11 3.00e-23 99.00
IUUC-Sly-111505 Solanum lycopersicum 54.22 2.00e-24 102.00
IUUC-Stu-112076 Solanum tuberosum 54.22 2.00e-24 102.00
IUUC-Sbi-114274 Sorghum bicolor 59.15 1.00e-22 97.10
IUUC-Sre-114953 Sporisorium reilianum 50.48 2.00e-21 93.20
IUUC-Ssc-115418 Sus scrofa 61.76 2.00e-32 129.00
IUUC-Tgu-117311 Taeniopygia guttata 65.93 8.00e-31 123.00
IUUC-Tru-118598 Takifugu rubripes 62.22 8.00e-29 117.00
IUUC-Tni-120109 Tetraodon nigroviridis 57.28 7.00e-28 114.00
IUUC-Tca-120942 Theobroma cacao 50.60 2.00e-21 92.80
IUUC-Tre-122099 Trichoderma reesei 50.00 6.00e-15 71.20
IUUC-Tvi-122285 Trichoderma virens 47.62 2.00e-16 76.30
IUUC-Tae-125193 Triticum aestivum 60.56 1.00e-22 96.70
IUUC-Tur-126677 Triticum urartu 51.81 5.00e-20 88.60
IUUC-Tme-127120 Tuber melanosporum 45.36 1.00e-18 84.00
IUUC-Tbe-128050 Tupaia belangeri 46.08 3.00e-18 82.40
IUUC-Ttr-129019 Tursiops truncatus 60.40 1.00e-31 126.00
IUUC-Uma-129483 Ustilago maydis 47.66 2.00e-20 90.10
IUUC-Vda-129690 Verticillium dahliae 37.50 2.00e-14 70.10
IUUC-Vvi-131174 Vitis vinifera 53.01 1.00e-23 99.80
IUUC-Xma-133862 Xiphophorus maculatus 58.82 5.00e-30 121.00
IUUC-Yli-134398 Yarrowia lipolytica 43.43 6.00e-17 77.80
IUUC-Zma-134964 Zea mays 61.97 2.00e-22 95.90
Created Date 25-Jun-2017

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