iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016784.1	ENSONIT00000021167.1	ENSONIP00000021148.1
ENSONIG00000016784.1	ENSONIT00000021168.1	ENSONIP00000021149.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-120	403.0	1221	1553

Active Site

Position(s)	Description	Evidence
1521	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgE+gld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al+++ lld
   Q: 1221 DLQRSKLYVSFVGEDGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALVHQYLLD 1306
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG+ ipV ++Nk+eY+++
   Q: 1307 AFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGAGIPVSEKNKKEYIER 1389
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+++q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1390 MVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1476
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ekL +A+eet+ F+l+
   Q: 1477 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKLVTAVEETSTFGLE 1553
           **************************************************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

LSVGGREHLS APRRRSPHLR HTLSPENLRT LAERGGAAVD TVSVVSSPIG LPRANSDTDL 60
VTSQSRSSLT ASTLEYTLNR GQNLVISWDI KEEVDATDWI GLYHIDETSP SNVWDCKNRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCGAAGAT CATGAAACTG GTGAAACTTG ACCATCACAA AACCCAAAGC GATGTGCACG 60
AGGACCTGCA GGTGTAACAG GTGCGTCTGT CTACGAGAAA ATGATTGGTC GACAGATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	64.70	0.00e+00	1902.00
IUUC-Aca-004558	Anolis carolinensis	64.85	0.00e+00	1881.00
IUUC-Dno-029963	Dasypus novemcinctus	62.70	0.00e+00	1774.00
IUUC-Dor-031030	Dipodomys ordii	67.36	0.00e+00	749.00
IUUC-Fca-036157	Felis catus	80.80	0.00e+00	1350.00
IUUC-Gmo-039291	Gadus morhua	69.91	0.00e+00	1294.00
IUUC-Gac-042456	Gasterosteus aculeatus	84.58	0.00e+00	2518.00
IUUC-Mdo-063017	Monodelphis domestica	64.53	0.00e+00	1886.00
IUUC-Nle-069308	Nomascus leucogenys	84.51	0.00e+00	1360.00
IUUC-Ola-087225	Oryzias latipes	91.67	0.00e+00	1484.00
IUUC-Ptr-090806	Pan troglodytes	63.79	0.00e+00	1893.00
IUUC-Rno-105943	Rattus norvegicus	64.09	0.00e+00	1898.00
IUUC-Tru-118706	Takifugu rubripes	93.83	0.00e+00	1502.00
IUUC-Tni-120069	Tetraodon nigroviridis	78.56	0.00e+00	1501.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence