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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064271
UUCD1 version UUC-MuM-01054
Ensembl Protein ID ENSMUSP00000013338.8
UniProt Accession Q9Z1K6; ARI2_MOUSE
Genbank Protein ID AAD24573.1; CAA10273.1; AAH51998.1; AAH52422.1
Protein Name E3 ubiquitin-protein ligase ARIH2; RING-type E3 ubiquitin transferase ARIH2; Triad1 protein; UbcM4-interacting protein 48
Genbank Nucleotide ID AF124664; AJ130975; BC051998; BC052422
Gene Name Arih2; Ari2; Triad1; Uip48
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000064145.12 ENSMUST00000013338.13 ENSMUSP00000013338.8
ENSMUSG00000064145.12 ENSMUST00000193190.5 ENSMUSP00000141914.1
ENSMUSG00000064145.12 ENSMUST00000194073.5 ENSMUSP00000141364.1
ENSMUSG00000064145.12 ENSMUST00000193643.1 ENSMUSP00000141369.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RBR 4.40e-55 187.3 138 325
Active Site
Position(s) Description Evidence
309 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC+ ++  +e++ +l+C+h+fC++C++q++++ +k+g  + isc+a++cp +++e+ +  ll++eel ++y+++l++++ve++ +l++
   Q: 138  CAVCM-QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQL 226
           9***9.77777888899************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp +dC +v+++++  ++ +v+c++c+++fC++C++++H++++C +++++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 227  CPGADCPMVIRVQEP-RARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCA---DDSETANYISAHTKDCPKCNICIEKNGGCNHM 312
           **************7.99*************************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C+kCk++fCw+C
   Q: 313  QCSKCKHDFCWMC 325
           ************* PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis (By similarity).
 E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis (By similarity).
Protein Sequence
(Fasta)
MSVDMNSQGS DSNEEDYDPN CEEEEEEEED PGDIEDYYVG VASDVEQQGA DAFDPEEYQF 60
TCLTYKESEG ALHEHMTSLA SVLKVSHSVA KLILVNFHWQ VSEILDRYRS NSAQLLVEAR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064271|E3,RBR|Mus musculus
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Nucleotide Sequence
(Fasta)
GGAGCTGCGG GGGACGGCTC TGCCGGAGGA AGCTGCGCGG GCCTGAGCCG CGTCCGCCGG 60
CTGCCTCCGC TGCCGCTACG CCTCCGTCAG CCTGGTTTGG TCTGGCTTGA CCTGGTCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064271|E3,RBR|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048588--P:developmental cell growth
GO:0071425--P:hematopoietic stem cell proliferation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:23807
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001557 Ailuropoda melanoleuca 97.56 0.00e+00 932.00
IUUC-Atr-002495 Amborella trichopoda 32.27 4.00e-51 196.00
IUUC-Apl-003878 Anas platyrhynchos 92.28 0.00e+00 870.00
IUUC-Aca-004865 Anolis carolinensis 91.87 0.00e+00 877.00
IUUC-Bta-012901 Bos taurus 97.36 0.00e+00 927.00
IUUC-Bra-017081 Brassica rapa 28.74 8.00e-58 218.00
IUUC-Cel-018334 Caenorhabditis elegans 49.09 9.00e-127 447.00
IUUC-Cja-019728 Callithrix jacchus 97.97 0.00e+00 933.00
IUUC-Cfa-020953 Canis familiaris 97.76 0.00e+00 932.00
IUUC-Cpo-021445 Cavia porcellus 98.17 0.00e+00 936.00
IUUC-Csa-023769 Chlorocebus sabaeus 96.15 0.00e+00 930.00
IUUC-Cho-024650 Choloepus hoffmanni 85.80 0.00e+00 783.00
IUUC-Cin-025577 Ciona intestinalis 54.09 5.00e-143 501.00
IUUC-Csv-025849 Ciona savignyi 55.84 6.00e-120 423.00
IUUC-Dre-028490 Danio rerio 80.00 0.00e+00 780.00
IUUC-Dno-029942 Dasypus novemcinctus 96.15 0.00e+00 924.00
IUUC-Dor-030134 Dipodomys ordii 84.03 6.00e-150 523.00
IUUC-Dme-031853 Drosophila melanogaster 55.70 4.00e-150 524.00
IUUC-Ete-032355 Echinops telfairi 88.46 0.00e+00 830.00
IUUC-Eca-033440 Equus caballus 97.76 0.00e+00 932.00
IUUC-Eeu-035230 Erinaceus europaeus 88.94 9.00e-115 406.00
IUUC-Fca-036308 Felis catus 91.48 0.00e+00 859.00
IUUC-Fal-036974 Ficedula albicollis 92.28 0.00e+00 870.00
IUUC-Gmo-038642 Gadus morhua 81.31 0.00e+00 786.00
IUUC-Gga-041019 Gallus gallus 92.28 0.00e+00 870.00
IUUC-Gac-042014 Gasterosteus aculeatus 80.28 0.00e+00 804.00
IUUC-Ggo-045329 Gorilla gorilla 96.55 0.00e+00 931.00
IUUC-Hsa-046712 Homo sapiens 96.96 0.00e+00 931.00
IUUC-Itr-048370 Ictidomys tridecemlineatus 98.08 0.00e+00 838.00
IUUC-Lch-049584 Latimeria chalumnae 85.40 0.00e+00 822.00
IUUC-Loc-051826 Lepisosteus oculatus 80.98 3.00e-168 584.00
IUUC-Laf-054567 Loxodonta africana 96.34 0.00e+00 926.00
IUUC-Mcc-054919 Macaca mulatta 96.15 0.00e+00 930.00
IUUC-Meu-056332 Macropus eugenii 88.44 0.00e+00 839.00
IUUC-Mga-060132 Meleagris gallopavo 92.51 0.00e+00 875.00
IUUC-Mmr-061599 Microcebus murinus 92.31 0.00e+00 874.00
IUUC-Mdo-062186 Monodelphis domestica 93.96 0.00e+00 797.00
IUUC-Mpu-066827 Mustela putorius furo 95.95 0.00e+00 824.00
IUUC-Mlu-067528 Myotis lucifugus 96.95 0.00e+00 889.00
IUUC-Nle-068995 Nomascus leucogenys 96.55 0.00e+00 931.00
IUUC-Opr-070518 Ochotona princeps 95.54 0.00e+00 890.00
IUUC-Ont-071650 Oreochromis niloticus 83.27 0.00e+00 824.00
IUUC-Oan-073676 Ornithorhynchus anatinus 92.89 0.00e+00 749.00
IUUC-Ocu-073761 Oryctolagus cuniculus 96.96 0.00e+00 934.00
IUUC-Obr-076705 Oryza brachyantha 29.82 3.00e-58 219.00
IUUC-Ola-087204 Oryzias latipes 80.16 0.00e+00 799.00
IUUC-Oga-088098 Otolemur garnettii 96.15 0.00e+00 925.00
IUUC-Oar-089205 Ovis aries 97.36 0.00e+00 927.00
IUUC-Ptr-091514 Pan troglodytes 96.55 0.00e+00 931.00
IUUC-Pan-092493 Papio anubis 91.45 0.00e+00 884.00
IUUC-Psi-093024 Pelodiscus sinensis 86.67 3.00e-116 410.00
IUUC-Pfo-097256 Poecilia formosa 82.44 0.00e+00 816.00
IUUC-Pab-098504 Pongo abelii 88.84 0.00e+00 831.00
IUUC-Pca-100700 Procavia capensis 89.25 0.00e+00 830.00
IUUC-Pva-103105 Pteropus vampyrus 96.75 0.00e+00 917.00
IUUC-Rno-105289 Rattus norvegicus 98.98 0.00e+00 940.00
IUUC-Sha-107417 Sarcophilus harrisii 92.29 0.00e+00 860.00
IUUC-Sar-113042 Sorex araneus 95.37 0.00e+00 919.00
IUUC-Ssc-115362 Sus scrofa 97.56 0.00e+00 930.00
IUUC-Tgu-117469 Taeniopygia guttata 91.90 0.00e+00 822.00
IUUC-Tru-117976 Takifugu rubripes 80.98 0.00e+00 821.00
IUUC-Tsy-118876 Tarsius syrichta 84.55 4.00e-94 338.00
IUUC-Tni-119831 Tetraodon nigroviridis 80.78 0.00e+00 798.00
IUUC-Tca-121326 Theobroma cacao 29.60 1.00e-60 227.00
IUUC-Tbe-127386 Tupaia belangeri 88.44 1.00e-157 549.00
IUUC-Ttr-128315 Tursiops truncatus 97.36 0.00e+00 928.00
IUUC-Vpa-130383 Vicugna pacos 90.45 0.00e+00 834.00
IUUC-Xtr-132945 Xenopus tropicalis 90.45 0.00e+00 874.00
Created Date 25-Jun-2017

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