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Tag Content
UUCD2 ID IUUC-Sha-107010
UUCD1 version UUC-SaH-00652
Ensembl Protein ID ENSSHAP00000015733.1
UniProt Accession G3WJX8; G3WJX8_SARHA
Genbank Protein ID ENSSHAP00000015733
Protein Name Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH alpha
Genbank Nucleotide ID AEFK01178223
Gene Name PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000013409.1 ENSSHAT00000015861.1 ENSSHAP00000015733.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.10e-60 196.2 190 229
UBD/Beta-Prp 1.40e-93 313.5 105 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 190  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 229
           899*******99777********************99875 PP
   

   UBD/Beta-Prp
   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           +g h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+
   Q: 105  SG-HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHD 192
           44.5568888******************************************************************************* PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           ++v s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v
   Q: 193  HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVV 279
           ************************************.*********************************************9.***** PP
   S: 184  yslsfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
           +++s+ +++                    + l+sgs+d+t+k+wd+ tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++
   Q: 280  ECISWAPESsyssiseatgsetkksskpgPILLSGSRDKTIKMWDVITGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
           ******999999***************************************************************************** PP
   S: 253  sgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 369  NKRCMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           ********************.99*****************985 PP
   
Organism Sarcophilus harrisii
Functional Description
(View)

Functional Description


     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYSLSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107010|E3,WD_repeat;UBD,Beta-Prp|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGAATGAG CCTTCCTTGT TGAATGTCTC CTCGTTACCT GTTGGATCTC TCCTGTGAAG 60
AACTATTTTC CCAATAGTGG ACGCCACTTT GTGGCACATT TGATTTCTGA TTCAGGGATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107010|E3,WD_repeat;UBD,Beta-Prp|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0031965--C:nuclear membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0016042--P:lipid catabolic process
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule
KEGG shr:100929845
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 99.00 0.00e+00 826.00
IUUC-Apl-004024 Anas platyrhynchos 97.80 0.00e+00 842.00
IUUC-Aca-004564 Anolis carolinensis 97.56 0.00e+00 837.00
IUUC-Ago-007862 Ashbya gossypii 27.23 2.00e-38 153.00
IUUC-Acl-008360 Aspergillus clavatus 46.29 1.00e-103 370.00
IUUC-Afl-008502 Aspergillus flavus 45.69 6.00e-94 337.00
IUUC-Afu-008848 Aspergillus fumigatus 46.78 1.00e-105 376.00
IUUC-Ani-009173 Aspergillus nidulans 42.29 8.00e-90 323.00
IUUC-Ang-009873 Aspergillus niger 44.30 1.00e-93 336.00
IUUC-Aor-009973 Aspergillus oryzae 43.94 9.00e-92 330.00
IUUC-Ate-010523 Aspergillus terreus 41.81 2.00e-90 325.00
IUUC-Ame-010969 Astyanax mexicanus 93.90 0.00e+00 813.00
IUUC-Bgr-011972 Blumeria graminis 47.49 3.00e-105 375.00
IUUC-Bta-013106 Bos taurus 99.02 0.00e+00 849.00
IUUC-Bci-013615 Botrytis cinerea 44.82 9.00e-99 353.00
IUUC-Cel-018459 Caenorhabditis elegans 57.66 1.00e-148 519.00
IUUC-Cja-018755 Callithrix jacchus 96.59 0.00e+00 828.00
IUUC-Cfa-020749 Canis familiaris 99.02 0.00e+00 849.00
IUUC-Cpo-022371 Cavia porcellus 99.02 0.00e+00 849.00
IUUC-Csa-023524 Chlorocebus sabaeus 98.26 0.00e+00 712.00
IUUC-Cho-024764 Choloepus hoffmanni 88.95 0.00e+00 679.00
IUUC-Cin-025753 Ciona intestinalis 70.32 7.00e-179 619.00
IUUC-Csv-025817 Ciona savignyi 68.78 0.00e+00 629.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 46.57 4.00e-97 348.00
IUUC-Cne-027087 Cryptococcus neoformans 50.39 1.00e-110 392.00
IUUC-Dre-027554 Danio rerio 93.66 0.00e+00 807.00
IUUC-Dno-029050 Dasypus novemcinctus 98.78 0.00e+00 848.00
IUUC-Dor-030222 Dipodomys ordii 91.46 0.00e+00 773.00
IUUC-Dse-031164 Dothistroma septosporum 43.38 3.00e-101 362.00
IUUC-Dme-031745 Drosophila melanogaster 69.83 4.00e-171 593.00
IUUC-Ete-032508 Echinops telfairi 98.56 7.00e-167 579.00
IUUC-Eca-034288 Equus caballus 98.50 0.00e+00 822.00
IUUC-Eeu-034984 Erinaceus europaeus 91.22 0.00e+00 769.00
IUUC-Fca-036498 Felis catus 99.02 0.00e+00 849.00
IUUC-Fal-036920 Ficedula albicollis 97.80 0.00e+00 842.00
IUUC-Fox-037996 Fusarium oxysporum 46.41 5.00e-104 371.00
IUUC-Fso-038160 Fusarium solani 43.87 2.00e-98 352.00
IUUC-Gmo-038983 Gadus morhua 93.41 0.00e+00 805.00
IUUC-Ggr-040051 Gaeumannomyces graminis 44.87 2.00e-97 348.00
IUUC-Gga-040623 Gallus gallus 97.80 0.00e+00 842.00
IUUC-Gac-041613 Gasterosteus aculeatus 91.95 0.00e+00 799.00
IUUC-Ggo-045410 Gorilla gorilla 88.47 0.00e+00 719.00
IUUC-Hsa-046358 Homo sapiens 98.78 0.00e+00 847.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 99.02 0.00e+00 849.00
IUUC-Kpa-049351 Komagataella pastoris 29.37 1.00e-42 167.00
IUUC-Lch-049936 Latimeria chalumnae 95.85 0.00e+00 825.00
IUUC-Loc-052476 Lepisosteus oculatus 94.99 0.00e+00 796.00
IUUC-Lma-053170 Leptosphaeria maculans 46.43 1.00e-100 359.00
IUUC-Laf-053713 Loxodonta africana 97.07 0.00e+00 829.00
IUUC-Mcc-054628 Macaca mulatta 98.54 0.00e+00 845.00
IUUC-Meu-055927 Macropus eugenii 87.36 4.00e-142 496.00
IUUC-Mor-056962 Magnaporthe oryzae 45.08 3.00e-98 352.00
IUUC-Mpo-057583 Magnaporthe poae 44.63 2.00e-93 335.00
IUUC-Mla-058819 Melampsora laricipopulina 48.31 8.00e-119 420.00
IUUC-Mga-059945 Meleagris gallopavo 97.56 0.00e+00 841.00
IUUC-Mvi-060403 Microbotryum violaceum 50.11 2.00e-128 452.00
IUUC-Mmr-061289 Microcebus murinus 99.00 0.00e+00 826.00
IUUC-Mdo-061912 Monodelphis domestica 99.76 0.00e+00 855.00
IUUC-Mmu-063253 Mus musculus 99.02 0.00e+00 849.00
IUUC-Mpu-066638 Mustela putorius furo 99.02 0.00e+00 849.00
IUUC-Mlu-067267 Myotis lucifugus 97.30 0.00e+00 830.00
IUUC-Nfi-068571 Neosartorya fischeri 45.07 9.00e-98 350.00
IUUC-Ncr-068895 Neurospora crassa 48.17 2.00e-105 375.00
IUUC-Nle-069087 Nomascus leucogenys 98.51 0.00e+00 689.00
IUUC-Opr-070579 Ochotona princeps 98.78 0.00e+00 848.00
IUUC-Ont-072432 Oreochromis niloticus 93.66 0.00e+00 812.00
IUUC-Oan-073072 Ornithorhynchus anatinus 99.02 0.00e+00 849.00
IUUC-Ocu-074180 Oryctolagus cuniculus 98.78 0.00e+00 848.00
IUUC-Ola-086772 Oryzias latipes 93.17 0.00e+00 804.00
IUUC-Oga-088219 Otolemur garnettii 96.82 0.00e+00 828.00
IUUC-Oar-090394 Ovis aries 99.02 0.00e+00 849.00
IUUC-Ptr-091517 Pan troglodytes 99.02 0.00e+00 849.00
IUUC-Pan-092421 Papio anubis 98.54 0.00e+00 845.00
IUUC-Psi-093370 Pelodiscus sinensis 98.05 0.00e+00 843.00
IUUC-Pma-094319 Petromyzon marinus 87.97 0.00e+00 638.00
IUUC-Pno-094815 Phaeosphaeria nodorum 47.02 4.00e-104 371.00
IUUC-Pfo-097089 Poecilia formosa 92.68 0.00e+00 805.00
IUUC-Pab-098421 Pongo abelii 99.02 0.00e+00 849.00
IUUC-Pca-100120 Procavia capensis 72.03 7.00e-162 563.00
IUUC-Pva-102960 Pteropus vampyrus 98.78 0.00e+00 845.00
IUUC-Pgr-103538 Puccinia graminis 47.87 2.00e-118 419.00
IUUC-Ptt-103990 Puccinia triticina 42.68 1.00e-44 174.00
IUUC-Pte-104261 Pyrenophora teres 47.49 2.00e-104 372.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.73 7.00e-105 374.00
IUUC-Rno-105123 Rattus norvegicus 99.02 0.00e+00 849.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.34 6.00e-65 241.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.95 2.00e-99 355.00
IUUC-Sar-113309 Sorex araneus 98.25 0.00e+00 816.00
IUUC-Sre-115003 Sporisorium reilianum 49.77 2.00e-124 439.00
IUUC-Ssc-116148 Sus scrofa 99.02 0.00e+00 849.00
IUUC-Tgu-117299 Taeniopygia guttata 97.56 0.00e+00 839.00
IUUC-Tru-118179 Takifugu rubripes 91.22 0.00e+00 799.00
IUUC-Tsy-119493 Tarsius syrichta 97.56 0.00e+00 832.00
IUUC-Tni-120355 Tetraodon nigroviridis 92.20 0.00e+00 776.00
IUUC-Tre-121977 Trichoderma reesei 43.22 4.00e-101 361.00
IUUC-Tvi-122661 Trichoderma virens 43.44 1.00e-99 356.00
IUUC-Tme-127031 Tuber melanosporum 47.99 8.00e-103 367.00
IUUC-Tbe-127492 Tupaia belangeri 81.92 2.00e-113 402.00
IUUC-Ttr-128929 Tursiops truncatus 98.78 0.00e+00 845.00
IUUC-Uma-129347 Ustilago maydis 47.95 5.00e-123 434.00
IUUC-Vda-129837 Verticillium dahliae 45.19 8.00e-99 353.00
IUUC-Vpa-130532 Vicugna pacos 85.23 0.00e+00 664.00
IUUC-Xtr-131985 Xenopus tropicalis 96.59 0.00e+00 835.00
IUUC-Xma-133314 Xiphophorus maculatus 93.17 0.00e+00 808.00
IUUC-Yli-134403 Yarrowia lipolytica 37.89 9.00e-73 267.00
Created Date 25-Jun-2017

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