iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088678

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AAQR03016712

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000012229.2	ENSOGAT00000012236.2	ENSOGAP00000010943.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-65	212.3	741	779
UBD/Beta-Prp	1.00e-108	363.0	614	776

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+r+ +  k
   Q: 741  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVRSANEKK 779
           8***********777*****************9987665 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vht+ +h+++v
   Q: 614  HTDAVYHACFSQDGQRIASCGADKTLQVFKFETGEKLLEIKAHEDEVLCCAFSMDDRFIATCSVDKKVKIWNSVTGELVHTYDEHSEQV 702
           45555557777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 98   lslsfspsg..dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
           ++++f  ++    l++Gs+d+ +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd+++++
   Q: 703  TCCHFTNNShhLLLATGSSDSFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDVRSAN 776
           77777774422345667777777777777777776.777777777777777777777777777777777776543 PP

Organism

Otolemur garnettii

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QYKEALEKDI KTAYIMDHMI GDGVLTISEE EKVKNEPTQQ KRAAMLIKMI 60
LKKDNYSYIS FYNALLLEGY KDLAALLQDG IPVVSSSSDK DSGGGITTYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGATGGA CGCAAAAGCT CGGAACTGTT TGCTTCAATA TAAAGAAGCT CTGGAAAAGG 60
ACATCAAAAC AGCCTACATC ATGGATCACA TGATTGGGGA TGGAGTTTTA ACAATTTCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	90.34	0.00e+00	2302.00
IUUC-Apl-004201	Anas platyrhynchos	70.10	0.00e+00	1804.00
IUUC-Aca-004638	Anolis carolinensis	67.92	0.00e+00	1796.00
IUUC-Ani-009285	Aspergillus nidulans	25.58	2.00e-67	251.00
IUUC-Ame-011062	Astyanax mexicanus	54.91	0.00e+00	1377.00
IUUC-Bta-012865	Bos taurus	89.27	0.00e+00	2313.00
IUUC-Cja-018815	Callithrix jacchus	80.67	0.00e+00	2027.00
IUUC-Cfa-020222	Canis familiaris	85.97	0.00e+00	2173.00
IUUC-Cpo-021524	Cavia porcellus	87.83	0.00e+00	2268.00
IUUC-Csa-023861	Chlorocebus sabaeus	91.35	0.00e+00	2344.00
IUUC-Cho-024484	Choloepus hoffmanni	79.71	0.00e+00	1215.00
IUUC-Dre-028006	Danio rerio	53.89	0.00e+00	1271.00
IUUC-Dno-029591	Dasypus novemcinctus	90.87	0.00e+00	2349.00
IUUC-Dor-030237	Dipodomys ordii	75.95	0.00e+00	1088.00
IUUC-Ete-032620	Echinops telfairi	85.97	0.00e+00	1107.00
IUUC-Eca-033569	Equus caballus	90.31	0.00e+00	2323.00
IUUC-Eeu-035354	Erinaceus europaeus	66.88	0.00e+00	642.00
IUUC-Fca-036337	Felis catus	90.72	0.00e+00	2338.00
IUUC-Fal-037077	Ficedula albicollis	70.06	0.00e+00	1804.00
IUUC-Gmo-039687	Gadus morhua	50.53	0.00e+00	930.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.66	1.00e-42	169.00
IUUC-Gga-040299	Gallus gallus	68.35	0.00e+00	1804.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.96	0.00e+00	1293.00
IUUC-Ggo-045563	Gorilla gorilla	91.59	0.00e+00	2351.00
IUUC-Hsa-046771	Homo sapiens	91.11	0.00e+00	2344.00
IUUC-Lch-050200	Latimeria chalumnae	64.92	0.00e+00	1636.00
IUUC-Loc-052090	Lepisosteus oculatus	59.64	0.00e+00	1510.00
IUUC-Laf-053861	Loxodonta africana	90.39	0.00e+00	2314.00
IUUC-Mcc-055543	Macaca mulatta	91.99	0.00e+00	2357.00
IUUC-Meu-056688	Macropus eugenii	80.27	0.00e+00	2038.00
IUUC-Mga-059243	Meleagris gallopavo	69.27	0.00e+00	1828.00
IUUC-Mmr-061134	Microcebus murinus	88.21	0.00e+00	2050.00
IUUC-Mdo-062913	Monodelphis domestica	78.99	0.00e+00	2043.00
IUUC-Mmu-063811	Mus musculus	87.99	0.00e+00	2291.00
IUUC-Mpu-066780	Mustela putorius furo	90.48	0.00e+00	2308.00
IUUC-Mlu-067276	Myotis lucifugus	88.96	0.00e+00	2295.00
IUUC-Nle-069129	Nomascus leucogenys	90.95	0.00e+00	2338.00
IUUC-Opr-071007	Ochotona princeps	67.41	0.00e+00	1124.00
IUUC-Ont-071348	Oreochromis niloticus	55.56	0.00e+00	1412.00
IUUC-Oan-072717	Ornithorhynchus anatinus	80.42	0.00e+00	2102.00
IUUC-Ocu-074286	Oryctolagus cuniculus	90.22	0.00e+00	1981.00
IUUC-Ola-086895	Oryzias latipes	51.16	0.00e+00	1209.00
IUUC-Oar-089359	Ovis aries	89.11	0.00e+00	2305.00
IUUC-Ptr-091062	Pan troglodytes	91.35	0.00e+00	2347.00
IUUC-Pan-092528	Papio anubis	93.40	0.00e+00	1380.00
IUUC-Psi-093430	Pelodiscus sinensis	73.37	0.00e+00	1912.00
IUUC-Pma-094690	Petromyzon marinus	38.43	9.00e-152	530.00
IUUC-Pfo-097204	Poecilia formosa	55.28	0.00e+00	1388.00
IUUC-Pab-097690	Pongo abelii	91.51	0.00e+00	2349.00
IUUC-Pca-100778	Procavia capensis	71.86	0.00e+00	1201.00
IUUC-Pva-102870	Pteropus vampyrus	87.71	0.00e+00	2093.00
IUUC-Rno-104889	Rattus norvegicus	88.63	0.00e+00	2273.00
IUUC-Sha-107465	Sarcophilus harrisii	79.36	0.00e+00	2086.00
IUUC-Sar-113268	Sorex araneus	90.60	0.00e+00	677.00
IUUC-Ssc-115654	Sus scrofa	89.11	0.00e+00	2310.00
IUUC-Tgu-117302	Taeniopygia guttata	70.14	0.00e+00	1813.00
IUUC-Tru-118363	Takifugu rubripes	54.53	0.00e+00	1378.00
IUUC-Tsy-119007	Tarsius syrichta	87.02	0.00e+00	2221.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.37	0.00e+00	1337.00
IUUC-Tbe-127413	Tupaia belangeri	77.67	0.00e+00	1419.00
IUUC-Ttr-129213	Tursiops truncatus	83.25	0.00e+00	2109.00
IUUC-Vpa-130146	Vicugna pacos	84.95	0.00e+00	1619.00
IUUC-Xtr-132559	Xenopus tropicalis	60.78	0.00e+00	1541.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence