iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007658

UUCD1 version

UUC-ArT-01720

Ensembl Protein ID

AT3G21280.1

UniProt Accession

Q84WC6; F4IXI8; Q9FPT3; Q9LU31; UBP7_ARATH

Genbank Protein ID

AAG42752.1; BAB01721.1; AEE76487.1; AAO42031.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7

Genbank Nucleotide ID

AF302661; AB023045; CP002686; BT003992

Gene Name

UBP7; At3g21280; MXL8.15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G21280	AT3G21280.2	AT3G21280.2
AT3G21280	AT3G21280.1	AT3G21280.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-59	201.9	160	527
ULD/UDP/UBQ/UBQ_Other	4.50e-10	40.1	61	128

Active Site

Position(s)	Description	Evidence
113	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
425	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.....gyeqqDaqE 94
           Gl NlgNtCYmNS++QcL+++pel++ l +   ++ + ++ ++++  l+ + ++lf+el +++ kav+p  ++ +l+k+ ++f      + +qqDa+E
   Q: 160  GLVNLGNTCYMNSTMQCLISVPELKSELSN--YQSARTKDVDQTSHMLTVATRELFSEL-DKSVKAVAPMPFWMVLQKKYPQFAqlhngNHMQQDAEE 254
           9*****************************..4445555568999**************.9999*******************99999999******* PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLe 192
           +++++l +l+++l                       +   +++ ++ ++ lF+  l +++ c+e  ++ss++e+ ++l+++++ + +     l++ L+
   Q: 255  CWTQMLYTLSQSL-----------------------KLPSPSEDPDAVKALFGLNLLNRLHCQESSEESSETESVFSLKCHISHEVN----HLHEGLK 325
           *************.......................346788999**************************************9886....6888887 PP
   S: 193  sftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....................... 267
           +  k e le      +++  +    +k+  +++lP++L++++ Rf +++e +++ ki +kv++pleLd+   c++                       
   Q: 326  HGLKGE-LE----KTSPSLGRTAVYVKESLIDSLPRYLTVQFVRFFWKRESNQKAKILRKVDYPLELDIYDLCSEdlrkkleaprqklrdiegqklgl 418
           766665.44....47899999999***************************************************66665555555555555555555 PP
   S: 268  peekqke.......................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           +                                             + +Y+L++v+ H+G s++sGHYva+vk+e+gkW+++dD + +  + e++ + 
   Q: 419  Q-----AsakssskgddvkmtdaegssnqsgesstgdqqegasphmTGIYDLVSVLTHKGrSADSGHYVAWVKQESGKWVQYDDANTSLQRGEDIIKL 511
           0.....0555555555666666666666667777777788888999***************************************************8 PP
   S: 326  tg....staYvlfYkr 337
           +g    + aY+++Yk 
   Q: 512  SGggdwHMAYIVMYKA 527
           88************97 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           vk+ +    +++++ s +  ++K +++++ g+ppe+q++++kG +L+dd +++ +glk+g++++++ +
   Q: 61   VKWQKKVFESIEIDTSQPPFVFKAQLYDLSGVPPERQKIMVKGGLLKDDADWSTLGLKNGQKLMMMGT 128
           66666556677799999999*********************************************976 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MVIKPDPNQP GSTHPVRILA YIETKKEEEG KFFFFDIACL GFKKEINLVS LQHQTMLTVS 60
VKWQKKVFES IEIDTSQPPF VFKAQLYDLS GVPPERQKIM VKGGLLKDDA DWSTLGLKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTTTC CTTTAATTTT AGATTTATTT TTATGTCAGC AAAACGCTGC CGTATTGGGT 60
TTTAGGTCTG TTGTCTTTCT GAAGCAAGAT GGTGATCAAA CCCGACCCGA ATCAACCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00240--ubiquitin
PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G21280

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004031	Anas platyrhynchos	41.24	2.00e-109	388.00
IUUC-Aca-004361	Anolis carolinensis	40.83	2.00e-108	385.00
IUUC-Aly-006176	Arabidopsis lyrata	94.97	0.00e+00	895.00
IUUC-Acl-008258	Aspergillus clavatus	35.41	4.00e-83	301.00
IUUC-Afl-008732	Aspergillus flavus	35.17	1.00e-83	303.00
IUUC-Afu-008755	Aspergillus fumigatus	36.75	7.00e-84	304.00
IUUC-Ani-009148	Aspergillus nidulans	35.75	5.00e-84	304.00
IUUC-Ang-009878	Aspergillus niger	35.16	9.00e-80	290.00
IUUC-Aor-010239	Aspergillus oryzae	35.17	7.00e-84	303.00
IUUC-Ate-010243	Aspergillus terreus	35.91	2.00e-82	298.00
IUUC-Ame-011327	Astyanax mexicanus	30.96	1.00e-23	103.00
IUUC-Bgr-012231	Blumeria graminis	34.52	2.00e-80	293.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	42.74	3.00e-102	364.00
IUUC-Csv-026007	Ciona savignyi	36.90	7.00e-85	306.00
IUUC-Dme-032079	Drosophila melanogaster	37.30	3.00e-92	331.00
IUUC-Fal-037528	Ficedula albicollis	41.20	9.00e-108	383.00
IUUC-Fox-037805	Fusarium oxysporum	37.12	2.00e-86	312.00
IUUC-Fso-038177	Fusarium solani	37.77	1.00e-83	303.00
IUUC-Gmo-038953	Gadus morhua	42.33	5.00e-106	377.00
IUUC-Ggr-039972	Gaeumannomyces graminis	34.82	1.00e-76	280.00
IUUC-Gac-041312	Gasterosteus aculeatus	41.24	6.00e-107	380.00
IUUC-Ggo-045458	Gorilla gorilla	37.60	2.00e-85	308.00
IUUC-Hvu-047821	Hordeum vulgare	70.42	6.00e-97	345.00
IUUC-Lpe-051419	Leersia perrieri	68.28	0.00e+00	635.00
IUUC-Mpo-057415	Magnaporthe poae	36.83	4.00e-81	295.00
IUUC-Mga-060016	Meleagris gallopavo	40.64	4.00e-108	384.00
IUUC-Nfi-068393	Neosartorya fischeri	35.93	1.00e-82	299.00
IUUC-Ncr-068815	Neurospora crassa	37.66	2.00e-85	309.00
IUUC-Opr-070712	Ochotona princeps	30.82	5.00e-55	208.00
IUUC-Ont-071544	Oreochromis niloticus	40.95	5.00e-101	360.00
IUUC-Oin-080072	Oryza indica	66.05	0.00e+00	629.00
IUUC-Olo-080535	Oryza longistaminata	61.55	5.00e-165	573.00
IUUC-Ola-086998	Oryzias latipes	41.78	2.00e-105	375.00
IUUC-Psi-093458	Pelodiscus sinensis	41.24	8.00e-101	360.00
IUUC-Pno-095109	Phaeosphaeria nodorum	42.08	2.00e-70	259.00
IUUC-Pop-099221	Populus trichocarpa	76.78	0.00e+00	716.00
IUUC-Pca-100791	Procavia capensis	31.88	5.00e-57	214.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	35.99	1.00e-76	279.00
IUUC-Spo-108174	Schizosaccharomyces pombe	38.41	2.00e-81	295.00
IUUC-Sbi-114778	Sorghum bicolor	68.34	0.00e+00	645.00
IUUC-Sre-115011	Sporisorium reilianum	37.33	2.00e-64	239.00
IUUC-Tgu-117063	Taeniopygia guttata	41.00	7.00e-108	383.00
IUUC-Tru-118381	Takifugu rubripes	41.00	2.00e-102	365.00
IUUC-Tsy-119076	Tarsius syrichta	38.43	2.00e-42	166.00
IUUC-Tni-119941	Tetraodon nigroviridis	40.48	2.00e-98	352.00
IUUC-Tvi-122543	Trichoderma virens	34.55	6.00e-80	290.00
IUUC-Tbe-128030	Tupaia belangeri	37.20	1.00e-90	326.00
IUUC-Uma-129657	Ustilago maydis	32.24	8.00e-76	277.00
IUUC-Yli-134453	Yarrowia lipolytica	38.52	8.00e-86	310.00
IUUC-Zma-135669	Zea mays	53.27	4.00e-156	543.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence