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Tag Content
UUCD2 ID IUUC-Bta-013395
UUCD1 version UUC-BoT-00289
Ensembl Protein ID ENSBTAP00000030842.4
UniProt Accession E1BJS7; F2Y8T8; LIN41_BOVIN
Genbank Protein ID ADZ53892.1; ENSBTAP00000030842
Protein Name E3 ubiquitin-protein ligase TRIM71; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71
Genbank Nucleotide ID HQ826939; DAAA02053578
Gene Name TRIM71; LIN41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000022744.4 ENSBTAT00000030874.4 ENSBTAP00000030842.4
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 96.48 0.00e+00 1316.00 IUUC-Hsa-045988
E3 activity/RING/RING 92.51 0.00e+00 1273.00 IUUC-Mmu-064351
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
 E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
Protein Sequence
(Fasta)
MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG AAARRLHVLP 60
CLAFCRPCLE AHRGGAPGEP LKLRCPVCDQ KVVLAEAAGM DARPSSAFLL SNLLDAVVAT 120
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Protein Fasta Sequence


>IUUC-Bta-013395|E3,RING|Bos taurus
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Nucleotide Sequence
(Fasta)
ATGGCTTCGT TCCCTGAGAC CGACTTCCAG ATCTGCCTGC TGTGCAAGGA GATGTGCGGC 60
TCGCCGGCGC CGCTCTCCTC CAACTCGTCG GCGTCGTCGT CATCCTCGCA GACGTCCACG 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013395|E3,RING|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
SMART

SM00336--BBOX
SM00557--IG_FLMN
Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0030371--F:translation repressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0001843--P:neural tube closure
GO:0021915--P:neural tube development
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001234 Ailuropoda melanoleuca 94.75 0.00e+00 1179.00
IUUC-Apl-003905 Anas platyrhynchos 93.15 0.00e+00 1144.00
IUUC-Aca-004326 Anolis carolinensis 85.88 0.00e+00 1209.00
IUUC-Ani-009171 Aspergillus nidulans 27.27 3.40e-02 33.10
IUUC-Ame-011573 Astyanax mexicanus 70.33 0.00e+00 1186.00
IUUC-Cel-018188 Caenorhabditis elegans 35.80 3.00e-107 383.00
IUUC-Cja-019863 Callithrix jacchus 96.74 0.00e+00 1310.00
IUUC-Cfa-020285 Canis familiaris 96.00 0.00e+00 1299.00
IUUC-Cpo-021879 Cavia porcellus 92.56 0.00e+00 1471.00
IUUC-Csa-024271 Chlorocebus sabaeus 96.74 0.00e+00 1308.00
IUUC-Cho-024376 Choloepus hoffmanni 98.46 0.00e+00 1179.00
IUUC-Cin-025406 Ciona intestinalis 49.27 0.00e+00 644.00
IUUC-Cne-027010 Cryptococcus neoformans 26.00 1.70e-02 31.60
IUUC-Dre-027699 Danio rerio 77.83 0.00e+00 1125.00
IUUC-Dno-029022 Dasypus novemcinctus 97.61 0.00e+00 1174.00
IUUC-Dor-031072 Dipodomys ordii 96.18 0.00e+00 1317.00
IUUC-Dme-031997 Drosophila melanogaster 47.81 4.00e-70 259.00
IUUC-Ete-032228 Echinops telfairi 98.50 0.00e+00 822.00
IUUC-Eca-033373 Equus caballus 99.42 0.00e+00 1056.00
IUUC-Eeu-034463 Erinaceus europaeus 95.94 0.00e+00 1131.00
IUUC-Fca-036184 Felis catus 95.99 0.00e+00 1185.00
IUUC-Fal-036918 Ficedula albicollis 83.43 0.00e+00 1186.00
IUUC-Fox-038003 Fusarium oxysporum 32.20 2.00e-03 36.20
IUUC-Gmo-039415 Gadus morhua 71.90 0.00e+00 888.00
IUUC-Gga-040379 Gallus gallus 89.96 0.00e+00 1254.00
IUUC-Gac-042330 Gasterosteus aculeatus 73.15 0.00e+00 995.00
IUUC-Gma-043819 Glycine max 23.05 3.00e-12 67.80
IUUC-Ggo-045208 Gorilla gorilla 96.74 0.00e+00 1304.00
IUUC-Hsa-045988 Homo sapiens 96.89 0.00e+00 1308.00
IUUC-Itr-048371 Ictidomys tridecemlineatus 98.29 0.00e+00 1192.00
IUUC-Lch-050324 Latimeria chalumnae 84.84 0.00e+00 1195.00
IUUC-Loc-052322 Lepisosteus oculatus 81.61 0.00e+00 1176.00
IUUC-Laf-054272 Loxodonta africana 94.79 0.00e+00 1253.00
IUUC-Mcc-055125 Macaca mulatta 96.74 0.00e+00 1306.00
IUUC-Meu-055934 Macropus eugenii 84.55 0.00e+00 1143.00
IUUC-Mga-059930 Meleagris gallopavo 92.82 0.00e+00 1139.00
IUUC-Mmr-060662 Microcebus murinus 97.04 0.00e+00 1304.00
IUUC-Mdo-062918 Monodelphis domestica 90.16 0.00e+00 1286.00
IUUC-Mmu-064351 Mus musculus 93.55 0.00e+00 1296.00
IUUC-Mpu-066325 Mustela putorius furo 98.83 0.00e+00 1052.00
IUUC-Mlu-067171 Myotis lucifugus 88.26 0.00e+00 1397.00
IUUC-Nle-069692 Nomascus leucogenys 96.74 0.00e+00 1308.00
IUUC-Opr-070354 Ochotona princeps 95.55 0.00e+00 1157.00
IUUC-Ont-072125 Oreochromis niloticus 76.73 0.00e+00 1094.00
IUUC-Oan-073079 Ornithorhynchus anatinus 95.04 0.00e+00 1155.00
IUUC-Ocu-073910 Oryctolagus cuniculus 95.56 0.00e+00 1293.00
IUUC-Ola-087162 Oryzias latipes 77.43 0.00e+00 1093.00
IUUC-Oga-088523 Otolemur garnettii 88.55 0.00e+00 1198.00
IUUC-Oar-090009 Ovis aries 99.13 0.00e+00 694.00
IUUC-Ptr-091173 Pan troglodytes 96.89 0.00e+00 1311.00
IUUC-Pan-091750 Papio anubis 96.60 0.00e+00 1303.00
IUUC-Psi-093053 Pelodiscus sinensis 88.89 0.00e+00 1078.00
IUUC-Pma-094227 Petromyzon marinus 58.99 7.00e-175 607.00
IUUC-Pfo-096980 Poecilia formosa 73.75 0.00e+00 1063.00
IUUC-Pab-098189 Pongo abelii 96.59 0.00e+00 1310.00
IUUC-Pva-103126 Pteropus vampyrus 98.22 0.00e+00 1296.00
IUUC-Rno-105653 Rattus norvegicus 95.01 0.00e+00 1308.00
IUUC-Sce-106389 Saccharomyces cerevisiae 25.64 4.30e-02 32.30
IUUC-Sha-107178 Sarcophilus harrisii 94.17 0.00e+00 1151.00
IUUC-Sar-113613 Sorex araneus 85.51 0.00e+00 977.00
IUUC-Tgu-116963 Taeniopygia guttata 92.48 0.00e+00 1137.00
IUUC-Tru-117942 Takifugu rubripes 77.33 0.00e+00 1097.00
IUUC-Tsy-119075 Tarsius syrichta 89.55 0.00e+00 1058.00
IUUC-Tni-120704 Tetraodon nigroviridis 81.74 0.00e+00 1008.00
IUUC-Tre-122209 Trichoderma reesei 25.84 1.20e-02 33.50
IUUC-Tbe-128141 Tupaia belangeri 78.23 0.00e+00 812.00
IUUC-Ttr-128908 Tursiops truncatus 92.70 0.00e+00 726.00
IUUC-Xtr-132272 Xenopus tropicalis 84.40 0.00e+00 1157.00
Created Date 25-Jun-2017

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