iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-104999

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase NHLRC1; Malin; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1

Genbank Nucleotide ID

BK001524

Gene Name

Nhlrc1; Epm2b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000026286.2	ENSRNOT00000031656.2	ENSRNOP00000030625.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.59	3.00e-172	602.00	IUUC-Hsa-046346

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Protein Sequence
(Fasta)

MGEEAAGVRP ELVREAEVSL LECKVCFERF GHRQQRRPRN LPCGHVVCLA CVAALAHPRT 60
LALECPFCRR ACRACDTSDC LPVLHLLELL GSTLHASPAA LSAASCAPGA LTCYHAFGGW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAGG AGGCAGCGGG GGTGCGGCCC GAGCTGGTGC GCGAGGCGGA GGTCAGCCTG 60
CTGGAGTGCA AGGTGTGCTT CGAGAGGTTC GGCCACCGGC AGCAGCGGCG CCCGCGCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR013017--NHL_repeat_subgr
IPR015943--WD40/YVTN_repeat-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

rno:364682

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003482	Anas platyrhynchos	50.00	1.00e-57	215.00
IUUC-Aca-004781	Anolis carolinensis	54.66	3.00e-120	424.00
IUUC-Ame-011442	Astyanax mexicanus	43.84	3.00e-76	278.00
IUUC-Bta-013205	Bos taurus	82.58	1.00e-168	585.00
IUUC-Cfa-020810	Canis familiaris	83.20	1.00e-156	545.00
IUUC-Cpo-022053	Cavia porcellus	74.46	2.00e-118	418.00
IUUC-Csa-023522	Chlorocebus sabaeus	82.83	2.00e-164	572.00
IUUC-Dno-029008	Dasypus novemcinctus	78.47	1.00e-159	555.00
IUUC-Ete-032878	Echinops telfairi	80.00	1.00e-44	173.00
IUUC-Eca-034419	Equus caballus	84.22	1.00e-165	575.00
IUUC-Eeu-034990	Erinaceus europaeus	79.16	5.00e-157	547.00
IUUC-Fca-035755	Felis catus	81.75	8.00e-171	592.00
IUUC-Fal-036689	Ficedula albicollis	59.54	3.00e-42	164.00
IUUC-Fox-037671	Fusarium oxysporum	45.61	8.00e-07	47.40
IUUC-Gmo-038749	Gadus morhua	42.23	3.00e-69	255.00
IUUC-Gga-040860	Gallus gallus	55.19	1.00e-100	360.00
IUUC-Gac-041602	Gasterosteus aculeatus	41.62	7.00e-74	270.00
IUUC-Ggo-044705	Gorilla gorilla	81.06	5.00e-164	570.00
IUUC-Hsa-046346	Homo sapiens	83.59	2.00e-165	575.00
IUUC-Itr-048387	Ictidomys tridecemlineatus	83.42	1.00e-165	575.00
IUUC-Lch-049978	Latimeria chalumnae	44.97	7.00e-93	333.00
IUUC-Loc-051893	Lepisosteus oculatus	48.16	1.00e-90	326.00
IUUC-Mcc-054648	Macaca mulatta	83.08	2.00e-165	575.00
IUUC-Meu-056176	Macropus eugenii	62.34	6.00e-127	447.00
IUUC-Mmr-061462	Microcebus murinus	86.36	1.00e-165	575.00
IUUC-Mdo-062329	Monodelphis domestica	63.34	6.00e-138	483.00
IUUC-Mmu-063514	Mus musculus	95.36	0.00e+00	676.00
IUUC-Mpu-066828	Mustela putorius furo	82.82	6.00e-162	563.00
IUUC-Nle-069194	Nomascus leucogenys	83.33	7.00e-172	596.00
IUUC-Opr-070547	Ochotona princeps	79.50	3.00e-164	570.00
IUUC-Ont-071588	Oreochromis niloticus	41.48	3.00e-72	265.00
IUUC-Oan-073550	Ornithorhynchus anatinus	54.52	1.00e-101	362.00
IUUC-Ocu-074699	Oryctolagus cuniculus	79.20	1.00e-156	545.00
IUUC-Ola-087036	Oryzias latipes	41.53	3.00e-73	268.00
IUUC-Oga-088924	Otolemur garnettii	84.34	2.00e-165	574.00
IUUC-Oar-089939	Ovis aries	77.02	2.00e-106	378.00
IUUC-Ptr-091431	Pan troglodytes	83.59	2.00e-165	575.00
IUUC-Pan-092496	Papio anubis	82.83	7.00e-165	573.00
IUUC-Psi-094079	Pelodiscus sinensis	54.59	8.00e-120	423.00
IUUC-Pab-097605	Pongo abelii	83.08	8.00e-164	569.00
IUUC-Pca-100676	Procavia capensis	74.75	1.00e-161	562.00
IUUC-Pva-102804	Pteropus vampyrus	83.84	3.00e-172	597.00
IUUC-Sha-107067	Sarcophilus harrisii	63.59	3.00e-133	468.00
IUUC-Tgu-116560	Taeniopygia guttata	52.48	6.00e-40	155.00
IUUC-Tru-117560	Takifugu rubripes	39.53	1.00e-56	213.00
IUUC-Tni-120569	Tetraodon nigroviridis	41.90	1.00e-68	253.00
IUUC-Ttr-129122	Tursiops truncatus	83.84	5.00e-164	570.00
IUUC-Xtr-132226	Xenopus tropicalis	47.40	1.00e-95	343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence