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Tag Content
UUCD2 ID IUUC-Ola-086795
UUCD1 version UUC-OrL-01136
Ensembl Protein ID ENSORLP00000004146.1
UniProt Accession H2LDY1; H2LDY1_ORYLA
Genbank Protein ID ENSORLP00000004146
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID BAAF04009790
Gene Name usp16; USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSORLG00000003334.1 ENSORLT00000004147.1 ENSORLP00000004146.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.30e-78 264.8 206 832
Active Site
Position(s) Description Evidence
215 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
772 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellk 75
    +Gl+NlgNtC++N+v+Q Ls+++ lre l++ + ekln + + e+ g+l+ ++ +l++e++ skk++v+prel++
   Q: 206 KGLSNLGNTCFFNAVIQNLSQTQLLRETLNKVTGEKLNLDIKpasldllkepivvnLEQPGSLTWAMCHLLNEIQLSKKSVVTPRELFT 294
    5******************************777777666556677777778888889999**************************** PP
   S: 76 alkkeaeefsgyeqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
    +++k+a +f+g++qqD+qE+l++lld+++ e +k + n+ ++e+ + ++++++ + +e++k+ k++++++F+g+++s+i+c+
   Q: 295 QVCKKAARFKGFQQQDSQELLRYLLDGMRAEEQKqRVNTGIMEALKLTNTDKDGDglktlaKEYEKNGLPKNFVDQVFGGEMTSTIMCQ 383
    *****************************999663445555555555555555448899888999999999****************** PP
   S: 158 ecdnvssreepfldlslpvpgkeetkke............................................................. 185
    +c++vs+ +e fldlslpv ++ ++
   Q: 384 QCKTVSVVTEMFLDLSLPVVDEVKKTSAyrkknqrkgaqkssessqdgrnsppldsrnddipiagtskyqqkkakkqakkqakhqkrqq 472
    *******************9888654448999********************************************************* PP
   S: 186 ......................................................................................... 185
   
   Q: 473 klesritldsltdnteneqtnatvdaeeaetnnkeqegtsandptpdansvseqeksgeqeeeeddmadcdslaasssasnrftvlsde 561
    ***************************************************************************************** PP
   S: 186 ......................................................................................slq 188
    s+q
   Q: 562 rdsqdrvihdkmsnedqeeeddsqlvsemekvtldeafledceavdqnteseeevpdakeytvvnqdpelafstlaprtapekqvcSIQ 650
    ***************************************************************************************** PP
   S: 189 dcLesftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
    cL +ft+ e+l+ n + c +c+k+q+ a k++ +++ P vL+lhLkRf +++++ k+n++v+fpl+Ldl+
   Q: 651 TCLFQFTEVETLTLTNSLLCVTCTKQQQkkakgqgpkknvytdALKQMLVSSPPAVLTLHLKRF--QQNGYTICKVNRYVHFPLTLDLA 737
    ************************99999***********************************..77888888*************** PP
   S: 263 pfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn....................ekgkWllfdDskVtevkeeevleetgs 328
    p+c+ +++++ + + Y+L++vv HsG+++sGHY+ayvk + g+W++++D++V++v+e++v++ +
   Q: 738 PYCAAKCKTNIKedtGVLYSLYGVVEHSGTMRSGHYTAYVKVrpnhhktlsnglsteelpepSIGSWFHISDTNVQPVSESKVQS---C 823
    ****98877655666899************************999999998888877776655666*******************...* PP
   S: 329 taYvlfYkr 337
    +aY+lfY+r
   Q: 824 QAYLLFYER 832
    *******98 PP
   

Organism Oryzias latipes
Functional Description
(View)

Functional Description



     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRGKDRS SRGEDDDIEL AVPSCRHIKT AADQSLLKKL PGISDWTNCQ DCKHEDDTTL 60
QQDSEEEKEP AGIWMCLTCG HRGCGRHSEN QHAIKHYETP RSSPHCLVIS LDNWSVWCYI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ola-086795|DUB,USP|Oryzias latipes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAACAGAT GAGCCATTCT TACATTCAGC GTAGATTTCC TATATTTTAC ACACGTTTTT 60
GTATCTACTT CTTTATCTTT GCATCTTTAC TTCTACTGGC GGACCTGTAC GTAAAATAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ola-086795|DUB,USP|Oryzias latipes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 32.08 3.00e-23 104.00
IUUC-Aml-001931 Ailuropoda melanoleuca 52.59 1.00e-111 397.00
IUUC-Apl-004145 Anas platyrhynchos 53.61 2.00e-102 367.00
IUUC-Aca-004314 Anolis carolinensis 44.22 6.00e-165 574.00
IUUC-Aly-006422 Arabidopsis lyrata 29.94 6.00e-30 126.00
IUUC-Ath-006732 Arabidopsis thaliana 31.01 3.00e-32 134.00
IUUC-Ame-011659 Astyanax mexicanus 52.97 4.00e-131 462.00
IUUC-Bdi-014624 Brachypodium distachyon 32.82 2.00e-22 101.00
IUUC-Cfa-020051 Canis familiaris 51.20 2.00e-111 396.00
IUUC-Cpo-021886 Cavia porcellus 50.24 4.00e-106 379.00
IUUC-Csa-024103 Chlorocebus sabaeus 46.70 4.00e-175 608.00
IUUC-Cho-024315 Choloepus hoffmanni 49.77 6.00e-43 169.00
IUUC-Cin-025775 Ciona intestinalis 43.26 1.00e-35 141.00
IUUC-Dre-028388 Danio rerio 53.86 0.00e+00 757.00
IUUC-Dor-030443 Dipodomys ordii 46.38 2.00e-81 297.00
IUUC-Ete-032807 Echinops telfairi 44.22 8.00e-89 321.00
IUUC-Eca-033479 Equus caballus 46.76 3.00e-175 608.00
IUUC-Eeu-034835 Erinaceus europaeus 57.47 7.00e-63 235.00
IUUC-Fal-037029 Ficedula albicollis 46.03 2.00e-102 366.00
IUUC-Gmo-039480 Gadus morhua 61.01 3.00e-147 515.00
IUUC-Gga-040527 Gallus gallus 51.23 4.00e-104 372.00
IUUC-Gac-042343 Gasterosteus aculeatus 63.70 0.00e+00 938.00
IUUC-Gma-044402 Glycine max 28.50 1.00e-32 135.00
IUUC-Hvu-047146 Hordeum vulgare 32.38 5.00e-23 103.00
IUUC-Lch-050536 Latimeria chalumnae 50.24 1.00e-102 367.00
IUUC-Lpe-050703 Leersia perrieri 35.86 3.00e-23 104.00
IUUC-Loc-051814 Lepisosteus oculatus 58.41 5.00e-135 474.00
IUUC-Laf-053732 Loxodonta africana 49.88 5.00e-109 388.00
IUUC-Mcc-054661 Macaca mulatta 46.82 3.00e-175 608.00
IUUC-Meu-055967 Macropus eugenii 47.65 7.00e-92 331.00
IUUC-Mtr-057945 Medicago truncatula 30.38 5.00e-34 140.00
IUUC-Mga-059551 Meleagris gallopavo 51.20 1.00e-108 387.00
IUUC-Mdo-062220 Monodelphis domestica 52.35 2.00e-113 403.00
IUUC-Mac-064941 Musa acuminata 38.81 4.00e-31 129.00
IUUC-Mlu-067511 Myotis lucifugus 50.47 2.00e-109 390.00
IUUC-Ont-071786 Oreochromis niloticus 64.81 0.00e+00 949.00
IUUC-Oba-075094 Oryza barthii 26.69 1.00e-23 105.00
IUUC-Obr-076743 Oryza brachyantha 33.17 9.00e-24 105.00
IUUC-Ogl-077739 Oryza glaberrima 26.69 6.00e-24 106.00
IUUC-Ogu-078851 Oryza glumaepatula 26.98 3.00e-24 107.00
IUUC-Oin-079402 Oryza indica 26.98 3.00e-24 107.00
IUUC-Olo-080431 Oryza longistaminata 26.98 3.00e-24 107.00
IUUC-Ome-081580 Oryza meridionalis 27.27 3.00e-24 107.00
IUUC-Oni-082644 Oryza nivara 26.98 3.00e-24 107.00
IUUC-Opu-083452 Oryza punctata 26.87 2.00e-24 107.00
IUUC-Oru-084546 Oryza rufipogon 26.98 4.00e-24 107.00
IUUC-Osa-085858 Oryza sativa 38.10 2.00e-24 107.00
IUUC-Ptr-091670 Pan troglodytes 46.59 2.00e-174 606.00
IUUC-Pan-092293 Papio anubis 46.82 3.00e-175 608.00
IUUC-Psi-093101 Pelodiscus sinensis 50.37 9.00e-107 381.00
IUUC-Ppa-095622 Physcomitrella patens 31.25 3.00e-32 134.00
IUUC-Pfo-097202 Poecilia formosa 64.29 0.00e+00 976.00
IUUC-Pop-099588 Populus trichocarpa 27.99 2.00e-31 130.00
IUUC-Pca-101069 Procavia capensis 50.94 3.00e-60 226.00
IUUC-Ppe-101794 Prunus persica 31.59 3.00e-35 143.00
IUUC-Sha-106889 Sarcophilus harrisii 52.33 1.00e-110 394.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.61 5.00e-12 66.20
IUUC-Sit-110283 Setaria italica 39.04 7.00e-24 106.00
IUUC-Sly-111487 Solanum lycopersicum 30.58 2.00e-34 140.00
IUUC-Stu-112820 Solanum tuberosum 28.19 1.00e-35 145.00
IUUC-Sar-113530 Sorex araneus 52.35 3.00e-111 395.00
IUUC-Sbi-113785 Sorghum bicolor 37.93 3.00e-22 100.00
IUUC-Ssc-116091 Sus scrofa 51.92 2.00e-112 399.00
IUUC-Tgu-117478 Taeniopygia guttata 48.28 2.00e-99 357.00
IUUC-Tru-118640 Takifugu rubripes 60.00 0.00e+00 858.00
IUUC-Tsy-119042 Tarsius syrichta 43.92 8.00e-65 241.00
IUUC-Tni-120015 Tetraodon nigroviridis 58.75 0.00e+00 833.00
IUUC-Tca-121701 Theobroma cacao 30.15 7.00e-38 152.00
IUUC-Tae-125351 Triticum aestivum 32.86 3.00e-22 100.00
IUUC-Tur-126788 Triticum urartu 32.86 2.00e-22 100.00
IUUC-Tbe-127309 Tupaia belangeri 47.57 2.00e-67 250.00
IUUC-Ttr-128271 Tursiops truncatus 52.03 2.00e-113 403.00
IUUC-Vpa-130674 Vicugna pacos 50.11 3.00e-113 402.00
IUUC-Xtr-131869 Xenopus tropicalis 45.89 2.00e-99 357.00
IUUC-Xma-134195 Xiphophorus maculatus 64.75 0.00e+00 982.00
Created Date 25-Jun-2017

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