iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059878

UUCD1 version

UUC-MeG-00550

Ensembl Protein ID

ENSMGAP00000012823.1

UniProt Accession

G1NHY2; G1NHY2_MELGA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000012194.1	ENSMGAT00000013721.1	ENSMGAP00000012823.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.00e-56	192.4	8	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 14   dPglftl.lvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCat 101
           +P+++++ +++++gv   +++ ++ + ++e lg ++ p ++llllF+++e++e++rk+q++    +++d++i ++++f+kq+++NsC+t
   Q: 8    NPHVMNKeVLSRLGVSPGWRFVDVLGFEEEALGAVPSPACALLLLFPLTEQHENFRKQQTE----KIKDQEISSKVYFLKQTVSNSCGT 92
           8****963679************************************************98....88********************** PP
   S: 102  yAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningr 189
           ++l+++++n++dk+ ld G+ l++++++t   spe++a+ + n+++++ +hns+a++++++ + +           +fhf+++ n++g+
   Q: 93   IGLIHAVANNKDKVkLDEGSALKKFLDETADLSPEERAKRFANNKAIQEVHNSVAQEGQCRVEDN---------SVNFHFILFANVDGH 172
           ************************************************************99843.........489************ PP
   S: 190  lyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
           lyeldg+ pfP+++g ++++  lkd +k +r+f+er    e++e+rf+++a ++
   Q: 173  LYELDGRLPFPVNHGTSSDDLLLKDSAKICRQFTER----EKGEVRFSAVAFCK 222
           ************************************....99*******99876 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MKDMKCRNPH VMNKEVLSRL GVSPGWRFVD VLGFEEEALG AVPSPACALL LLFPLTEQHE 60
NFRKQQTEKI KDQEISSKVY FLKQTVSNSC GTIGLIHAVA NNKDKVKLDE GSALKKFLDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGACA TGAAATGCAG AAACCCTCAC GTCATGAACA AAGAGATAAG AAGCCCTGTA 60
TATTATCATT AACCACAGCG GACTGCTCTT GAGGAACGGA TTCAGACTAC ATGGCTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	60.56	2.00e-80	291.00
IUUC-Apl-003693	Anas platyrhynchos	91.08	3.00e-112	397.00
IUUC-Aca-004716	Anolis carolinensis	78.80	8.00e-104	369.00
IUUC-Aly-005939	Arabidopsis lyrata	42.59	1.00e-46	179.00
IUUC-Ame-011806	Astyanax mexicanus	61.11	6.00e-77	279.00
IUUC-Bta-013521	Bos taurus	60.98	9.00e-82	295.00
IUUC-Cel-018302	Caenorhabditis elegans	37.74	6.00e-32	129.00
IUUC-Cja-018752	Callithrix jacchus	73.85	3.00e-85	306.00
IUUC-Cfa-020442	Canis familiaris	73.27	5.00e-87	312.00
IUUC-Cpo-021723	Cavia porcellus	69.68	8.00e-73	265.00
IUUC-Csa-023626	Chlorocebus sabaeus	72.81	1.00e-84	305.00
IUUC-Cho-024548	Choloepus hoffmanni	75.82	2.00e-29	121.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	30.87	1.00e-24	105.00
IUUC-Dre-027854	Danio rerio	62.67	8.00e-78	282.00
IUUC-Dno-029325	Dasypus novemcinctus	72.81	3.00e-85	307.00
IUUC-Dor-030114	Dipodomys ordii	71.43	1.00e-92	332.00
IUUC-Ete-033092	Echinops telfairi	71.08	6.00e-70	256.00
IUUC-Eeu-034493	Erinaceus europaeus	69.59	2.00e-80	291.00
IUUC-Fal-036693	Ficedula albicollis	95.24	2.00e-117	414.00
IUUC-Gmo-038848	Gadus morhua	58.54	1.00e-68	252.00
IUUC-Gga-041078	Gallus gallus	98.16	4.00e-124	436.00
IUUC-Gac-042064	Gasterosteus aculeatus	61.11	2.00e-76	278.00
IUUC-Gma-043057	Glycine max	44.50	2.00e-40	158.00
IUUC-Ggo-044827	Gorilla gorilla	73.73	7.00e-86	309.00
IUUC-Hsa-045820	Homo sapiens	73.73	7.00e-86	309.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	72.35	2.00e-84	304.00
IUUC-Lch-050121	Latimeria chalumnae	65.89	5.00e-88	316.00
IUUC-Lpe-051377	Leersia perrieri	41.97	1.00e-35	142.00
IUUC-Loc-052342	Lepisosteus oculatus	64.38	3.00e-83	300.00
IUUC-Laf-053916	Loxodonta africana	71.56	3.00e-83	300.00
IUUC-Mcc-054838	Macaca mulatta	72.81	1.00e-84	305.00
IUUC-Meu-056478	Macropus eugenii	73.27	2.00e-94	337.00
IUUC-Mpo-057343	Magnaporthe poae	30.34	8.00e-16	76.30
IUUC-Mtr-057713	Medicago truncatula	43.12	1.00e-40	159.00
IUUC-Mdo-062544	Monodelphis domestica	72.35	1.00e-83	301.00
IUUC-Mmu-063300	Mus musculus	73.27	8.00e-95	338.00
IUUC-Mpu-066128	Mustela putorius furo	71.65	9.00e-72	262.00
IUUC-Mlu-067778	Myotis lucifugus	71.89	1.00e-93	335.00
IUUC-Nle-069686	Nomascus leucogenys	73.27	1.00e-85	308.00
IUUC-Opr-070535	Ochotona princeps	72.29	2.00e-71	261.00
IUUC-Ont-071510	Oreochromis niloticus	59.72	3.00e-76	276.00
IUUC-Ocu-074590	Oryctolagus cuniculus	71.89	6.00e-84	302.00
IUUC-Oba-075098	Oryza barthii	35.35	3.00e-39	154.00
IUUC-Ogu-078978	Oryza glumaepatula	33.20	5.00e-37	147.00
IUUC-Oin-079285	Oryza indica	34.88	1.00e-38	152.00
IUUC-Oni-082406	Oryza nivara	35.35	3.00e-39	154.00
IUUC-Oru-084969	Oryza rufipogon	35.35	3.00e-39	154.00
IUUC-Ola-087552	Oryzias latipes	58.37	3.00e-72	263.00
IUUC-Oga-089013	Otolemur garnettii	60.16	1.00e-80	291.00
IUUC-Oar-089861	Ovis aries	60.98	8.00e-82	295.00
IUUC-Ptr-091536	Pan troglodytes	73.27	1.00e-84	305.00
IUUC-Pan-092909	Papio anubis	72.81	1.00e-84	305.00
IUUC-Psi-093818	Pelodiscus sinensis	82.49	4.00e-106	376.00
IUUC-Pfo-097335	Poecilia formosa	61.47	3.00e-77	280.00
IUUC-Pab-098048	Pongo abelii	73.73	7.00e-86	309.00
IUUC-Pca-100818	Procavia capensis	57.67	7.00e-47	179.00
IUUC-Pva-102954	Pteropus vampyrus	73.27	8.00e-83	298.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	33.33	2.00e-30	125.00
IUUC-Rno-105966	Rattus norvegicus	73.27	8.00e-95	338.00
IUUC-Sha-107111	Sarcophilus harrisii	72.89	8.00e-72	261.00
IUUC-Stu-112526	Solanum tuberosum	44.95	6.00e-47	179.00
IUUC-Sar-113190	Sorex araneus	56.52	1.00e-26	110.00
IUUC-Ssc-115908	Sus scrofa	58.56	4.00e-70	256.00
IUUC-Tgu-117465	Taeniopygia guttata	90.52	1.00e-110	391.00
IUUC-Tru-118565	Takifugu rubripes	61.76	9.00e-74	268.00
IUUC-Tsy-119561	Tarsius syrichta	71.08	1.00e-69	255.00
IUUC-Tae-122693	Triticum aestivum	39.73	7.00e-41	160.00
IUUC-Tbe-128048	Tupaia belangeri	72.89	5.00e-72	262.00
IUUC-Ttr-128494	Tursiops truncatus	73.08	2.00e-81	294.00
IUUC-Vpa-130783	Vicugna pacos	41.70	2.00e-50	191.00
IUUC-Xtr-132286	Xenopus tropicalis	65.90	4.00e-83	300.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence