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Tag Content
iUUCD ID IUUC-Mla-058819
Ensembl Protein ID EGG10559
UniProt Accession F4RAY9; F4RAY9_MELLP
Genbank Protein ID EGG10559.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID GL883094
Gene Name PAC1; LIS1; MELLADRAFT_115481
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
MELLADRAFT_115481 EGG10559 EGG10559
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-52 172.8 354 392
UBD/Beta-Prp 1.80e-71 240.4 118 452
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++++++ f ++ ++l+s+sdD+ti++WDlrtg+++k
   Q: 354 GHDNWIRAIVFhPNgKHLLSASDDKTIRIWDLRTGRCVK 392
    8***********777**********************97 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdk 108
    h ++it+v+f+p s ++++s+d+tikvwd++tg++ +l+gh++ v +v+++ +g +lv++s+D t+k+wd s ++ c+ tl h++sv s++f+p + +
   Q: 118 HRAPITAVTFHPRFSNVVSASEDSTIKVWDYETGDFEVTLKGHTKVVCDVDYDTKGTFLVSCSSDLTLKLWDCSnNYRCIKTLYDHDHSVSSCRFMPGDTH 218
    677********************************************************************998799********************99** PP
   S: 109 lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng................. 192
    +vs+s+d+ i++w++ t c++ tl+gh+++v++v p+g+ lvs+s+D+t r+Wd++tg+ +l+g h++ v+ f ++
   Q: 219 IVSASRDQRIKLWEVATSFCVK-TLRGHSEWVRGVWPCPSGRWLVSASNDQTSRIWDVSTGETKLELRG-HEHVVEVAVFAPDLansairelagiplpsat 317
    **********************.*********************************************9.*********9999999999999999999999 PP
   S: 193 .........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav............ 272
    ++++gs+d+++++wd +g+c++ l+gh+++++ + f+pn+++l+s+s+D++iriWdlr+g ++k+l+ h + v+++a
   Q: 318 dtktksnnpIFVATGSRDKSIRIWDATSGQCLKVLIGHDNWIRAIVFHPNGKHLLSASDDKTIRIWDLRTGRCVKVLEAHDHFVTCMAWgrapagggpptt 418
    99999999999**********************************************************************99999999877777765555 PP
   S: 273 ..lsfgdnvl.................vlgsedskvniwk 293
    + ++gs d++v+iw
   Q: 419 neD------IsqsksgeavnqrvvtvmATGSVDQSVKIWT 452
    540......1444444555555555559999999999995 PP
   

Organism Melampsora laricipopulina
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MAPLSSVLSE RQKEEFHKAV LDFLFSSGFH LAFEALKSEL PSQLEFQPDP KAKWAGLLEK 60
KWTSVIRLQK KIMDLERENT LLKEELASSG STTASRRGQD DDWIPGRGGG PKHTLTGHRA 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mla-058819|E3,WD_repeat;UBD,Beta-Prp|Melampsora laricipopulina
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCAGCTTTT CATCTTATCC CAATCACTGG ACACGCCGAT CGCAACTTCA TGGCGCCCTT 60
ATCATCAGTC TTGTCAGAAC GTCAGAAGGA AGAATTGTAG GCTCCTGACC AATCTCTTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mla-058819|E3,WD_repeat;UBD,Beta-Prp|Melampsora laricipopulina
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG mlr:MELLADRAFT_115481
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 48.05 1.00e-115 407.00
IUUC-Apl-004024 Anas platyrhynchos 48.31 2.00e-119 420.00
IUUC-Aca-004564 Anolis carolinensis 47.64 6.00e-117 411.00
IUUC-Ago-007862 Ashbya gossypii 27.46 1.00e-35 142.00
IUUC-Acl-008360 Aspergillus clavatus 44.58 5.00e-109 385.00
IUUC-Afl-008502 Aspergillus flavus 44.07 7.00e-101 358.00
IUUC-Afu-008848 Aspergillus fumigatus 46.72 7.00e-117 412.00
IUUC-Ani-009173 Aspergillus nidulans 44.86 1.00e-104 371.00
IUUC-Ang-009873 Aspergillus niger 42.07 9.00e-99 351.00
IUUC-Aor-009973 Aspergillus oryzae 42.27 1.00e-97 347.00
IUUC-Ate-010523 Aspergillus terreus 43.41 6.00e-102 362.00
IUUC-Ame-010969 Astyanax mexicanus 48.09 1.00e-118 417.00
IUUC-Bgr-011972 Blumeria graminis 47.11 2.00e-115 406.00
IUUC-Bta-013106 Bos taurus 48.31 9.00e-120 421.00
IUUC-Bci-013615 Botrytis cinerea 47.56 4.00e-117 412.00
IUUC-Cel-018459 Caenorhabditis elegans 42.25 5.00e-98 348.00
IUUC-Cja-018755 Callithrix jacchus 47.19 3.00e-116 409.00
IUUC-Cfa-020749 Canis familiaris 48.31 9.00e-120 421.00
IUUC-Cpo-022371 Cavia porcellus 48.31 9.00e-120 421.00
IUUC-Csa-023524 Chlorocebus sabaeus 47.76 6.00e-99 352.00
IUUC-Cho-024764 Choloepus hoffmanni 45.36 2.00e-94 337.00
IUUC-Cin-025753 Ciona intestinalis 48.65 2.00e-109 386.00
IUUC-Csv-025817 Ciona savignyi 47.98 6.00e-111 392.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 48.18 1.00e-115 407.00
IUUC-Cne-027087 Cryptococcus neoformans 56.55 2.00e-135 473.00
IUUC-Dre-027554 Danio rerio 48.09 9.00e-119 417.00
IUUC-Dno-029050 Dasypus novemcinctus 48.31 1.00e-119 420.00
IUUC-Dor-030222 Dipodomys ordii 44.94 3.00e-106 376.00
IUUC-Dse-031164 Dothistroma septosporum 45.44 6.00e-113 398.00
IUUC-Dme-031745 Drosophila melanogaster 46.21 2.00e-106 377.00
IUUC-Ete-032508 Echinops telfairi 47.88 8.00e-83 298.00
IUUC-Eca-034288 Equus caballus 47.59 2.00e-114 403.00
IUUC-Eeu-034984 Erinaceus europaeus 44.72 3.00e-105 372.00
IUUC-Fca-036498 Felis catus 48.31 9.00e-120 421.00
IUUC-Fal-036920 Ficedula albicollis 48.31 2.00e-119 420.00
IUUC-Fox-037996 Fusarium oxysporum 47.87 4.00e-117 412.00
IUUC-Fso-038160 Fusarium solani 46.37 2.00e-111 394.00
IUUC-Gmo-038983 Gadus morhua 48.54 2.00e-120 423.00
IUUC-Ggr-040051 Gaeumannomyces graminis 44.35 2.00e-108 384.00
IUUC-Gga-040623 Gallus gallus 48.31 2.00e-119 420.00
IUUC-Gac-041613 Gasterosteus aculeatus 47.64 4.00e-118 415.00
IUUC-Ggo-045410 Gorilla gorilla 45.08 7.00e-103 365.00
IUUC-Hsa-046358 Homo sapiens 48.31 1.00e-119 420.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 48.31 9.00e-120 421.00
IUUC-Kpa-049351 Komagataella pastoris 27.22 3.00e-41 160.00
IUUC-Lch-049936 Latimeria chalumnae 48.09 4.00e-118 416.00
IUUC-Loc-052476 Lepisosteus oculatus 48.05 5.00e-115 405.00
IUUC-Lma-053170 Leptosphaeria maculans 49.14 2.00e-116 410.00
IUUC-Laf-053713 Loxodonta africana 47.51 3.00e-116 409.00
IUUC-Mcc-054628 Macaca mulatta 48.09 2.00e-119 419.00
IUUC-Meu-055927 Macropus eugenii 41.04 7.00e-65 238.00
IUUC-Mor-056962 Magnaporthe oryzae 43.92 4.00e-109 385.00
IUUC-Mpo-057583 Magnaporthe poae 44.78 3.00e-106 376.00
IUUC-Mga-059945 Meleagris gallopavo 48.31 2.00e-119 419.00
IUUC-Mvi-060403 Microbotryum violaceum 60.61 3.00e-157 546.00
IUUC-Mmr-061289 Microcebus murinus 48.05 1.00e-115 407.00
IUUC-Mdo-061912 Monodelphis domestica 48.31 3.00e-119 419.00
IUUC-Mmu-063253 Mus musculus 48.31 9.00e-120 421.00
IUUC-Mpu-066638 Mustela putorius furo 48.31 9.00e-120 421.00
IUUC-Mlu-067267 Myotis lucifugus 47.09 3.00e-116 409.00
IUUC-Nfi-068571 Neosartorya fischeri 43.22 9.00e-105 371.00
IUUC-Ncr-068895 Neurospora crassa 49.78 2.00e-116 410.00
IUUC-Nle-069087 Nomascus leucogenys 51.30 8.00e-97 344.00
IUUC-Opr-070579 Ochotona princeps 48.31 1.00e-119 420.00
IUUC-Ont-071905 Oreochromis niloticus 48.09 2.00e-119 419.00
IUUC-Oan-073072 Ornithorhynchus anatinus 48.31 9.00e-120 421.00
IUUC-Ocu-074180 Oryctolagus cuniculus 48.31 1.00e-119 420.00
IUUC-Ola-086815 Oryzias latipes 48.31 1.00e-119 421.00
IUUC-Oga-088219 Otolemur garnettii 47.54 3.00e-116 409.00
IUUC-Oar-090394 Ovis aries 48.31 9.00e-120 421.00
IUUC-Ptr-091517 Pan troglodytes 48.31 9.00e-120 421.00
IUUC-Pan-092421 Papio anubis 48.09 2.00e-119 419.00
IUUC-Psi-093370 Pelodiscus sinensis 48.31 5.00e-119 419.00
IUUC-Pma-094319 Petromyzon marinus 46.98 7.00e-100 354.00
IUUC-Pno-094815 Phaeosphaeria nodorum 49.36 3.00e-120 422.00
IUUC-Pfo-097089 Poecilia formosa 48.54 1.00e-119 421.00
IUUC-Pab-098421 Pongo abelii 48.31 9.00e-120 421.00
IUUC-Pca-100120 Procavia capensis 42.27 1.00e-69 254.00
IUUC-Pva-102960 Pteropus vampyrus 48.09 2.00e-118 416.00
IUUC-Pgr-103538 Puccinia graminis 75.82 0.00e+00 736.00
IUUC-Ptt-103990 Puccinia triticina 65.37 2.00e-88 318.00
IUUC-Pte-104261 Pyrenophora teres 49.04 2.00e-118 417.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 49.25 6.00e-119 418.00
IUUC-Rno-105123 Rattus norvegicus 48.31 9.00e-120 421.00
IUUC-Sce-106208 Saccharomyces cerevisiae 28.72 5.00e-36 143.00
IUUC-Sha-107010 Sarcophilus harrisii 48.31 2.00e-119 420.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.03 3.00e-68 250.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 48.96 7.00e-115 405.00
IUUC-Sar-113309 Sorex araneus 47.36 5.00e-113 399.00
IUUC-Sre-115003 Sporisorium reilianum 57.46 3.00e-154 536.00
IUUC-Ssc-116148 Sus scrofa 48.31 9.00e-120 421.00
IUUC-Tgu-117299 Taeniopygia guttata 48.31 3.00e-119 419.00
IUUC-Tru-117721 Takifugu rubripes 46.97 1.00e-117 414.00
IUUC-Tsy-119493 Tarsius syrichta 48.31 1.00e-118 417.00
IUUC-Tni-120355 Tetraodon nigroviridis 46.97 2.00e-116 409.00
IUUC-Tre-121977 Trichoderma reesei 41.82 7.00e-100 355.00
IUUC-Tvi-122661 Trichoderma virens 43.79 2.00e-102 364.00
IUUC-Tme-127031 Tuber melanosporum 50.00 2.00e-115 407.00
IUUC-Tbe-127492 Tupaia belangeri 45.38 2.00e-57 214.00
IUUC-Ttr-128929 Tursiops truncatus 48.31 2.00e-119 420.00
IUUC-Uma-129347 Ustilago maydis 58.04 8.00e-156 541.00
IUUC-Vda-129837 Verticillium dahliae 46.12 3.00e-110 389.00
IUUC-Vpa-130532 Vicugna pacos 44.47 6.00e-93 332.00
IUUC-Xtr-131985 Xenopus tropicalis 48.54 2.00e-119 420.00
IUUC-Xma-133314 Xiphophorus maculatus 48.54 1.00e-119 421.00
IUUC-Yli-134403 Yarrowia lipolytica 37.47 5.00e-81 292.00
Created Date 25-Jun-2017

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