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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064019
UUCD1 version UUC-MuM-01216
Ensembl Protein ID ENSMUSP00000092538.4
UniProt Accession B1AY13; Q8BLI7; UBP24_MOUSE
Genbank Protein ID BAC32195.1; CAM15750.1; CAM15750.1; CAM19818.1; CAM19818.1; CAM19819.1; ENSMUSP00000092538
Protein Name Ubiquitin carboxyl-terminal hydrolase 24; Deubiquitinating enzyme 24; Ubiquitin thioesterase 24; Ubiquitin-specific-processing protease 24
Genbank Nucleotide ID AK045043; AL954352; AL840623; AL840623; AL954352; AL840623; BC029165
Gene Name Usp24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028514.15 ENSMUST00000094933.4 ENSMUSP00000092538.4
ENSMUSG00000028514.15 ENSMUST00000165709.7 ENSMUSP00000133095.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 24286619
Classification
Family E-value Score Start End
DUB/USP 2.20e-78 265.0 1686 2038
UBD/Alpha-Helix/UBA 2.60e-05 25.3 4 41
Active Site
Position(s) Description Evidence
1695 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1967 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgy 87
           +Gl+N g+tCYmN+v Q+L++ p l e ll+     ++++  ++p+ ++  ++q+lf +l++sk +++ p++++k++k++++e+   
   Q: 1686 VGLRNGGATCYMNAVFQQLYMQPGLPESLLS-----VDDD-TDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVR 1766
           6******************************.....5444.468999**************************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           eqqDa Ef++ l+dq++e+l                          kk+  +++ +++Fqg +++q +c++c ++++ree f+ l+l
   Q: 1767 EQQDAYEFFTSLIDQMDEYL--------------------------KKMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNL 1827
           ********************..........................789999*********************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            v + +     sl+ +L++f++ e leg+n+yycekck+k+ ++k++ +k+lP vL++hL+Rf f+ e ++++k ++++ fp +L++
   Q: 1828 GVTSCQ-----SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM 1909
           ******.....9*************************************************************************** PP
   S: 262  spfcts.....peekqke.........................kkkYeLiavvvHsGslssGHYvayvkn....ekgkWllfdDskV 314
           +p+++      +     +                         +++YeL++v+vHsG+++ GHY++++k+     kgkW++f+D+ +
   Q: 1910 EPYTVAgmarqD-----SssevgengrnmdqggggsprkkvalTENYELVGVIVHSGQAHAGHYYSFIKDrrgcGKGKWYKFNDTVI 1991
           ****99566550.....34445555566666666666666666***************************55555666********* PP
   S: 315  tevk.eeevleetg.......................staYvlfYkr 337
           +e +  +e le +                        ++aY+lfY+r
   Q: 1992 EEFDlNDETLEYECfggeyrpkvydqtnpytdvrrryWNAYMLFYQR 2038
           ***844666664449******************************98 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGF.dreealqaLraannnleaAveyL 38
           e+e+ +  l  MGF d+ ++++aLr a n++++Av++L
   Q: 4    EEEQHMTTLLCMGFsDPATIRKALRLAKNDINEAVALL 41
           6788889999**************************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity).
 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity).
Protein Sequence
(Fasta)
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG 60
PSPGPGGGPR GDSGSDGSGP SRGGSTGGGG GFDPPPAYHE VVDAEKNDEN GNCSGEGIEF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064019|UBD,UBA;DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGAGGAGG AGCAGGCCAA CATGGCGGCG CGCAGGGCTG GGCCGGCCGG CCGCGCCTGA 60
GCGCCCCACC ACCCCAGCTC GGCTCGCTGC GCCCACGCGC GCACCTAACC CTGGCCCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064019|UBD,UBA;DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR033382--USP24
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:329908
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002266 Ailuropoda melanoleuca 98.10 0.00e+00 4812.00
IUUC-Apl-003203 Anas platyrhynchos 74.33 0.00e+00 3498.00
IUUC-Aca-004396 Anolis carolinensis 89.26 0.00e+00 4493.00
IUUC-Ame-011886 Astyanax mexicanus 84.24 0.00e+00 1769.00
IUUC-Bta-013381 Bos taurus 97.13 0.00e+00 4874.00
IUUC-Cel-018352 Caenorhabditis elegans 30.13 3.00e-63 238.00
IUUC-Cja-018955 Callithrix jacchus 97.63 0.00e+00 4404.00
IUUC-Cfa-020720 Canis familiaris 97.89 0.00e+00 4801.00
IUUC-Cpo-022430 Cavia porcellus 95.48 0.00e+00 3433.00
IUUC-Csa-024180 Chlorocebus sabaeus 97.87 0.00e+00 4626.00
IUUC-Cho-025074 Choloepus hoffmanni 91.74 0.00e+00 1832.00
IUUC-Dre-027696 Danio rerio 80.05 0.00e+00 4085.00
IUUC-Dno-029307 Dasypus novemcinctus 94.56 0.00e+00 4756.00
IUUC-Dor-030889 Dipodomys ordii 94.59 0.00e+00 4605.00
IUUC-Ete-032294 Echinops telfairi 92.33 0.00e+00 2317.00
IUUC-Eca-033823 Equus caballus 92.52 0.00e+00 4509.00
IUUC-Eeu-035178 Erinaceus europaeus 88.46 0.00e+00 2124.00
IUUC-Fca-035444 Felis catus 97.89 0.00e+00 4744.00
IUUC-Fal-037555 Ficedula albicollis 92.19 0.00e+00 4516.00
IUUC-Gmo-038587 Gadus morhua 80.12 0.00e+00 2494.00
IUUC-Gga-041231 Gallus gallus 91.56 0.00e+00 4616.00
IUUC-Gac-041584 Gasterosteus aculeatus 79.94 0.00e+00 2457.00
IUUC-Ggo-044502 Gorilla gorilla 96.60 0.00e+00 4858.00
IUUC-Hsa-045851 Homo sapiens 96.76 0.00e+00 4873.00
IUUC-Itr-048746 Ictidomys tridecemlineatus 97.47 0.00e+00 1573.00
IUUC-Lch-049999 Latimeria chalumnae 79.57 0.00e+00 3927.00
IUUC-Loc-051767 Lepisosteus oculatus 82.07 0.00e+00 4118.00
IUUC-Laf-054139 Loxodonta africana 96.56 0.00e+00 4867.00
IUUC-Mcc-055217 Macaca mulatta 96.83 0.00e+00 4873.00
IUUC-Meu-056659 Macropus eugenii 81.33 0.00e+00 2249.00
IUUC-Mga-059267 Meleagris gallopavo 92.36 0.00e+00 4546.00
IUUC-Mmr-060971 Microcebus murinus 95.78 0.00e+00 4819.00
IUUC-Mdo-061925 Monodelphis domestica 93.77 0.00e+00 4626.00
IUUC-Mpu-066652 Mustela putorius furo 96.91 0.00e+00 4911.00
IUUC-Mlu-067518 Myotis lucifugus 97.57 0.00e+00 4733.00
IUUC-Nle-069763 Nomascus leucogenys 97.77 0.00e+00 4749.00
IUUC-Opr-071031 Ochotona princeps 91.24 0.00e+00 4400.00
IUUC-Ont-072136 Oreochromis niloticus 78.27 0.00e+00 3992.00
IUUC-Oan-072908 Ornithorhynchus anatinus 85.13 0.00e+00 968.00
IUUC-Ocu-073880 Oryctolagus cuniculus 96.37 0.00e+00 4870.00
IUUC-Ola-086544 Oryzias latipes 77.46 0.00e+00 3853.00
IUUC-Oga-088695 Otolemur garnettii 97.44 0.00e+00 4931.00
IUUC-Oar-089401 Ovis aries 97.29 0.00e+00 4730.00
IUUC-Ptr-091657 Pan troglodytes 97.89 0.00e+00 4771.00
IUUC-Pan-092394 Papio anubis 96.87 0.00e+00 4875.00
IUUC-Psi-093813 Pelodiscus sinensis 92.41 0.00e+00 4522.00
IUUC-Pma-094698 Petromyzon marinus 53.33 4.00e-140 491.00
IUUC-Pfo-096811 Poecilia formosa 78.93 0.00e+00 3992.00
IUUC-Pab-097814 Pongo abelii 96.79 0.00e+00 4872.00
IUUC-Pca-101135 Procavia capensis 92.23 0.00e+00 2216.00
IUUC-Pva-102334 Pteropus vampyrus 92.58 0.00e+00 4619.00
IUUC-Rno-105040 Rattus norvegicus 98.70 0.00e+00 4953.00
IUUC-Sha-106658 Sarcophilus harrisii 94.44 0.00e+00 4648.00
IUUC-Sar-113153 Sorex araneus 86.62 0.00e+00 2748.00
IUUC-Ssc-115641 Sus scrofa 95.98 0.00e+00 4576.00
IUUC-Tgu-117467 Taeniopygia guttata 92.90 0.00e+00 3303.00
IUUC-Tru-118074 Takifugu rubripes 72.28 0.00e+00 3451.00
IUUC-Tsy-119165 Tarsius syrichta 93.51 0.00e+00 4507.00
IUUC-Tni-119923 Tetraodon nigroviridis 68.66 0.00e+00 3219.00
IUUC-Tbe-127910 Tupaia belangeri 88.94 0.00e+00 1816.00
IUUC-Ttr-128218 Tursiops truncatus 96.42 0.00e+00 4737.00
IUUC-Vpa-130090 Vicugna pacos 98.39 0.00e+00 1735.00
IUUC-Xtr-131911 Xenopus tropicalis 86.39 0.00e+00 1717.00
Created Date 25-Jun-2017

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