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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Hsa-046893
Ensembl Protein ID ENSP00000385523.1
UniProt Accession Q07869; B0G0X3; Q16241; Q6I9S0; Q92486; Q92689; Q9Y3N1; PPARA_HUMAN
Genbank Protein ID AAA36468.1; AAB32649.1; CAA68898.1; BAH02281.1; ACD12656.1; ABY73535.1; CAG30433.1; BAF82510.1; CAG33716.1; AAO13489.1; CAI22450.1; CAI22450.1; EAW73402.1
Protein Name Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1
Genbank Nucleotide ID L02932; S74349; Y07619; AB307690; EU650667; EU395809; CR456547; AK289821; CR457435; AY206718; AL049856; AL078611; Z94161
Gene Name PPARA; NR1C1; PPAR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000186951.16 ENST00000420804.5 ENSP00000414752.1
ENSG00000186951.16 ENST00000407236.5 ENSP00000385523.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkmiRecordsRepTarSomamiR
miRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDGRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 26556865
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Protein Sequence
(Fasta)
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC 60
PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE 120
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Protein Fasta Sequence



>IUUC-Hsa-046893|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGCCGTGGA CGCGGCGGCC CCGCGGCGGG GGCAGCGGGC GGCGGGGGCG GAGGCGGCCG 60
CTAGCGCCCT GCCCGGCGCC GCCTCCTTCG GCGTTCGCCC CACGGACCGG CAGGCGGCGG 120
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Nucleotide Fasta Sequence



>IUUC-Hsa-046893|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0035095--P:behavioral response to nicotine
GO:0044255--P:cellular lipid metabolic process
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0015908--P:fatty acid transport
GO:0007507--P:heart development
GO:0006629--P:lipid metabolic process
GO:0042157--P:lipoprotein metabolic process
GO:0032099--P:negative regulation of appetite
GO:0045776--P:negative regulation of blood pressure
GO:0010887--P:negative regulation of cholesterol storage
GO:0045820--P:negative regulation of glycolytic process
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1901215--P:negative regulation of neuron death
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0032091--P:negative regulation of protein binding
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:2000678--P:negative regulation of transcription regulatory region DNA binding
GO:0032000--P:positive regulation of fatty acid beta-oxidation
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0042060--P:wound healing

KEGG hsa:5465
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002222 Ailuropoda melanoleuca 94.04 0.00e+00 921.00
IUUC-Apl-003330 Anas platyrhynchos 88.56 0.00e+00 847.00
IUUC-Aca-004598 Anolis carolinensis 85.47 0.00e+00 817.00
IUUC-Acl-008339 Aspergillus clavatus 48.48 8.10e-02 30.40
IUUC-Ame-011508 Astyanax mexicanus 73.40 0.00e+00 696.00
IUUC-Bta-012621 Bos taurus 94.87 0.00e+00 890.00
IUUC-Cja-019688 Callithrix jacchus 97.65 0.00e+00 907.00
IUUC-Cfa-020859 Canis familiaris 94.66 0.00e+00 924.00
IUUC-Cpo-021607 Cavia porcellus 88.89 0.00e+00 835.00
IUUC-Csa-023313 Chlorocebus sabaeus 99.36 0.00e+00 920.00
IUUC-Cho-024741 Choloepus hoffmanni 83.55 0.00e+00 749.00
IUUC-Cgl-026615 Colletotrichum gloeosporioides 32.20 2.80e-01 28.10
IUUC-Dre-027446 Danio rerio 72.61 0.00e+00 682.00
IUUC-Dno-029173 Dasypus novemcinctus 92.74 0.00e+00 870.00
IUUC-Dor-030581 Dipodomys ordii 90.79 0.00e+00 815.00
IUUC-Dme-031794 Drosophila melanogaster 34.56 5.00e-56 213.00
IUUC-Ete-032330 Echinops telfairi 91.03 0.00e+00 877.00
IUUC-Eca-033712 Equus caballus 95.30 0.00e+00 881.00
IUUC-Fca-036555 Felis catus 95.32 0.00e+00 928.00
IUUC-Fal-036677 Ficedula albicollis 88.25 0.00e+00 844.00
IUUC-Gmo-039240 Gadus morhua 81.55 0.00e+00 643.00
IUUC-Gga-040473 Gallus gallus 89.10 0.00e+00 853.00
IUUC-Gac-041872 Gasterosteus aculeatus 71.88 0.00e+00 702.00
IUUC-Ggo-045226 Gorilla gorilla 100.00 0.00e+00 928.00
IUUC-Itr-048952 Ictidomys tridecemlineatus 92.95 0.00e+00 870.00
IUUC-Lch-050116 Latimeria chalumnae 79.91 0.00e+00 773.00
IUUC-Loc-052131 Lepisosteus oculatus 83.25 0.00e+00 690.00
IUUC-Laf-054323 Loxodonta africana 95.09 0.00e+00 890.00
IUUC-Mcc-054841 Macaca mulatta 99.57 0.00e+00 921.00
IUUC-Meu-056833 Macropus eugenii 83.12 0.00e+00 755.00
IUUC-Mtr-058471 Medicago truncatula 29.82 2.10e-01 30.00
IUUC-Mga-059995 Meleagris gallopavo 80.30 0.00e+00 754.00
IUUC-Mdo-061954 Monodelphis domestica 88.39 0.00e+00 782.00
IUUC-Mmu-064295 Mus musculus 92.31 0.00e+00 840.00
IUUC-Mpu-066216 Mustela putorius furo 95.09 0.00e+00 926.00
IUUC-Nle-069970 Nomascus leucogenys 99.79 0.00e+00 925.00
IUUC-Ont-071594 Oreochromis niloticus 72.94 0.00e+00 697.00
IUUC-Oan-073501 Ornithorhynchus anatinus 91.67 0.00e+00 769.00
IUUC-Ocu-074634 Oryctolagus cuniculus 85.88 0.00e+00 842.00
IUUC-Oni-082926 Oryza nivara 29.41 1.40e-02 30.80
IUUC-Ola-086585 Oryzias latipes 79.37 0.00e+00 635.00
IUUC-Oga-088738 Otolemur garnettii 97.22 0.00e+00 897.00
IUUC-Oar-090453 Ovis aries 94.44 0.00e+00 887.00
IUUC-Ptr-091518 Pan troglodytes 99.79 0.00e+00 921.00
IUUC-Pan-092006 Papio anubis 99.79 0.00e+00 921.00
IUUC-Psi-093352 Pelodiscus sinensis 86.86 0.00e+00 840.00
IUUC-Pfo-096060 Poecilia formosa 71.67 0.00e+00 684.00
IUUC-Pab-098602 Pongo abelii 93.25 0.00e+00 826.00
IUUC-Pva-102175 Pteropus vampyrus 89.53 0.00e+00 863.00
IUUC-Rno-105283 Rattus norvegicus 92.09 0.00e+00 842.00
IUUC-Sce-106436 Saccharomyces cerevisiae 29.03 9.00e-03 32.00
IUUC-Sha-106560 Sarcophilus harrisii 92.52 0.00e+00 871.00
IUUC-Smo-109075 Selaginella moellendorffii 30.00 1.40e-01 29.60
IUUC-Ssc-115266 Sus scrofa 94.44 0.00e+00 929.00
IUUC-Tgu-116778 Taeniopygia guttata 88.25 0.00e+00 844.00
IUUC-Tru-118436 Takifugu rubripes 71.67 0.00e+00 691.00
IUUC-Tsy-119642 Tarsius syrichta 83.55 0.00e+00 750.00
IUUC-Tni-119859 Tetraodon nigroviridis 71.67 0.00e+00 687.00
IUUC-Tvi-122624 Trichoderma virens 30.91 9.90e-02 29.60
IUUC-Tbe-127464 Tupaia belangeri 93.59 0.00e+00 911.00
IUUC-Ttr-129307 Tursiops truncatus 91.04 0.00e+00 838.00
Created Date 25-Jun-2017

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