iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117973

UUCD1 version

UUC-TaR-00742

Ensembl Protein ID

ENSTRUP00000044091.1

UniProt Accession

H2V4F7; H2V4F7_TAKRU

Protein Name

Uncharacterized protein

Gene Name

cul4a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017207.1	ENSTRUT00000044235.1	ENSTRUP00000044087.1
ENSTRUG00000017207.1	ENSTRUT00000044236.1	ENSTRUP00000044088.1
ENSTRUG00000017207.1	ENSTRUT00000044237.1	ENSTRUP00000044089.1
ENSTRUG00000017207.1	ENSTRUT00000044238.1	ENSTRUP00000044090.1
ENSTRUG00000017207.1	ENSTRUT00000044239.1	ENSTRUP00000044091.1
ENSTRUG00000017207.1	ENSTRUT00000044240.1	ENSTRUP00000044092.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.70e-184	615.1	45	720

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkvee...sedeqlLktynreWe..kfreqlkvl 83
           klr+av +i++++s+++++eely+av+nlc++kv+  lYk+l++v+e+++ +q+++ +e      ++ +L   n+       +++  ++
   Q: 45   KLRDAVGAIQNSTSIQYNLEELYQAVENLCSYKVSPTLYKQLRQVCEDHVqAQIHQFREYpffCFGQPVLPEENESMLagPLQTNKIMI 133
           5899**********************************************9999998886222467889987777654115789999** PP
   S: 84   rkifayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.......... 160
           r+if++ldrtyv +++ + ++++ +l+l+r +iv+d  ++kr ++ +l+ ie eR+ge++dr+ll+++  +l++L++ +          
   Q: 134  RSIFLFLDRTYVLQNSLLPSIWDTGLELFRIHIVSDsaVQKRAVDGILEQIELERNGETIDRSLLRSLLGMLSDLQSARprqiflrdal 222
           **************9999*********************************************************99889********* PP
   S: 161  .............laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhl 236
                        l++y++sFE++fl++t ++y+ae ++++ e++v eYl++v  rl+ee++r+  yl++st+++L+ +vek+l+ +h+
   Q: 223  servtvglsrwllLKVYRDSFEERFLTETDRLYAAEGQRLMLERDVPEYLHHVVRRLEEENDRILSYLDQSTQKPLIGCVEKQLLGEHM 311
           ***************************************************************************************** PP
   S: 237  esll.aelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndak 324
           +++l ++l +ll++++  +l+++y+L+s+v+ gl +ll+ ++ +ik  g +++  +ek+kd   +V++ll++k+k++++ + +F  ++ 
   Q: 312  TAILqKGLRNLLDENRVTELTLLYQLFSKVKGGLPTLLQFWRDYIKAFGGEIVCTPEKDKD---MVQDLLDFKDKMDNVAQCCFARNEG 397
           **9989*******************************************************...************************* PP
   S: 325  Flkaldkafetfvnknsvlka.........akspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRL 404
           F++++++afetf+nk+s + a            + l A+y+D++Lr+++k++teeele++ldk++++f++i++kdvFe++Ykk+LakRL
   Q: 398  FINTMKEAFETFINKRSNKPAeligecafnLVIASLPAKYVDSKLRAGNKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRL 486
           ****************7777799*9998876667788**************************************************** PP
   S: 405  lsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaele. 492
           l+gksas +aE+s+++kLk+ecga+ftskLe+Mf+d+++S+d+++qFk+ ++n+++ +++el+v++L++g+Wp ++ +e v+LP+e++ 
   Q: 487  LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQSDPTNIELTVNILTMGYWPSYTPME-VHLPTEVRt 574
           ***************************************************************************9998.9***98763 PP
   S: 493  ..........ktiekfeefYlekhsgRkLqWqhtlgraelkael........................kkgkyelqVstfQmavLLafn 547
                     k++e f+ fYl khsgRkLqWq tlg+a lkae+                         +gk+elqVs fQ++vLL+fn
   Q: 575  qesmcifqmvKLQEVFKLFYLGKHSGRKLQWQPTLGHAVLKAEFkevtdiniaprgknqtcnyshyfvLQGKKELQVSLFQTLVLLMFN 663
           333333333368999*****************************99******9999999999999988888****************** PP
   S: 548  nsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           + e++svee++ at++++ eLrrtlqsL+++k++vl+k+p +k++e++d f +N+ef
   Q: 664  EGEEFSVEEIQTATGIEDGELRRTLQSLACGKARVLNKNPRGKDVEDGDRFNFNNEF 720
           ********************************************************9 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

HSRNGMARTS AVASTKTGAS KKIVIKNFKD RPKLSENYTE DTWLKLRDAV GAIQNSTSIQ 60
YNLEELYQAV ENLCSYKVSP TLYKQLRQVC EDHVQAQIHQ FREYPFFCFG QPVLPEENES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCAAACT TTAAACCCCT TCTAAAAGGG ACAACATGTA TTAAGTCTAG CAGCTCATCA 60
CCTCCGTCGA GGAGGTTATG TATAGCCAGC GTTTGTCTGT ATTAATAATA TAAATCAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0035118--P:embryonic pectoral fin morphogenesis
GO:0007507--P:heart development
GO:0071600--P:otic vesicle morphogenesis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010809	Astyanax mexicanus	81.43	0.00e+00	1252.00
IUUC-Gac-042280	Gasterosteus aculeatus	83.45	0.00e+00	1143.00
IUUC-Mla-058936	Melampsora laricipopulina	36.68	8.00e-110	391.00
IUUC-Ont-071562	Oreochromis niloticus	84.00	0.00e+00	1330.00
IUUC-Ola-087101	Oryzias latipes	83.50	0.00e+00	1320.00
IUUC-Pfo-097037	Poecilia formosa	83.15	0.00e+00	1313.00
IUUC-Tni-119798	Tetraodon nigroviridis	85.23	0.00e+00	1347.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence