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Tag Content
UUCD2 ID IUUC-Mlu-067786
UUCD1 version UUC-MyL-01194
Ensembl Protein ID ENSMLUP00000012492.2
UniProt Accession G1PNH4; G1PNH4_MYOLU
Genbank Protein ID ENSMLUP00000012492
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAPE02008731
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000013714.2 ENSMLUT00000013725.2 ENSMLUP00000012492.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.60e-56 190.8 311 848
UBD/Alpha-Helix/UBA 2.70e-14 52.8 718 755
Active Site
Position(s) Description Evidence
320 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
811 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 311  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 398
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 399  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 458
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+ + 
   Q: 459  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAVI 544
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
            + ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 545  STSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskvwpheeasscndsavas 632
           *********************997.*******************999889999999999999999999999999888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 633  hffapdasdidessvmqlaemgfpleacrkavhmeepgrwsemewlsslmqnsdfaepltmpgyggaasagasvfgatgldnqppeetv 721
           88888888887777777777777777777777777777777777777777666666666666666666666666666666666665555 PP
   S: 268  ..................peekqke.................................................kkkYeLiavvvHsG. 288
                                   +                                                 +  YeL+a ++H+G 
   Q: 722  siitsmgfhrnqaiqalrA-----TnsnleraldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGt 805
           5555555555555555550.....05555556666666666666666666666666677888888888888888*************** PP
   S: 289  slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           s+ sGHYv+++k+ +g+W+ ++D++V ++  e+  +   + +Y++fY+r
   Q: 806  STMSGHYVCHIKK-EGRWVIYNDHRVCAS--ERPPK---DLGYMYFYRR 848
           *************.9***********999..78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ +  +++MGF r++a+qaLra+n nle+A+++++++
   Q: 718  EETVSIITSMGFHRNQAIQALRATNSNLERALDWIFSH 755
           7889999*****************************97 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
MPTIRVPRSG DRVYKTECAF SYDSPNSEGG LYVCMNTFLA FGREHVERHF RKTGQSVYMH 60
LKRHVREKVK GASGGALPKR RNSKIFLDLD TDDDLNSDDY EYEDEAKLVI FPDHYEIALP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-067786|DUB,USP;UBD,UBA|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCGGCTCG GTGCGCGCCG CGGCCATGCA GCGCCGGGGC GCCCTGTTCG GCGTGCCGGG 60
CGGCAGCGGC AGCAGGAAGA TGGCTGCAGG GGACATCGGC GAGCTGCTGG TGCCCCACAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-067786|DUB,USP;UBD,UBA|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 90.95 0.00e+00 1467.00
IUUC-Apl-003712 Anas platyrhynchos 77.74 0.00e+00 1282.00
IUUC-Aca-004634 Anolis carolinensis 79.88 0.00e+00 1307.00
IUUC-Ame-011470 Astyanax mexicanus 70.55 0.00e+00 1199.00
IUUC-Bta-013349 Bos taurus 90.96 0.00e+00 1506.00
IUUC-Cja-019021 Callithrix jacchus 89.55 0.00e+00 1447.00
IUUC-Cfa-020614 Canis familiaris 91.30 0.00e+00 1471.00
IUUC-Cpo-022484 Cavia porcellus 90.05 0.00e+00 1416.00
IUUC-Csa-024078 Chlorocebus sabaeus 90.73 0.00e+00 1464.00
IUUC-Cho-024522 Choloepus hoffmanni 76.54 0.00e+00 1109.00
IUUC-Cme-027335 Cyanidioschyzon merolae 24.91 5.00e-52 199.00
IUUC-Dre-027651 Danio rerio 71.16 0.00e+00 1264.00
IUUC-Dno-028975 Dasypus novemcinctus 90.28 0.00e+00 1460.00
IUUC-Dor-030130 Dipodomys ordii 77.13 0.00e+00 870.00
IUUC-Ete-032251 Echinops telfairi 75.21 0.00e+00 1191.00
IUUC-Eca-033568 Equus caballus 91.41 0.00e+00 1426.00
IUUC-Eeu-034612 Erinaceus europaeus 85.94 0.00e+00 972.00
IUUC-Fca-036280 Felis catus 91.28 0.00e+00 1422.00
IUUC-Fal-036610 Ficedula albicollis 80.27 0.00e+00 1261.00
IUUC-Gmo-038906 Gadus morhua 68.87 0.00e+00 1168.00
IUUC-Gga-041215 Gallus gallus 79.91 0.00e+00 1323.00
IUUC-Gac-042441 Gasterosteus aculeatus 68.49 0.00e+00 1186.00
IUUC-Ggo-044446 Gorilla gorilla 90.49 0.00e+00 1464.00
IUUC-Hsa-046546 Homo sapiens 90.73 0.00e+00 1464.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 87.62 0.00e+00 1373.00
IUUC-Lch-050425 Latimeria chalumnae 74.42 0.00e+00 1268.00
IUUC-Loc-052072 Lepisosteus oculatus 73.60 0.00e+00 1213.00
IUUC-Laf-053909 Loxodonta africana 88.54 0.00e+00 1446.00
IUUC-Mcc-054686 Macaca mulatta 90.73 0.00e+00 1464.00
IUUC-Meu-056361 Macropus eugenii 85.19 0.00e+00 1046.00
IUUC-Mga-059972 Meleagris gallopavo 77.00 0.00e+00 1246.00
IUUC-Mmr-060916 Microcebus murinus 89.91 0.00e+00 1456.00
IUUC-Mdo-062302 Monodelphis domestica 84.09 0.00e+00 1404.00
IUUC-Mmu-063639 Mus musculus 88.50 0.00e+00 1491.00
IUUC-Mac-065634 Musa acuminata 38.56 9.00e-169 587.00
IUUC-Mpu-066533 Mustela putorius furo 91.30 0.00e+00 1472.00
IUUC-Nle-069997 Nomascus leucogenys 92.05 0.00e+00 1396.00
IUUC-Ont-071859 Oreochromis niloticus 70.15 0.00e+00 1209.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.28 2.00e-128 451.00
IUUC-Ocu-074265 Oryctolagus cuniculus 90.49 0.00e+00 1464.00
IUUC-Ola-087344 Oryzias latipes 69.18 0.00e+00 1212.00
IUUC-Oga-088734 Otolemur garnettii 90.38 0.00e+00 1456.00
IUUC-Oar-089636 Ovis aries 92.50 0.00e+00 1487.00
IUUC-Ptr-090982 Pan troglodytes 90.85 0.00e+00 1468.00
IUUC-Pan-091991 Papio anubis 90.85 0.00e+00 1466.00
IUUC-Psi-093509 Pelodiscus sinensis 82.57 0.00e+00 1352.00
IUUC-Pfo-096029 Poecilia formosa 70.18 0.00e+00 1237.00
IUUC-Pab-098672 Pongo abelii 86.50 0.00e+00 1368.00
IUUC-Pca-100860 Procavia capensis 82.81 0.00e+00 860.00
IUUC-Pva-102545 Pteropus vampyrus 83.22 0.00e+00 1332.00
IUUC-Rno-105210 Rattus norvegicus 87.68 0.00e+00 1469.00
IUUC-Sha-106805 Sarcophilus harrisii 87.25 0.00e+00 736.00
IUUC-Sar-113733 Sorex araneus 94.88 0.00e+00 768.00
IUUC-Tgu-116591 Taeniopygia guttata 81.29 0.00e+00 1332.00
IUUC-Tru-118627 Takifugu rubripes 68.50 0.00e+00 1214.00
IUUC-Tsy-119278 Tarsius syrichta 81.86 0.00e+00 1258.00
IUUC-Tni-120804 Tetraodon nigroviridis 70.16 0.00e+00 1234.00
IUUC-Ttr-128295 Tursiops truncatus 83.94 0.00e+00 1318.00
IUUC-Vpa-130170 Vicugna pacos 79.69 0.00e+00 1244.00
IUUC-Xtr-132809 Xenopus tropicalis 72.89 0.00e+00 1227.00
Created Date 25-Jun-2017

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