iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045600

UUCD1 version

UUC-GoG-01086

Ensembl Protein ID

ENSGGOP00000003483.2

UniProt Accession

G3QLW2; G3QLW2_GORGO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000003539.2	ENSGGOT00000003563.2	ENSGGOP00000003483.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.60e-107	358.2	147	691

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 147  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 230
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk.............eknkpkeeeeeedkselsde................................... 129
           qqD+qEfl++l+dql+eelk+             +++++++e++e d+s ++de                                   
   Q: 231  QQDTQEFLRCLMDQLHEELKEpvvatvalteardSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrgggslqaetellipdea 319
           *******************99886666665555555555555555555555555*********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 320  graisekermkdrkfswgqqrtnseqvdedadvdtamaalddqpaeaqppsprssspcrtpepdndahlrsssrpcspvhhheghakls 408
           ***************************************************************************************** PP
   S: 130  ..........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....... 185
                                     ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+       
   Q: 409  ssppraspvrmapsyvlkkaqvlsagSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqn 497
           *****************************************************************************99888******* PP
   S: 186  ..........................................slqdcLesftkeeele..genkyycekckkkqeaekklklkklPevL 230
                                                     +l+dcL++f++++el+  g+n+y+ce+ckk+++ +k +k+ +lPe+L
   Q: 498  vpakpgacgdgyaaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKalGDNMYSCERCKKLRNGVKYCKVLRLPEIL 586
           *********************************************************9667**************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefp...le.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskV 314
           ++hLkRf  ++e + + kin++v+fp   le Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++V
   Q: 587  CIHLKRF--RHELMYSFKINSHVSFPlegLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYV 671
           *******..9999*************8886679**********999..9**************************78999********* PP
   S: 315  tevkeeevleetgstaYvlfYkr 337
           tev+e+ v++   +++YvlfY++
   Q: 672  TEVHETVVQN---AEGYVLFYRK 691
           **********...********98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

ARMGDSRDLC PHLDSIGEVT KEDLLLKSKG TCQSCGVTGP NLWACLQVAC PYVGCGESFA 60
DHSTIHAQAK KHNLTVNLTT FRLWCYACEK EVFLEQRLAA PLLGSSSKFS EQDSPPPSHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCAGGATGG GGGACTCCAG GGACCTTTGC CCTCACCTTG ACTCCATAGG AGAGGTGACC 60
AAAGAGGACT TGCTGCTCAA ATCTAAGGTA AAGGGTCAGA CCTTACGGGG CCAGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	92.52	0.00e+00	1660.00
IUUC-Apl-003351	Anas platyrhynchos	86.18	0.00e+00	1558.00
IUUC-Aca-005077	Anolis carolinensis	76.12	0.00e+00	1108.00
IUUC-Ame-011777	Astyanax mexicanus	75.46	0.00e+00	1335.00
IUUC-Bta-013063	Bos taurus	93.26	0.00e+00	1659.00
IUUC-Cja-019868	Callithrix jacchus	96.52	0.00e+00	1760.00
IUUC-Cfa-020761	Canis familiaris	93.37	0.00e+00	1678.00
IUUC-Cpo-022267	Cavia porcellus	86.23	0.00e+00	1552.00
IUUC-Csa-024251	Chlorocebus sabaeus	98.04	0.00e+00	1782.00
IUUC-Cho-024483	Choloepus hoffmanni	93.95	1.00e-121	430.00
IUUC-Csv-025889	Ciona savignyi	43.71	2.00e-35	141.00
IUUC-Dre-028061	Danio rerio	74.09	0.00e+00	1210.00
IUUC-Dno-029423	Dasypus novemcinctus	94.78	0.00e+00	1706.00
IUUC-Dor-030877	Dipodomys ordii	90.91	0.00e+00	1085.00
IUUC-Dme-031837	Drosophila melanogaster	48.92	6.00e-135	475.00
IUUC-Ete-032802	Echinops telfairi	81.43	5.00e-136	478.00
IUUC-Eca-034283	Equus caballus	92.83	0.00e+00	1656.00
IUUC-Eeu-034620	Erinaceus europaeus	89.99	0.00e+00	1178.00
IUUC-Fca-036357	Felis catus	94.02	0.00e+00	1673.00
IUUC-Fal-037411	Ficedula albicollis	86.13	0.00e+00	1557.00
IUUC-Gmo-038944	Gadus morhua	60.13	0.00e+00	1049.00
IUUC-Gga-041101	Gallus gallus	85.56	0.00e+00	1540.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.67	0.00e+00	1315.00
IUUC-Hsa-045825	Homo sapiens	98.91	0.00e+00	1767.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	82.13	0.00e+00	1407.00
IUUC-Lch-050002	Latimeria chalumnae	76.43	0.00e+00	1329.00
IUUC-Loc-052574	Lepisosteus oculatus	77.25	0.00e+00	1403.00
IUUC-Laf-054428	Loxodonta africana	92.84	0.00e+00	1655.00
IUUC-Mcc-055736	Macaca mulatta	97.82	0.00e+00	1778.00
IUUC-Meu-056645	Macropus eugenii	52.92	0.00e+00	886.00
IUUC-Mga-059781	Meleagris gallopavo	85.13	0.00e+00	1541.00
IUUC-Mmr-061241	Microcebus murinus	57.60	0.00e+00	1054.00
IUUC-Mdo-063048	Monodelphis domestica	86.89	0.00e+00	1529.00
IUUC-Mmu-064079	Mus musculus	91.75	0.00e+00	1634.00
IUUC-Mpu-066616	Mustela putorius furo	92.19	0.00e+00	1701.00
IUUC-Mlu-067294	Myotis lucifugus	92.17	0.00e+00	1602.00
IUUC-Nle-070015	Nomascus leucogenys	98.26	0.00e+00	1719.00
IUUC-Opr-070328	Ochotona princeps	92.73	0.00e+00	1665.00
IUUC-Ont-071464	Oreochromis niloticus	74.11	0.00e+00	1305.00
IUUC-Oan-073259	Ornithorhynchus anatinus	79.10	0.00e+00	1312.00
IUUC-Ocu-074630	Oryctolagus cuniculus	90.54	0.00e+00	1592.00
IUUC-Ola-087240	Oryzias latipes	74.87	0.00e+00	1286.00
IUUC-Oga-088761	Otolemur garnettii	93.80	0.00e+00	1712.00
IUUC-Oar-089490	Ovis aries	87.92	0.00e+00	1491.00
IUUC-Ptr-091662	Pan troglodytes	98.91	0.00e+00	1766.00
IUUC-Pan-092199	Papio anubis	98.26	0.00e+00	1790.00
IUUC-Psi-093726	Pelodiscus sinensis	86.75	0.00e+00	1556.00
IUUC-Pma-094389	Petromyzon marinus	62.79	9.00e-100	356.00
IUUC-Pfo-097415	Poecilia formosa	60.33	0.00e+00	1082.00
IUUC-Pab-098632	Pongo abelii	98.48	0.00e+00	1753.00
IUUC-Pca-100614	Procavia capensis	85.71	0.00e+00	1283.00
IUUC-Pva-102922	Pteropus vampyrus	92.11	0.00e+00	983.00
IUUC-Rno-105215	Rattus norvegicus	91.41	0.00e+00	1633.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.82	3.00e-24	107.00
IUUC-Sha-106601	Sarcophilus harrisii	86.13	0.00e+00	1519.00
IUUC-Sar-113665	Sorex araneus	58.69	0.00e+00	1093.00
IUUC-Ssc-115533	Sus scrofa	91.70	0.00e+00	1640.00
IUUC-Tgu-117364	Taeniopygia guttata	86.71	0.00e+00	1544.00
IUUC-Tru-117770	Takifugu rubripes	72.36	0.00e+00	1280.00
IUUC-Tsy-119598	Tarsius syrichta	51.43	0.00e+00	875.00
IUUC-Tni-120001	Tetraodon nigroviridis	72.83	0.00e+00	1257.00
IUUC-Ttr-128732	Tursiops truncatus	93.80	0.00e+00	1672.00
IUUC-Vpa-130598	Vicugna pacos	57.17	0.00e+00	1065.00
IUUC-Xtr-132157	Xenopus tropicalis	76.14	0.00e+00	1353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence